The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Draft Genome of the Filarial Nematode Parasite Brugia malayi
Open accessAbstract
Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the ∼90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict ∼11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during ∼350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.
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Conserved patterns of protein interaction in multiple species
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Self-citationExpressed Sequence Tags: Medium-Throughput Protocols
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Cited by
WormBase ParaSite − a comprehensive resource for helminth genomics
Howe, K. L., Bolt, B. J., Shafie, M., Kersey, P., & Berriman, M. (2017) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2016.11.005 · Cited by 745
Comparative genomics of the major parasitic worms
International Helminth Genomes Consortium (2019) · Nature Genetics · doi:10.1038/s41588-018-0262-1 · Cited by 560
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Metadata
- Authors
- Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J. E., Delcher, A. L., Guiliano, D. B., Miranda-Saavedra, D., Angiuoli, S. V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N. M., Wortman, J. R., Feldblyum, T., Tallon, L., Schatz, M., Shumway, M., Koo, H., Salzberg, S. L., Schobel, S., Pertea, M., Pop, M., White, O., Barton, G. J., Carlow, C. K. S., Crawford, M. J., Daub, J., Dimmic, M. W., Estes, C. F., Foster, J. M., Ganatra, M., Gregory, W. F., Johnson, N. M., Jin, J., Komuniecki, R., Korf, I., Kumar, S., Laney, S., Li, B.-W., Li, W., Lindblom, T. H., Lustigman, S., Ma, D., Maina, C. V., Martin, D. M. A., McCarter, J. P., McReynolds, L., Mitreva, M., Nutman, T. B., Parkinson, J., Peregrín-Alvarez, J. M., Poole, C., Ren, Q., Saunders, L., Sluder, A. E., Smith, K., Stanke, M., Unnasch, T. R., Ware, J., Wei, A. D., Weil, G., Williams, D. J., Zhang, Y., Williams, S. A., Fraser-Liggett, C., Slatko, B., Blaxter, M. L., & Scott, A. L.
- Venue
- Science
- Published
- 2007-09-21
- Volume
- 317
- Issue
- 5845
- Pages
- 1756-1760
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2144008452
- Cited by
- 615
- References
- 21
- FWCI
- 33.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J. E., Delcher, A. L., Guiliano, D. B., Miranda-Saavedra, D., Angiuoli, S. V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N. M., Wortman, J. R., Feldblyum, T., Tallon, L., Schatz, M., . . . Scott, A. L. (2007). Draft Genome of the Filarial Nematode Parasite Brugia malayi. Science. https://doi.org/10.1126/science.1145406
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