The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. We showed that DBS selectively interferes with the normal ability to slow down when faced with decision conflict. While on DBS, patients actually sped up their decisions under high-conflict conditions. This form of impulsivity was not affected by dopaminergic medication status. Instead, medication impaired patients' ability to learn from negative decision outcomes. These findings implicate independent mechanisms leading to impulsivity in treated Parkinson's patients and were predicted by a single neurocomputational model of the basal ganglia.
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Cites
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Self-citationReversal of Experimental Parkinsonism by Lesions of the Subthalamic Nucleus
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Cited by
Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415
Functional role of the supplementary and pre-supplementary motor areas
Nachev, P., Kennard, C., & Husain, M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2478 · Cited by 1,928
Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
Benabid, A. L., Chabardes, S., Mitrofanis, J., & Pollak, P. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70291-6 · Cited by 1,285
Aron, A. R. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.024 · Cited by 1,236
Subthalamic nucleus stimulation in severe obsessive-compulsive disorder
Mallet, L., Polosan, M., Jaafari, N., Baup, N., Welter, M.-L., Fontaine, D., Montcel, S. T. D., Yelnik, J., Chéreau, I., Arbus, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708514 · Cited by 965
Metadata
- Authors
- Frank, M. J., Samanta, J., Moustafa, A. A., & Sherman, S. J.
- Venue
- Science
- Published
- 2007-11-23
- Volume
- 318
- Issue
- 5854
- Pages
- 1309-1312
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983297775
- Cited by
- 1,120
- References
- 35
- FWCI
- 34.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frank, M. J., Samanta, J., Moustafa, A. A., & Sherman, S. J. (2007). Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism. Science. https://doi.org/10.1126/science.1146157
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
