Cited by 878Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

Seeman, P., Lee, T.·1975·Science

DOI 10.1126/science.1145194

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Abstract

Neuroleptic (antipsychotic) drugs inhibited the electrically stimulated release of [3 H]dopamine from rat striatal slices. The concentrations for 50 percent inhibition (ranging from 11.5 nanomolar for spiroperidol to 800 nanomolar for thioridazine) correlated closely with the average daily dosages of 25 neuroleptic drugs used clinically for schizophrenia. The correlation includes butyrophenones, phenothiazines, reserpine, pimozide, clozapine, and (+)-butaclamol. Clinically inactive isomers [trans-thiothixene,trans-flupenthixol, and (-)-butaclamol] required 20 to 1000 times higher concentrations than the active isomers to inhibit release. Compared to the inhibition of [3 H]dopamine release, much higher neuroleptic concentrations were needed to inhibit the electrically stimulated release of other neurotransmitters—[3 H]acetylcholine, [3 H]GABA (γ-aminobutyric acid). The neuroleptic drugs may block the presynaptic coupling between impulse and neurosecretion.

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The Membrane Actions of Anesthetics and Tranquilizers
Seeman, P. M. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06931-5 · Cited by 2,241
Self-citation
Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain
Carlsson, A., & Lindqvist, M. (1963) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1963.tb01730.x · Cited by 2,156
DOPAMINERGIC NEURONS: EFFECT OF ANTIPSYCHOTIC DRUGS AND AMPHETAMINE ON SINGLE CELL ACTIVITY
Bunney, B. S., Walters, J. R., Roth, R. H., & Aghajanian, G. K. (1973) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29539-8 · Cited by 1,283
Receptor activity and turnover of dopamine and noradrenaline after neuroleptics
Andén, N., Butcher, S. G., CORRODI, H., Fuxé, K., & Ungerstedt, U. (1970) · European Journal of Pharmacology · doi:10.1016/0014-2999(70)90006-3 · Cited by 1,026
Drugs, Neurotransmitters, and Schizophrenia
Snyder, S. H., Banerjee, S. P., Yamamura, H. I., & Greenberg, D. A. (1974) · Science · doi:10.1126/science.184.4143.1243 · Cited by 834
The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs.
Jm, V. R. (1966) · PubMed · Cited by 508
Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs
Clement‐Cormier, Y. C., Kebabian, J. W., Petzold, G. L., & Greengard, P. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.4.1113 · Cited by 452
Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity
Kehr, W., Carlsson, A., Lindqvist, M., Magnusson, T., & Atack, C. (1972) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1972.tb09104.x · Cited by 417
IS IT POSSIBLE TO PREDICT THE CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA?I. "NEUROLEPTIC ACTIVITY SPECTRA" FOR RATS.
Janssen, P. A., Cj, N., & Schellekens, K. H. L. (1965) · PubMed · Cited by 348
Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?
Matthysse, S. (1973) · PubMed · Cited by 338

Flagged first, then by citations

Show all 35 references

Research works printed but not linked: 9

Aghajanian, G. K., Frontiers in Neurology and Neuroscience Research: 4 (1974).
FARNEBO, L. O., ACTA PHYSIOLOGICA SCANDINAVICA 371: 19 (1971).
FARNEBO, L. O., ACTA PHYSIOLOGICA SCANDINAVICA 371: 35 (1971).
Munkvad, I., The Neuroleptics. Modern Problems in Pharmacopsychiatrv 5: 44 (1970).
RITCHIE, J.M., ON ACTIVE STRUCTURE OF LOCAL ANESTHETICS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 133: 241 (1961).
SEEMAN, P, FEDERATION PROCEEDINGS 33: 246 (1974).
SOTELO, C, ULTRASTRUCTURAL IDENTIFICATION OF NIGRAL DOPAMINERGIC CELLS IN RAT, JOURNAL DE PHARMACOLOGIE 5: 55 (1974).
STAWARZ, R.J., SIGNIFICANCE OF INCREASE OF HOMOVANILLIC-ACID (HVA) CAUSED BY ANTIPSYCHOTICS IN CORPUS STRIATUM AND LIMBIC FOREBRAIN, FEDERATION PROCEEDINGS 33: 246 (1974).
ZIVKOVIC, B, SPECIFIC ACTIVATION OF STRIATAL TYROSINE-HYDROXYLASE (TH) BY NEUROLEPTICS, FEDERATION PROCEEDINGS 33: 536 (1974).

