Liver regeneration
Open accessAbstract
Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other.
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AREG and EREG activate EGFR signaling in hepatocytes, driving their proliferation, especially in liver zones 1 and 2.
“These ligands activate epidermal growth factor receptor (EGFR) signaling in hepatocytes driving their proliferation, especially in liver zones 1 and 2[4,20].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [20]
The “Ligands of EGFR” and “Mitogenic Signals Associated With Initiation of Liver Regeneration” sections identify amphiregulin (AREG) as an EGFR ligand and describe EGFR ligands as direct mitogens for hepatocytes in culture. They do not establish the claim for epiregulin (EREG) or show that these ligands drive proliferation especially in liver zones 1 and 2. The passages provide no page numbers. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIL-6 plays a central role in restoring normal hepatic function following liver injury.
“Additionally, IL-6 plays a central role in restoring normal hepatic function following liver injury [1], [2].”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [1]
The Interleukin 6 (IL6) section describes IL-6 as contributing to early liver regeneration and supporting the acute-phase response and biliary-tree integrity. It also says regeneration can be essentially normal in IL-6-deficient mice and cautions that IL-6 is not the initiator of regeneration. Thus, the source supports a contributory role, but not the claimed central role in restoring normal hepatic function after injury. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe ability of the gut microbiome to remodel and persist in the face of insults such as antibiotic use is probably only matched in the host by the regenerative capacity of the liver.
“The ability of the gut microbiome to remodel and persist in the face of insults such as antibiotic use is probably only matched in the host by the regenerative capacity of the liver (Michalopoulos, 2007) (Fig. 1, A and B).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Michalopoulos, 2007
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Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963 · see citing works
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280 · see citing works
Liver immunology and its role in inflammation and homeostasis
Robinson, M. W., Harmon, C., & O’Farrelly, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.3 · Cited by 1,151 · see citing works
Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998 · see citing works
Self-citationNotch Signaling in Development, Tissue Homeostasis, and Disease
Siebel, C., & Lendahl, U. (2017) · Physiological Reviews · doi:10.1152/physrev.00005.2017 · Cited by 968 · see citing works
TGF-β in progression of liver disease
Dooley, S., & ten Dijke, P. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1246-y · Cited by 718 · see citing works
Liver Regeneration after Partial Hepatectomy
Michalopoulos, G. K. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090675 · Cited by 713 · see citing works
Self-citationMechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions
Yan, M., Huo, Y., Yin, S., & Hu, H. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.019 · Cited by 687 · see citing works
The Hippo signaling pathway in stem cell biology and cancer
Mo, J., Park, H. W., & Guan, K. (2014) · EMBO Reports · doi:10.15252/embr.201438638 · Cited by 682 · see citing works
Fernández, M., Semela, D., Bruix, J., Colle, I. O., Pinzani, M., & Bosch, J. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.011 · Cited by 598 · see citing works
Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
Miyajima, A., Tanaka, M., & Itoh, T. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.010 · Cited by 570 · see citing works
Stem Cells and Liver Regeneration
Duncan, A. W., Dorrell, C., & Grompe, M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.044 · Cited by 547 · see citing works
Cancer stem cells in the development of liver cancer
Yamashita, T., & Wang, X. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66024 · Cited by 526 · see citing works
The role of long noncoding RNAs in hepatocellular carcinoma
Huang, Z., Zhou, J., Peng, Y., He, W., & Huang, C. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01188-4 · Cited by 512 · see citing works
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.026 · Cited by 486 · see citing works
Cancer across the tree of life: cooperation and cheating in multicellularity
Aktipis, C. A., Boddy, A. M., Jansen, G., Hibner, U., Hochberg, M. E., Maley, C. C., & Wilkinson, G. S. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0219 · Cited by 466 · see citing works
Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration
