The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Nanomechanical Basis of Selective Gating by the Nuclear Pore Complex
Abstract
The nuclear pore complex regulates cargo transport between the cytoplasm and the nucleus. We set out to correlate the governing biochemical interactions to the nanoscopic responses of the phenylalanineglycine (FG)–rich nucleoporin domains, which are involved in attenuating or promoting cargo translocation. We found that binding interactions with the transport receptor karyopherin-β1 caused the FG domains of the human nucleoporin Nup153 to collapse into compact molecular conformations. This effect was reversed by the action of Ran guanosine triphosphate, which returned the FG domains into a polymer brush-like, entropic barrier conformation. Similar effects were observed in Xenopus oocyte nuclei in situ. Thus, the reversible collapse of the FG domains may play an important role in regulating nucleocytoplasmic transport.
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Cites
The Yeast Nuclear Pore Complex
Rout, M. P., Aitchison, J. D., Suprapto, A., Hjertaas, K., Zhao, Y., & Chait, B. T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.635 · Cited by 1,400
Speeding molecular recognition by using the folding funnel: The fly-casting mechanism
Shoemaker, B. A., Portman, J. J., & Wolynes, P. G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160259697 · Cited by 975
Molecular mechanism of the nuclear protein import cycle
Stewart, M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2114 · Cited by 919
Transport into and out of the Nucleus
Macara, I. G. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.4.570-594.2001 · Cited by 905
Nuclear Pore Complex Is Able to Transport Macromolecules with Diameters of ∼39 nm
Panté, N., & Kann, M. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-06-0308 · Cited by 776
Rexach, M., & Blobel, G. (1995) · Cell · doi:10.1016/0092-8674(95)90181-7 · Cited by 763
Nanofluidics: what is it and what can we expect from it?
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Frey, S., Richter, R. P., & Görlich, D. (2006) · Science · doi:10.1126/science.1132516 · Cited by 688
Regulating Access to the Genome
Weis, K. (2003) · Cell · doi:10.1016/s0092-8674(03)00082-5 · Cited by 674
Identification of different roles for RanGDP and RanGTP in nuclear protein import.
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Cited by
The Nuclear Pore Complex and Nuclear Transport
Wente, S. R., & Rout, M. P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000562 · Cited by 686
The Nuclear Pore Complex as a Flexible and Dynamic Gate
Knockenhauer, K. E., & Schwartz, T. U. (2016) · Cell · doi:10.1016/j.cell.2016.01.034 · Cited by 406
Schmidt, H. B., & Görlich, D. (2015) · eLife · doi:10.7554/elife.04251 · Cited by 351
Hülsmann, B. B., Labokha, A. A., & Görlich, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.019 · Cited by 310
Metadata
- Authors
- Lim, R. Y. H., Fahrenkrog, B., Köser, J., Schwarz-Herion, K., Deng, J., & Aebi, U.
- Venue
- Science
- Published
- 2007-10-26
- Volume
- 318
- Issue
- 5850
- Pages
- 640-643
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061040254
- Cited by
- 306
- References
- 29
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
