The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Natural Selection Favors a Newly Derived timeless Allele in Drosophila melanogaster
Abstract
Circadian and other natural clock-like endogenous rhythms may have evolved to anticipate regular temporal changes in the environment. We report that a mutation in the circadian clock gene timeless in Drosophila melanogaster has arisen and spread by natural selection relatively recently in Europe. We found that, when introduced into different genetic backgrounds, natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light and temperature. The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions.
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“For example, Drosophila melanogaster that is native to Europe harbors a polymorphism in “timeless,” a key gene in the light response of the circadian system, that follows a latitudinal cline in allele frequency (Sandrelli et al. 2007; Tauber et al. 2007).”
From Archaic Introgression Shaped Human Circadian Traits (2023) · cites this paper as Tauber et al. 2007
Citations
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Items 301–308 of 308
Post-transcriptional control of the timeless mRNA in the Drosophila circadian clock
Cottineau, T. (2024) · theses.fr (ABES) · doi:10.70675/2b67e2c8z4b28z4a4ez91a8z386221aad15d
Miao, H., & Kim, W. J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106778
Major changes in gene expression between strains of diapausing and non-diapause spruce budworm
van der Burg, K. R. L., Gauthier, J., Roe, A. D., Cusson, M., Boyle, B., Lévesque, R. C., & Marshall, K. E. (2026) · PLoS ONE · doi:10.1371/journal.pone.0349357
“Gene expression and genetic mapping studies regularly point towards circadian clock genes as major factors in diapause evolution [5,8,15,61].”
Brady, D. J., & Sandrelli, F. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1953101
“Studies in Drosophila , where diapause occurs at the adult reproductive stage, support a contribution of natural variation in clock genes to photoperiodic diapause (Sandrelli et al., 2007b; Tauber et al., 2007; Yamada and Yamamoto, 2011).”
Yair, M., Fishman, B., Aslan, M., & Tauber, E. (2026) · Heredity · doi:10.1038/s41437-026-00886-x
Deppisch, P., Colizzi, F. S., & Helfrich‐Förster, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.29.754759
“The long L-TIM isoform is less light-sensitive than S-TIM and leads to an earlier onset of reproductive dormancy, which is favorable at high latitudes (Sandrelli et al., 2007; Tauber et al., 2007; Abrieux et al., 2020; Lamaze et al., 2022).”
Genetic analyses of circadian and seasonal phenotypes in Drosophila
Collins, L. (2014) · Leicester Research Archive (University of Leicester)
Molecular Genetic Analysis of a Seasonal Character in D. melanogaster Natural Populations
Zonato, V. (2013) · Figshare
Metadata
- Authors
- Tauber, E., Zordan, M., Sandrelli, F., Pegoraro, M., Osterwalder, N., Breda, C., Daga, A., Selmin, A., Monger, K., Benna, C., Rosato, E., Kyriacou, C. P., & Costa, R.
- Affiliations
- University of Padua (IT)
- Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.
- Corresponding author
- Tauber, Eran
- Zordan, Mauro
- Sandrelli, Federica
- Daga, Andrea
- Kyriacou, Charalambos P.
- ORCID
- Venue
- Science
- Published
- 2007-06-29
- Volume
- 316
- Issue
- 5833
- Pages
- 1895-1898
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142166311
- Cited by
- 308
- References
- 23
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 8 · 2023: 17 · 2022: 28 · 2021: 11 · 2020: 18 · 2019: 11 · 2018: 15 · 2017: 12 · 2016: 17 · 2015: 11 · 2014: 15 · 2013: 18 · 2012: 17
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Natural Environment Research Council (NE/D012058/1)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Keywords
- timeless gene, circadian clock, natural selection, diapause, life-history traits, seasonal adaptation, Drosophila melanogaster
- MeSH terms
- Alleles, Amino Acid Sequence, Animals, Base Sequence, Circadian Rhythm, Drosophila melanogaster, Europe, Female, Geography, Haplotypes, Molecular Sequence Data, Mutation, Phylogeny, Polymorphism, Genetic, Reproduction, Seasons, Selection, Genetic, Temperature, Transformation, Genetic, Photoperiod, Evolution, Molecular, Protein Isoforms, Drosophila Proteins
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