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Binding of apomorphine to neural membranes
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Relevance of GABA in the Nigrostriatal System
Racagni, G., Cattabeni, F., & Groppetti, A. (1979) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-5199-1_28 · Cited by 4
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Sykes, D. A., Lochray, J. M., Comfort, H. M. F., Jain, P., & Charlton, S. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.14.468520 · Cited by 4
“The common mechanism of antipsychotic drug action is postsynaptic dopamine antagonism (Creese et al., 1975; Seeman and Lee, 1975; Seeman et al., 1976), which forms the basis of the original ‘dopamine hypothesis’ of schizophrenia and the subsequent ‘modified dopamine hypothesis’ which argued for the regional specificit…”
Background
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“…model of psychosis revolves around the “dopamine hypothesis” which posits the central role of mesolimbic hyperdopaminergia, and hinges originally upon the dose-related efficacy of dopamine-blocking agents known as antipsychotics (Creese et al, 1976; Seeman & Lee, 1975; Seeman et al., 1976).”
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Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action
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Die moderne Psychopharmakologie aus wissenschaftshistorischer Sicht
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“The dopamine hypothesis of schizophrenia is based on the observation that dopamine agonists such as amphetamine and cocaine cause psychotic-like symptoms and, moreover, traditional antipsychotic drugs act by blocking dopamine receptors in the brain (Seeman and Lee 1975).”
Background
Dopamine and Serotonin Crosstalk Within the Dopaminergic and Serotonergic Systems
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“antipsychotic drugs were found to be potent inhibitors of the DA D2 class of receptors (Seeman and Lee 1975; Creese et al. 1976; Seeman 1980).”
Background
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Evidence from brain imaging studies for dopaminergic alterations in schizophrenia
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Background
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Prolactin-releasing effect of zetidoline, a new neuroleptic agent, in the rat
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Neuroleptic Drugs. Chemical versus Biochemical Classification
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Action of Antipsychotics on LSD-induced Neurochemical and Behavioural Effects in Rats
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Synthesis and radiolabelling of [123I]‐4‐iodo‐N‐(4‐(4‐(2‐methoxyphenyl)‐piperazin‐1‐yl)butyl)‐benzamide, a potential dopamine D3 antagonist for SPECT studies
Staelens, L., Dumont, F., Vos, F. D., Oltenfreiter, R., Vandecapelle, M., Dierckx, R. A., & Slegers, G. (2003) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.683 · Cited by 3
Neuroleptics
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Clozapine Administration Modifies Neurotensin Effect on Synaptosomal Membrane Na+, K+ -ATPase Activity
Ordieres, M. G. L., & Arnaiz, G. R. D. L. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0018-5 · Cited by 2
Applications of Clinical Dopamine Imaging
Lindsey, K. P., & Gatley, S. J. (2007) · PET Clinics · doi:10.1016/j.cpet.2007.09.005 · Cited by 2
Schizophrenia: Presentation, Affect and Cognition, Pathophysiology and Etiology
MacDonald, A. W., & Demro, C. (2023) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197542521.003.0014 · Cited by 2
An ace in the hole? Opportunities and limits of using mice to understand schizophrenia neurobiology
Villarin, J. M., & Kellendonk, C. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03060-7 · Cited by 2
“Antipsychotic drugs were established to function through DA receptor antagonism during the 1970s [5, 6], supporting van Rossum ’ s 1966 hypothesis that “ overstimulation of dopamine receptors could [ … ] be part of [schizophrenia ’ s] aetiology ” [7, 8].”
Dissecting the Molecular Causes of Schizophrenia
Wildenauer, D. B., Wildenauer, D. M. B., & Schwab, S. G. (2008) · Nucleic acids and molecular biology · doi:10.1007/978-3-540-85383-1_2 · Cited by 2
“3 was first detected in 265 Irish families Straub et al. (1995) and, at the same time, in a sample from Germany consisting of 54 sibpair families (Schwab et al.”
Background
Plasma prolactin response to gonadotropin-releasing hormone during benzodiazepine treatment
Marinis, L. D., Mancini, A., Calabrò, F., D’AMICO, C., Sambo, P., Passeri, M., TOFANI, A., & Barbarino, A. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90057-1 · Cited by 2
Potential therapeutic targets for schizophrenia
Wong, A. H. C., Sanyal, S., Knapp, M., & Tol, H. H. M. V. (1999) · Emerging Therapeutic Targets · doi:10.1517/14728222.3.4.571 · Cited by 2
Enantiomeric separation of substituted 2-arylindoles on derivatised polysaccharide chiral stationary phases
