The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Synchrony Dynamics During Initiation, Failure, and Rescue of the Segmentation Clock
Open accessAbstract
The “segmentation clock” is thought to coordinate sequential segmentation of the body axis in vertebrate embryos. This clock comprises a multicellular genetic network of synchronized oscillators, coupled by intercellular Delta-Notch signaling. How this synchrony is established and how its loss determines the position of segmentation defects in Delta and Notch mutants are unknown. We analyzed the clock's synchrony dynamics by varying strength and timing of Notch coupling in zebra-fish embryos with techniques for quantitative perturbation of gene function. We developed a physical theory based on coupled phase oscillators explaining the observed onset and rescue of segmentation defects, the clock's robustness against developmental noise, and a critical point beyond which synchrony decays. We conclude that synchrony among these genetic oscillators can be established by simultaneous initiation and self-organization and that the segmentation defect position is determined by the difference between coupling strength and noise.
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Cites
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The Onset of Collective Behavior in Social Amoebae
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Species-specific segmentation clock periods are due to differential biochemical reaction speeds
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Metadata
- Authors
- Riedel-Kruse, I. H., Müller, C., & Oates, A. C.
- Venue
- Science
- Published
- 2007-09-28
- Volume
- 317
- Issue
- 5846
- Pages
- 1911-1915
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983149044
- Cited by
- 268
- References
- 27
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Riedel-Kruse, I. H., Müller, C., & Oates, A. C. (2007). Synchrony Dynamics During Initiation, Failure, and Rescue of the Segmentation Clock. Science. https://doi.org/10.1126/science.1142538
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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