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Cited by 878Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

Seeman, P., Lee, T.·1975·Science
DOI 10.1126/science.1145194
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Abstract

Neuroleptic (antipsychotic) drugs inhibited the electrically stimulated release of [3 H]dopamine from rat striatal slices. The concentrations for 50 percent inhibition (ranging from 11.5 nanomolar for spiroperidol to 800 nanomolar for thioridazine) correlated closely with the average daily dosages of 25 neuroleptic drugs used clinically for schizophrenia. The correlation includes butyrophenones, phenothiazines, reserpine, pimozide, clozapine, and (+)-butaclamol. Clinically inactive isomers [trans-thiothixene,trans-flupenthixol, and (-)-butaclamol] required 20 to 1000 times higher concentrations than the active isomers to inhibit release. Compared to the inhibition of [3 H]dopamine release, much higher neuroleptic concentrations were needed to inhibit the electrically stimulated release of other neurotransmitters—[3 H]acetylcholine, [3 H]GABA (γ-aminobutyric acid). The neuroleptic drugs may block the presynaptic coupling between impulse and neurosecretion.

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Crossref · 10.1126/science.1145194

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35 of 35 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 9

  1. Aghajanian, G. K., Frontiers in Neurology and Neuroscience Research: 4 (1974).
  2. FARNEBO, L. O., ACTA PHYSIOLOGICA SCANDINAVICA 371: 19 (1971).
  3. FARNEBO, L. O., ACTA PHYSIOLOGICA SCANDINAVICA 371: 35 (1971).
  4. Munkvad, I., The Neuroleptics. Modern Problems in Pharmacopsychiatrv 5: 44 (1970).
  5. RITCHIE, J.M., ON ACTIVE STRUCTURE OF LOCAL ANESTHETICS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 133: 241 (1961).
  6. SEEMAN, P, FEDERATION PROCEEDINGS 33: 246 (1974).
  7. SOTELO, C, ULTRASTRUCTURAL IDENTIFICATION OF NIGRAL DOPAMINERGIC CELLS IN RAT, JOURNAL DE PHARMACOLOGIE 5: 55 (1974).
  8. STAWARZ, R.J., SIGNIFICANCE OF INCREASE OF HOMOVANILLIC-ACID (HVA) CAUSED BY ANTIPSYCHOTICS IN CORPUS STRIATUM AND LIMBIC FOREBRAIN, FEDERATION PROCEEDINGS 33: 246 (1974).
  9. ZIVKOVIC, B, SPECIFIC ACTIVATION OF STRIATAL TYROSINE-HYDROXYLASE (TH) BY NEUROLEPTICS, FEDERATION PROCEEDINGS 33: 536 (1974).

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Metadata

Authors
Seeman, P., & Lee, T.
Affiliations
University of Toronto (CA)
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1975-06-20
Volume
188
Issue
4194
Pages
1217-1219
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1145194
OpenAlex
W2006122360
Cited by
869
References
35
Citations by year
2026: 5 · 2025: 8 · 2024: 13 · 2023: 16 · 2022: 22 · 2021: 13 · 2020: 18 · 2019: 36 · 2018: 21 · 2017: 30 · 2016: 26 · 2015: 28 · 2014: 37 · 2013: 23 · 2012: 32
FWCI
62.55
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
antipsychotic drugs, presynaptic dopamine release, striatum, spiperone, thioridazine, butyrophenones, phenothiazines, reserpine, pimozide, clozapine, butaclamol, stereoisomers, acetylcholine release, GABA release, schizophrenia
MeSH terms
Acetylcholine, Animals, Corpus Striatum, Dopamine, Dose-Response Relationship, Drug, Electric Stimulation, gamma-Aminobutyric Acid, Haloperidol, Humans, Male, Neurons, Neurosecretion, Schizophrenia, Tranquilizing Agents, Tritium, Rats

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