Watt, A. P., Hitzel, L., & Mortishire‐Smith, R. J. (2002) · Journal of Biochemical and Biophysical Methods · doi:10.1016/s0165-022x(02)00121-5 · Cited by 2
Central Nervous System Drug Evaluation Using Positron Emission Tomography
Sekine, M., Maeda, J., Shimada, H., Nogami, T., Arakawa, R., Takano, H., Higuchi, M., Ito, H., Okubo, Y., & Suhara, T. (2011) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2011.9.1.9 · Cited by 2
Estudio funcional del receptor dopaminérgico D2 en el sistema nervioso central mediante el uso de ratones mutantes inducibles
del Pilar, E. (2012) · Cited by 2
10.3 How Antipsychotics Work: Linking Receptors to Response
Ginovart, N., & Kapur, S. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195373035.003.0038 · Cited by 2
Pharmacogenomics Applications in Psychiatric Disorders
Lencz, T., & Malhotra, A. K. (2008) · Methods in pharmacology and toxicology · doi:10.1007/978-1-59745-439-1_17 · Cited by 2
Dopamine and Response to Antipsychotic Medication
Ntephe, C., & Demjaha, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_14 · Cited by 2
Antipsychotika
Mehler‐Wex, C., Gerlach, M., & SCHIMMELMANN, B. G. (2016) · Springer eBooks · doi:10.1007/978-3-662-48624-5_6 · Cited by 2
Phosphoinositide-Specific Phospholipases C in Psychiatric Diseases and Suicide
Vasco, V. R. L. (2022) · Journal of Cellular Signaling · doi:10.33696/signaling.3.075 · Cited by 1
Dopamine in the pathophysiology and treatment of schizophrenia
Wang, K. (2024) · International Conference on Biological Engineering and Medical Science (ICBioMed) · doi:10.1117/12.3012854 · Cited by 2
“The theory gained popularity in the 1970s when research identified and established a connection between clinical efficacy and antipsychotic affinity for dopamine receptors [7].”
Background
Disinhibition of Prefrontal Cortex Neurons in Schizophrenia
Moghaddam, B., & Pehrson, A. L. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0913-8_5 · Cited by 2
Psychiatric Neuroscience: Incorporating Pathophysiology into Clinical Case Formulation
Morrow, E. M., Roffman, J. L., Wolf, D. H., & Coyle, J. T. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-04743-2.50042-1 · Cited by 2
La Reserpina Aumenta la Expresión de BDNF y PCNA, y Disminuye la de Caspasa-3, en Células Intersticiales (Células de Leydig) de Ratas
Ruiz, P., Genovese, P., Bielli, A., Herrera, E., & Pautassi, R. M. (2018) · International Journal of Morphology · doi:10.4067/s0717-95022018000300895 · Cited by 2
Burst Firing Induced by N-Methyl-D-Aspartate Requires Activation of an Electrogenic Sodium Pump in Rat Dopamine Neurons
Johnson, S. W., Seutin, V., & North, R. A. (1994) · Advances in behavioral biology · doi:10.1007/978-1-4613-0485-2_27 · Cited by 2
Diethylstilbestrol potentiation of the dopamine-elicited formation of adenosine 3?,5?-monophosphate in incubated male rat hypothalamus
Weissman, B. A. (1978) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00508300 · Cited by 2
Effect of butaclamol, a new neuroleptic, on serotoninergic mechanisms
Pugsley, T. A., & Lippmann, W. (1977) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1977.tb11269.x · Cited by 2
Classification and psychotropic drugs
Shepherd, M. (1980) · Progress in Neuro-Psychopharmacology · doi:10.1016/0364-7722(80)90015-6 · Cited by 2
Synthesis of [123I]‐3‐(4‐iodobenzyl)‐1,2,3,4‐tetrahydro‐8‐hydroxychromeno[3,4‐c]pyridin‐5‐one, a potential dopamine D4 ligand for SPECT studies
Staelens, L., Oltenfreiter, R., Cornelissen, B. T., Blanckaert, P., Vos, F. D., Deforce, D. L. D., Dierckx, R. A., & Slegers, G. (2004) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.902 · Cited by 2
Evaluation and characterisation of two zebrafish models of schizophrenia
Daggett, J. M. (2016) · St Andrews Research Repository (St Andrews Research Repository) · Cited by 2
Brain Receptors for Neurotransmitters
Peck, E. J., & Clark, J. H. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-526303-0.50024-2 · Cited by 2

Authors: Seeman, P., & Lee, T.
Affiliations: University of Toronto (CA)
ORCID: Seeman, P.
Lee, T.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1975-06-20
Volume: 188
Issue: 4194
Pages: 1217-1219
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1145194
OpenAlex: W2006122360
Cited by: 869
References: 35
Citations by year: 2026: 5 · 2025: 8 · 2024: 13 · 2023: 16 · 2022: 22 · 2021: 13 · 2020: 18 · 2019: 36 · 2018: 21 · 2017: 30 · 2016: 26 · 2015: 28 · 2014: 37 · 2013: 23 · 2012: 32
FWCI: 62.55
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: antipsychotic drugs, presynaptic dopamine release, striatum, spiperone, thioridazine, butyrophenones, phenothiazines, reserpine, pimozide, clozapine, butaclamol, stereoisomers, acetylcholine release, GABA release, schizophrenia
MeSH terms: Acetylcholine, Animals, Corpus Striatum, Dopamine, Dose-Response Relationship, Drug, Electric Stimulation, gamma-Aminobutyric Acid, Haloperidol, Humans, Male, Neurons, Neurosecretion, Schizophrenia, Tranquilizing Agents, Tritium, Rats

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Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

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