Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., & Thomas, G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00220-x · Cited by 1,043

Rheb Binds and Regulates the mTOR Kinase

Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., & Avruch, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.053 · Cited by 1,005

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., & Pan, D. (2003) · Nature Cell Biology · doi:10.1038/ncb999 · Cited by 924

The expanding TOR signaling network

Martin, D. E., & Hall, M. N. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.008 · Cited by 496

Rheb fills a GAP between TSC and TOR

Manning, B. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.09.003 · Cited by 483

Functions of the Hsp90-Binding FKBP Immunophilins

Guy, N. C., Garcia, Y. A., Sivils, J. C., Galigniana, M. D., & Cox, M. B. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-11731-7_2 · Cited by 36

Risk factors for pterygium: Latest research progress on major pathogenesis

Ding, P., Wang, R., & He, Y. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.109900 · Cited by 42

The abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin, amino acids, and age

Suryawan, A., & Davis, T. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00428.2010 · Cited by 34

Intracellular parasitism withToxoplasma gondiistimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1

Wang, Y., Weiss, L. M., & Orlofsky, A. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01305.x · Cited by 34

Recent Advancements in Small Molecule Inhibitors of Insulin–like Growth Factor-1 Receptor (IGF-1R) Tyrosine Kinase as Anticancer agents

Negi, A., Ramarao, P., & Kumar, R. (2013) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557511313050004 · Cited by 33

Phosphatidic acid: biosynthesis, pharmacokinetics, mechanisms of action and effect on strength and body composition in resistance-trained individuals

Bond, P. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0166-6 · Cited by 33

Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway

Xiao, P., Xie, Z., Kuang, Y., Liu, S., Zeng, C., Li, P., & Liu, E. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.031 · Cited by 34

eIF4A inactivates TORC1 in response to amino acid starvation

Tsokanos, F., Albert, M., Demetriades, C., Spirohn, K., Boutros, M., & Teleman, A. A. (2016) · The EMBO Journal · doi:10.15252/embj.201593118 · Cited by 29

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)

Feng, D., Youn, D. Y., Zhao, X., Gao, Y., Quinn, W. J., Xiaoli, A. M., Sun, Y., Birnbaum, M. J., Pessin, J. E., & Yang, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126240 · Cited by 33

Zexie Tang targeting FKBP38/mTOR/SREBPs pathway improves hyperlipidemia

Xie, Z., Li, E.-W., Gao, G., Yue-Yue, D. U., Wang, M., Wang, H., Wang, P., Qiao, Y., Su, Y., Xu, J., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115101 · Cited by 30

Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies

Xi, Y., & Chen, Y. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25159 · Cited by 31

Distinctive Responses to Nitrogen Starvation in the Dominant Active Mutants of the Fission Yeast Rheb GTPase

Murai, T., Nakase, Y., Fukuda, K., Chikashige, Y., Tsutsumi, C., Hiraoka, Y., & Matsumoto, T. (2009) · Genetics · doi:10.1534/genetics.109.105379 · Cited by 31

Signal transduction pathways of mantle cell lymphoma: A phosphoproteome‐based study

Cecconi, D., Zamò, A., Bianchi, E., Parisi, A., Barbi, S., Milli, A., Rinalducci, S., Rosenwald, A., Hartmann, E., Zolla, L., et al. (2008) · PROTEOMICS · doi:10.1002/pmic.200800080 · Cited by 31

Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules

Gunn, R. M., & Hailes, H. (2008) · Journal of chemical biology · doi:10.1007/s12154-008-0008-0 · Cited by 35

Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis

Wang, X., Lai, P., Zhang, Z., Huang, M., Wang, L., YIN, M., Jin, D.-D., Zhou, R., & Bai, X. (2014) · Oncology Reports · doi:10.3892/or.2014.3182 · Cited by 29

Quantification of the effect of amino acids on an integrated mTOR and insulinsignaling pathway

