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Cited by 174

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Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment

Jacobs, Gerald H., Williams, Gary A., Cahill, Hugh, Nathans, Jeremy·2007·Science
DOI 10.1126/science.1138838
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Abstract

Changes in the genes encoding sensory receptor proteins are an essential step in the evolution of new sensory capacities. In primates, trichromatic color vision evolved after changes in X chromosome–linked photopigment genes. To model this process, we studied knock-in mice that expressed a human long-wavelength–sensitive (L) cone photopigment in the form of an X-linked polymorphism. Behavioral tests demonstrated that heterozygous females, whose retinas contained both native mouse pigments and human L pigment, showed enhanced long-wavelength sensitivity and acquired a new capacity for chromatic discrimination. An inherent plasticity in the mammalian visual system thus permits the emergence of a new dimension of sensory experience based solely on gene-driven changes in receptor organization.

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Research works printed but not linked: 27

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Metadata

Authors
Jacobs, G. H., Williams, G. A., Cahill, H., & Nathans, J.
Affiliations
Neuroscience Research Institute and Department of Psychology, University of California, Santa Barbara, CA 93106, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2007-03-23
Volume
315
Issue
5819
Pages
1723-1725
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1138838
Cited by
174
References
0
Language
en

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CoChat. (2026). Citation check: Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment. https://app.cochat.ai/papers/10.1126/science.1138838
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Jacobs, G. H., Williams, G. A., Cahill, H., & Nathans, J. (2007). Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment. Science. https://doi.org/10.1126/science.1138838