Miyaoka, Y., Ebato, K., Kato, H., Arakawa, S., Shimizu, S., & Miyajima, A. (2012) · Current Biology · doi:10.1016/j.cub.2012.05.016 · Cited by 461 · see citing works
Hepatostat: Liver regeneration and normal liver tissue maintenance
Michalopoulos, G. K. (2017) · Hepatology · doi:10.1002/hep.28988 · Cited by 444 · see citing works
Self-citationFate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
Malato, Y., Naqvi, S., Schürmann, N., Ng, R., Wang, B., Zape, J., Kay, M. A., Grimm, D., & Willenbring, H. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59261 · Cited by 434 · see citing works
Liver regeneration — mechanisms and models to clinical application
Forbes, S. J., & Newsome, P. N. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.97 · Cited by 413 · see citing works
Bioprinting: From Tissue and Organ Development to in Vitro Models
Mota, C., Camarero‐Espinosa, S., Baker, M., Wieringa, P., & Moroni, L. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00789 · Cited by 308 · see citing works
Omenetti, A., Porrello, A., Jung, Y., Yang, L., Popov, Y. V., Choi, S. S., Witek, R. P., Alpini, G. D., Venter, J., VanDongen, H. M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35875 · Cited by 342 · see citing works
Hepatic stellate cells in physiology and pathology
Kamm, D. R., & McCommis, K. S. (2022) · The Journal of Physiology · doi:10.1113/jp281061 · Cited by 351 · see citing works
Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture
Peng, W. C., Logan, C. Y., Fish, M., Anbarchian, T., Aguisanda, F., Álvarez-Varela, A., Wu, P., Jin, Y., Zhu, J., Li, B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.11.012 · Cited by 331 · see citing works
The three R’s of lung health and disease: repair, remodeling, and regeneration
Beers, M. F., & Morrisey, E. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45961 · Cited by 321 · see citing works
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat
Hu, J., Srivastava, K., Wieland, M. J., Runge, A., Mogler, C., Besemfelder, E., Terhardt, D., Vogel, M. J., Cao, L., Korn, C., et al. (2014) · Science · doi:10.1126/science.1244880 · Cited by 320 · see citing works
Human liver stem cell‐derived microvesicles accelerate hepatic regeneration in hepatectomized rats
Herrera, M. B., Fonsato, V., Gatti, S., Deregibus, M. C., Sordi, A., Cantarella, D., Calogero, R., Bussolati, B., Tetta, C., & Camussi, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00860.x · Cited by 309 · see citing works
Liver regeneration and inflammation: from fundamental science to clinical applications
Campana, L., Esser, H., Huch, M., & Forbes, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00373-7 · Cited by 307 · see citing works
Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion
Williams, M. J., Clouston, A. D., & Forbes, S. J. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.034 · Cited by 301 · see citing works
Print Me An Organ! Why We Are Not There Yet
Ng, W. L., Chua, C. K., & Shen, Y. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101145 · Cited by 292 · see citing works
Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes
Deng, X., Zhang, X., Li, W., Feng, R.-X., Li, L., Yi, G.-R., Zhang, X.-N., Yin, C., Yu, H.-Y., Zhang, J.-P., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.05.022 · Cited by 289 · see citing works
Pluripotent stem cell-derived hepatocyte-like cells
Schwartz, R. E., Fleming, H. E., Khetani, S. R., & Bhatia, S. N. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.01.003 · Cited by 281 · see citing works
Regulation of liver regeneration by growth factors and cytokines
Böhm, F., Köhler, U. A., Speicher, T., & Werner, S. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000085 · Cited by 275 · see citing works
Design Considerations for Hydrogel Wound Dressings: Strategic and Molecular Advances
Veld, R. C. O. ‘., Walboomers, X. F., Jansen, J. A., & Wagener, F. A. D. T. G. (2020) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2019.0281 · Cited by 276 · see citing works
Liver zonation: Novel aspects of its regulation and its impact on homeostasis
Gebhardt, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8491 · Cited by 275 · see citing works
Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liverPreprint
Benhamouche, S., Curto, M., Saotome, I., Gladden, A. B., Liu, C.-H., Giovannini, M., & McClatchey, A. I. (2010) · Genes & Development · doi:10.1101/gad.1938710 · Cited by 269 · see citing works
Tissue repair and regeneration with endogenous stem cells
Xia, H., Li, X., Gao, W.-W., Fu, X., Fang, R. H., Zhang, L.-F., & Zhang, K. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0027-6 · Cited by 235 · see citing works
Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan1230 · Cited by 261 · see citing works
“INTRODUCTION After moderate liver injury or resection, the liver regenerates efficiently through hepatocyte proliferation (1, 2).”