Vinod, P. K. U., & Venkatesh, K. V. (2009) · Molecular BioSystems · doi:10.1039/b816965a · Cited by 30

FKBP8 is a novel molecule that participates in the regulation of the autophagic pathway

Aguilera, M. O., Robledo, E., Melani, M., Wappner, P., & Colombo, M. I. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119212 · Cited by 32

mTOR Signaling as a Target of Amino Acid Treatment of the Age-Related Sarcopenia

D’Antona, G., & Nisoli, E. (2010) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000319998 · Cited by 29

Unraveling the Role of Peptidyl-Prolyl Isomerases in Neurodegeneration

Gérard, M., Deleersnijder, A., Demeulemeester, J., Debyser, Z., & Baekelandt, V. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8184-2 · Cited by 29

Translating Translation to Mechanisms of Cardiac Hypertrophy

Zeitz, M. J., & Smyth, J. W. (2020) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd7010009 · Cited by 31

Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice

Li, K., Zhang, Y., Liang, K., Xu, S., Zhou, X. J., Tan, K. W., Lin, J., Bai, X. C., & Yang, C. L. (2017) · Scientific Reports · doi:10.1038/srep42655 · Cited by 28

FKBP38-Bcl-2 interaction: a novel link to chemoresistance

Choi, B., & Yoon, H. S. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.04.013 · Cited by 28

Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review

Levitt, D. E., Luk, H., & Vingren, J. L. (2022) · Biomolecules · doi:10.3390/biom13010002 · Cited by 33

The FKBP–Rapamycin Binding Domain of Human TOR Undergoes Strong Conformational Changes in the Presence of Membrane Mimetics with and without the Regulator Phosphatidic Acid

Camargo, D. C. R., Link, N. M., & Dames, S. A. (2012) · Biochemistry · doi:10.1021/bi3002133 · Cited by 27

Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells

Zheng, H., Liu, A., Liu, B., Li, M., Yu, H., & Luo, X. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.05.004 · Cited by 25

Ca2+/S100 proteins inhibit the interaction of FKBP38 with Bcl-2 and Hsp90

Shimamoto, S., Tsuchiya, M., Yamaguchi, F., Kubota, Y., Tokumitsu, H., & Kobayashi, R. (2013) · Biochemical Journal · doi:10.1042/bj20130924 · Cited by 25

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance

Zhao, Z., Chen, Q., Xiang, X., Dai, W., Fang, W., Cui, K., Li, B., Liu, Q., Liu, Y., Shen, Y.-N., et al. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202309090 · Cited by 24

Unraveling the multifaceted nature of the nuclear function of mTOR

Torres, A. S., & Holz, M. K. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118907 · Cited by 23

Signaling Functions of Intramembrane Aspartyl-Proteases

Papadopoulou, A. A., & Fluhrer, R. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.591787 · Cited by 23

Noncanonical FK506-Binding Protein BDBT Binds DBT to Enhance Its Circadian Function and Forms Foci at Night

Fan, J.-Y., Agyekum, B., Venkatesan, A., Hall, D. R., Keightley, A., Bjes, E. S., Bouyain, S., & Price, J. L. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.004 · Cited by 24

IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1

Jia, C.-H., Li, M., Liu, J., Zhao, L., Lin, J., Lai, P.-L., Zhou, X., Zhang, Y., Chen, Z.-G., Li, H.-Y., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.115 · Cited by 24

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice

Liu, W., Wang, Z., Yang, J., Wang, Y., Li, K., Huang, B., Yan, B., Wang, T., Li, M., Zou, Z., et al. (2019) · Open Biology · doi:10.1098/rsob.180262 · Cited by 24

Protein Phosphorylation as a Key Mechanism of mTORC1/2 Signaling Pathways

Tchevkina, E. M., & Komelkov, A. V. (2012) · InTech eBooks · doi:10.5772/48274 · Cited by 26

