Seeman, Philip

Antipsychotic drug doses and neuroleptic/dopamine receptors

SEEMAN, P., LEE, T., CHAU-WONG, M., & WONG, K. (1976) · Nature

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 1,622

Does Fast Dissociation From the Dopamine D 2 Receptor Explain the Action of Atypical Antipsychotics?: A New Hypothesis

Kapur, S., & Seeman, P. (2001) · American Journal of Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 1,140

Multiple dopamine D4 receptor variants in the human population

Tol, H. H. M. V., Wu, C. M., Guan, H.-C., Ohara, K., Bunzow, J. R., Civelli, O., Kennedy, J., Seeman, P., Niznik, H. B., & Jovanovic, V. (1992) · Nature

Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Cited by 955

Atypical antipsychotics: Mechanism of action

Seeman, P. (2002) · The Canadian Journal of Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 899

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

Seeman, P., & Lee, T. (1975) · Science

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 869

NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D2 and serotonin 5-HT2 receptors—implications for models of schizophrenia

Kapur, S., & Seeman, P. (2002) · Molecular Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 459

Human brain dopamine receptors in children and aging adults

Seeman, P., Bzowej, N. H., Guan, H. ‐., Bergeron, C., Becker, L. E., Reynolds, G. P., Bird, E. D., Riederer, P., Jellinger, K., Watanabe, S., et al. (1987) · Synapse

Neurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

Cited by 404

Increased dopamine D 2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study

Silvestri, S., Seeman, M. V., Negrete, J.-C., Houle, S., Shammi, C. M., Remington, G. J., Kapur, S., Zipursky, R. B., Wilson, A. A., Christensen, B. K., et al. (2000) · Psychopharmacology

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 311

Schizophrenia: More dopamine, more D 2 receptors

Seeman, P., & Kapur, S. (2000) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 279

Dopaminergic supersensitivity after neuroleptics: time-course and specificity

Muller, P., & Seeman, P. (1978) · Psychopharmacology

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 271

“Breakthrough” dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time

Samaha, A.-N., Seeman, P., Stewart, J., Rajabi, H., & Kapur, S. (2007) · The Journal of Neuroscience

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 262

Anti-hyperactivity medication: methylphenidate and amphetamine

Seeman, P., & Madras, B. K. (1998) · Molecular Psychiatry

Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Cited by 252

Rapid Release of Antipsychotic Drugs From Dopamine D2 Receptors: An Explanation for Low Receptor Occupancy and Early Clinical Relapse Upon Withdrawal of Clozapine or Quetiapine

Seeman, P., & Tallerico, T. (1999) · American Journal of Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 237

All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors

Seeman, P. (2011) · CNS Neuroscience & Therapeutics

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 228

Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics

Seeman, P., Ko, F., & Tallerico, T. (2005) · Molecular Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 200

First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: a [11C]-(+)-PHNO positron emission tomography study

Willeit, M., Ginovart, N., Graff, A., Rusjan, P., Vitcu, I., Houle, S., Seeman, P., Wilson, A. A., & Kapur, S. (2008) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorMedical Imaging Techniques and Applications

Cited by 107

In vivo evidence for dopamine-mediated internalization of D2-receptors after amphetamine: differential findings with [3H]raclopride versus [3H]spiperone

Sun, W., Ginovart, N., Ko, F., Seeman, P., & Kapur, S. (2003) · Molecular Pharmacology

Neurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and Signaling

Cited by 99