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad
Nejak-Bowen, K. N., & Monga, S. P. S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.12.010 · Cited by 260 · see citing works
Identification of small molecules for human hepatocyte expansion and iPS differentiation
Shan, J., Schwartz, R. E., Ross, N. T., Logan, D. J., Thomas, D., Duncan, S. A., North, T. E., Goessling, W., Carpenter, A. E., & Bhatia, S. N. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1270 · Cited by 254 · see citing works
Cellular Homeostasis and Repair in the Mammalian Liver
Stanger, B. Z. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170255 · Cited by 248 · see citing works
Mao, S. A., Glorioso, J. M., & Nyberg, S. L. (2014) · Translational research · doi:10.1016/j.trsl.2014.01.005 · Cited by 245 · see citing works
Principles of Liver Regeneration and Growth Homeostasis
Michalopoulos, G. K. (2012) · Comprehensive physiology · doi:10.1002/cphy.c120014 · Cited by 267 · see citing works
Self-citationRecent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
Dzobo, K., Motaung, K. S., & Adesida, A. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184628 · Cited by 236 · see citing works
Model systems for regeneration: zebrafish
Marques, I. J., Lupi, E., & Mercader, N. (2019) · Development · doi:10.1242/dev.167692 · Cited by 240 · see citing works
Liver sinusoidal endothelial cells and liver regeneration
DeLeve, L. D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66025 · Cited by 233 · see citing works
Acetaminophen-induced Liver Injury: from Animal Models to Humans
Jaeschke, H., Xie, Y., & McGill, M. R. (2014) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2014.00014 · Cited by 226 · see citing works
Mechano-modulatory synthetic niches for liver organoid derivation
Sorrentino, G., Rezakhani, S., Yildiz, E., Nuciforo, S., Heim, M. H., Lutolf, M. P., & Schoonjans, K. (2020) · Nature Communications · doi:10.1038/s41467-020-17161-0 · Cited by 224 · see citing works
Timchenko, N. A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.01.005 · Cited by 220 · see citing works
The balancing act of the liver: tissue regeneration versus fibrosis
Cordero-Espinoza, L., & Huch, M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93562 · Cited by 220 · see citing works
Human Gut Microbiota and Drug Metabolism
Pant, A., Maiti, T. K., Mahajan, D., & Das, B. (2022) · Microbial Ecology · doi:10.1007/s00248-022-02081-x · Cited by 228 · see citing works
Evidence for Novel Hepaciviruses in Rodents
Drexler, J. F., Corman, V. M., Müller, M. A., Lukashev, A. N., Gmyl, A. P., Coutard, B., Adam, A. C., Ritz, D., Leijten, L. M. E., van Riel, D. A. J., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003438 · Cited by 209 · see citing works
Micrornas Control Hepatocyte Proliferation During Liver Regeneration
Song, G., Sharma, A. D., Roll, G. R., Ng, R., Lee, A. Y., Blelloch, R. H., Frandsen, N. M., & Willenbring, H. (2010) · Hepatology · doi:10.1002/hep.23547 · Cited by 207 · see citing works
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
Antony, A. N., Paillard, M., Moffat, C., Juskeviciute, E., Correnti, J., Bolon, B., Rubin, E., Csordás, G., Seifert, E. L., Hoek, J. B., et al. (2016) · Nature Communications · doi:10.1038/ncomms10955 · Cited by 206 · see citing works
Role of the Nrf2-ARE Pathway in Liver Diseases
Shin, S. M., Yang, J. H., & Ki, S. H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/763257 · Cited by 205 · see citing works
Bhushan, B., Walesky, C. M., Manley, M. W., Gallagher, T., Borude, P. C., Edwards, G., Monga, S. P., & Apte, U. M. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.07.019 · Cited by 204 · see citing works
Goetzman, E. S., & Prochownik, E. V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00129 · Cited by 199 · see citing works
Schlegel, A. A., Lesurtel, M., Melloul, E., Limani, P., Tschuor, C., Graf, R., Humar, B., & Clavien, P. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000949 · Cited by 194 · see citing works
Xiao, J., Liong, E. C., Ching, Y. P., Chang, R. C., So, K., Fung, M., & Tipoe, G. L. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.11.033 · Cited by 189 · see citing works
Prediction, prevention and management of postresection liver failure
Hammond, J. S., Guha, I. N., Beckingham, I. J., & Lobo, D. N. (2011) · British journal of surgery · doi:10.1002/bjs.7630 · Cited by 187 · see citing works
Mirshafiei, M., Rashedi, H., Yazdian, F. A., Rahdar, A., & Baino, F. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112853 · Cited by 182 · see citing works
Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury
Apte, U. M., Singh, S., Zeng, G., Cieply, B. W., Virji, M. A., Wu, T., & Monga, S. P. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080976 · Cited by 179 · see citing works
Liver Regeneration after Acetaminophen Hepatotoxicity
Bhushan, B., & Apte, U. (2019) · The American Journal of Pathology · doi:10.1016/j.ajpath.2018.12.006 · Cited by 179 · see citing works
Extracellular Matrix Remodeling in Chronic Liver Disease
Ortiz, C., Schierwagen, R., Schaefer, L., Klein, S., Trepat, X., & Trebicka, J. (2021) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-021-00030-3 · Cited by 183 · see citing works
The Transcription Factor FOXM1 (Forkhead box M1)
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 174 · see citing works
The EGFR signalling system in the liver: from hepatoprotection to hepatocarcinogenesis
Berasain, C., & Avila, M. A. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0907-x · Cited by 175 · see citing works
Apte, U. M., Gkretsi, V., Bowen, W. C., Mars, W. M., Luo, J., Donthamsetty, S., Orr, A., Monga, S. P., Wu, C., & Michalopoulos, G. K. (2009) · Hepatology · doi:10.1002/hep.23059 · Cited by 173 · see citing works
Self-citationMir-33 regulates cell proliferation and cell cycle progression
Cirera-Salinas, D., Pauta, M., Allen, R. M., Salerno, A., Ramírez, C., Chamorro-Jorganes, A., Wanschel, A., Lasunción, M. A., Morales-Ruiz, M., Suárez, Y., et al. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19421 · Cited by 177 · see citing works
Molecular Biology of Liver Cancer Stem Cells
Oishi, N., Yamashita, T., & Kaneko, S. (2014) · Liver Cancer · doi:10.1159/000343863 · Cited by 169 · see citing works
Cell Plasticity in Liver Regeneration
Li, W., Li, L., & Hui, L. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.01.007 · Cited by 167 · see citing works
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease
Stevens, K. R., Scull, M. A., Ramanan, V., Fortin, C. L., Chaturvedi, R. R., Knouse, K. A., Xiao, J., Fung, C., Mirabella, T., Chen, A. X., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah5505 · Cited by 165 · see citing works
Ng, R., Song, G., Roll, G. R., Frandsen, N. M., & Willenbring, H. (2012) · Journal of Clinical Investigation · doi:10.1172/jci46039 · Cited by 164 · see citing works
Epimorphic regeneration approach to tissue replacement in adult mammals
Agrawal, V., Johnson, S. A., Reing, J. E., Zhang, L., Tottey, S., Wang, G., Hirschi, K. K., Braunhut, S. J., Gudas, L. J., & Badylak, S. F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905851106 · Cited by 160 · see citing works
Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma
Majumdar, A., Curley, S. A., Wu, X., Brown, P. H., Hwang, J. P., Shetty, K., Yao, Z., He, A. R., Li, S., Katz, L. H., et al. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.114 · Cited by 161 · see citing works
ECM formation and degradation during fibrosis, repair, and regeneration
Mayorca‐Guiliani, A. E., Leeming, D. J., Henriksen, K., Mortensen, J. H., Nielsen, S. H., Anstee, Q. M., Sanyal, A. J., Karsdal, M. A., & Schuppan, D. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00063-4 · Cited by 172 · see citing works
Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration
Grijalva, J., Huizenga, M. N., Mueller, K. A., Rodriguez, S., Brazzo, J. A., Camargo, F. D., Sadri‐Vakili, G., & Vakili, K. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00077.2014 · Cited by 159 · see citing works
The bright side of fibroblasts: molecular signature and regenerative cues in major organs
Gomes, R. N., Manuel, F., & Nascimento, D. S. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00153-z · Cited by 180 · see citing works
Rizvi, F., Everton, E., Smith, A. R., Liu, H., Osota, E., Beattie, M. B., Tam, Y. K., Pardi, N., Weissman, D., & Gouon–Evans, V. (2021) · Nature Communications · doi:10.1038/s41467-021-20903-3 · Cited by 154 · see citing works
New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
Giraldez, M. D., Carneros, D., Garbers, C., Rose-John, S., & Bustos, M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00473-x · Cited by 156 · see citing works
To divide or not to divide: revisiting liver regeneration
Miyaoka, Y., & Miyajima, A. (2013) · Cell Division · doi:10.1186/1747-1028-8-8 · Cited by 156 · see citing works
Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma
Sangineto, M., Villani, R., Cavallone, F., Romano, A. D., Loizzi, D., & Serviddio, G. (2020) · Cancers · doi:10.3390/cancers12061419 · Cited by 152 · see citing works
Elucidating the Metabolic Regulation of Liver Regeneration
Huang, J., & Rudnick, D. A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.04.034 · Cited by 149 · see citing works
Liver regeneration by stem/progenitor cells
Itoh, T., & Miyajima, A. (2013) · Hepatology · doi:10.1002/hep.26753 · Cited by 151 · see citing works
Damania, A., Jaiman, D., Teotia, A. K., & Kumar, A. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0752-6 · Cited by 150 · see citing works
A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration
Wuestefeld, T., Pesic, M., Rudalska, R., Dauch, D., Longerich, T., Kang, T.-W., Yevsa, T., Heinzmann, F., Hoenicke, L., Hohmeyer, A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.026 · Cited by 149 · see citing works
Kordes, C., & Häussinger, D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66027 · Cited by 148 · see citing works
Preserved liver-specific functions of hepatocytes in 3D co-culture with endothelial cell sheets
Kim, K.-S., Ohashi, K., Utoh, R., Kano, K., & Okano, T. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.084 · Cited by 149 · see citing works
Lu, X., Cao, X., Zhu, Y., Wu, Z., Zhuang, X., Shao, M., Xu, Q., Zhou, Y., Ji, H., Lu, Q.-R., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0428-x · Cited by 146 · see citing works
Implications of microbiota and bile acid in liver injury and regeneration
Liu, H., Keane, R., Sheng, L., & Wan, Y. Y. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.001 · Cited by 145 · see citing works
Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma
Kowalik, M. A., Columbano, A., & Perra, A. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00087 · Cited by 145 · see citing works
Woo, D., Kim, S., Lim, H., Heo, J., Park, H. S., Kang, G., Kim, S. E., You, H., Hoeppner, D. J., Kim, Y., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.030 · Cited by 144 · see citing works
The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner
Wang, J., Clauson, C. L., Robbins, P. D., Niedernhofer, L. J., & Wang, Y. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00828.x · Cited by 142 · see citing works
Allard, M.-A., Adam, R., Bucur, P.-O., Termos, S., Cunha, A. S., Bismuth, H., Castaing, D., & Vibert, E. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182a64b38 · Cited by 142 · see citing works
Epithelial Plasticity during Liver Injury and Regeneration
Gadd, V. L., Aleksieva, N., & Forbes, S. J. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.08.016 · Cited by 142 · see citing works
Bipotent transitional liver progenitor cells contribute to liver regeneration
Pu, W., Zhu, H., Zhang, M., Pikiolek, M., Ercan, C., Li, J., Huang, X., Han, X., Zhang, Z., Lv, Z., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01335-9 · Cited by 138 · see citing works
Harnessing macrophage plasticity for tissue regeneration
Smith, T. D., Nagalla, R. R., Chen, E. Y., & Liu, W. F. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.012 · Cited by 138 · see citing works
A Mouse Model of Accelerated Liver Aging Caused by a Defect in DNA Repair
Gregg, S. Q., Gutiérrez, V., Robinson, A. R., Woodell, T. B., Nakao, A., Ross, M. A., Michalopoulos, G. K., Rigatti, L. H., Rothermel, C. E., Kamileri, I., et al. (2011) · Hepatology · doi:10.1002/hep.24713 · Cited by 136 · see citing works
Self-citationThe Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice
Wilkinson, P. D., Delgado, E. R., Alencastro, F., Leek, M. P., Roy, N., Weirich, M. P., Stahl, E. C., Otero, P. A., Chen, M. I., Brown, W. K., et al. (2019) · Hepatology · doi:10.1002/hep.30286 · Cited by 135 · see citing works
Advances in liver regeneration
Michalopoulos, G. K. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.934358 · Cited by 134 · see citing works
Self-citation
- Authors
- Michalopoulos, G. K.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Michalopoulos, George K.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2007-06-08
- Volume
- 213
- Issue
- 2
- Pages
- 286-300
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC2701258
- OpenAlex
- W4210995852
- Cited by
- 1,384
- References
- 225
- Citations by year
- 2026: 32 · 2025: 60 · 2024: 78 · 2023: 58 · 2022: 74 · 2021: 81 · 2020: 81 · 2019: 82 · 2018: 88 · 2017: 77 · 2016: 89 · 2015: 90 · 2014: 84 · 2013: 84 · 2012: 72
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ca103958-06a1, UL1TR000005, CA 103958)
- National Cancer Institute (R01CA035373, CA035373, R01-CA103958, CA103958)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, partial hepatectomy, hepatocytes, growth factors, cytokines, extracellular matrix remodeling, signaling pathways, liver homeostasis
- MeSH terms
- Animals, Epithelial Cells, Hemodynamics, Hepatectomy, Humans, Liver, Liver Regeneration, Mitosis, Stem Cells, Signal Transduction, Interleukin-6, Hepatocytes, Transforming Growth Factor beta1
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