The Long-HER Study: Clinical and Molecular Analysis of Patients with HER2+ Advanced Breast Cancer Who Become Long-Term Survivors with Trastuzumab-Based Therapy

Gámez‐Pozo, A., Carrión, R. M. P., Manso, L., Crespo, C., Mendiola, C., López‐Vacas, R., Berges‐Soria, J., Álvarez, I., Vila, M. M., Calero, J. L. B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109611 · Cited by 24

mTOR Signaling in Lymphangioleiomyomatosis

Kristof, A. S. (2010) · Lymphatic Research and Biology · doi:10.1089/lrb.2009.0019 · Cited by 23

Role of the Mammalian Target of Rapamycin (mTOR) Complexes in Pancreatic β-Cell Mass Regulation

Bartolomé, A., & Guillén, C. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800174-5.00017-x · Cited by 24

CD206+ M2-like macrophages protect against intervertebral disc degeneration partially by targeting R-spondin-2

Li, X.-C., Wang, W., Jiang, C., Chen, Y.-L., Chen, J. F., Zhang, Z., Luo, S., Chen, R., Mo, P.-F., Zhong, M., et al. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.09.010 · Cited by 22

Lysosomal accumulation of mTOR is enhanced by rapamycin

Ohsaki, Y., Suzuki, M., Shinohara, Y., & Fujimoto, T. (2010) · Histochemistry and Cell Biology · doi:10.1007/s00418-010-0759-x · Cited by 22

mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo

Zhang, Y., Xu, S., Lin, J., Yao, G., Han, Z., Liang, B., Zou, Z., Chen, Z., Song, Q., Dai, Y., et al. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2270-7 · Cited by 22

The Interplay between Autophagy and Mitochondria in Cancer

Zdanowicz, A., & Grosicka-Maciąg, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179143 · Cited by 23

Biological relevance of Hsp90‐binding immunophilins in cancer development and treatment

Mazaira, G. I., Camisay, M. F., Leo, S. A. D., Erlejman, A. G., & Galigniana, M. D. (2015) · International Journal of Cancer · doi:10.1002/ijc.29509 · Cited by 21

Risedronate inhibits bone marrow mesenchymal stem cell adipogenesis and switches RANKL/OPG ratio to impair osteoclast differentiation

Jin, J., Wang, L., Wang, X., Lai, P., Huang, M., Jin, D., Zhong, Z., Chen, J.-T., & Bai, X. (2012) · Journal of Surgical Research · doi:10.1016/j.jss.2012.03.018 · Cited by 21

The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability

Choi, M.-S., Min, S., Jung, H., Lee, J. D., Lee, T. H., Lee, H. K., & Yoo, O.-J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.02.037 · Cited by 21

Therapeutic opportunities for pain medicines via targeting of specific translation signaling mechanisms

Megat, S., & Price, T. J. (2018) · Neurobiology of Pain · doi:10.1016/j.ynpai.2018.02.001 · Cited by 19

Multi-Omics Analysis of the Expression and Prognosis for FKBP Gene Family in Renal Cancer

Sun, Z., Qin, X., Fang, J., Tang, Y., & Fan, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.697534 · Cited by 22

Mechanistic target of rapamycin in regulating macrophage function in inflammatory cardiovascular diseases

Mangione, M. C., Wen, J., & Cao, D. J. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.10.011 · Cited by 20

Exploring the significance of extracellular vesicles: Key players in advancing cancer and possible theranostic tools

Patel, B. B., Gaikwad, S. R., & Prasad, S. (2024) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2024.04.005 · Cited by 20

To eat or not to eat mitochondria? How do host cells cope with mitophagy upon bacterial infection?

Verbeke, J., Bolle, X. D., & Arnould, T. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011471 · Cited by 20

Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration

Shu, Y., Liu, Z., Zhou, Y., Luo, Q., Hu, M., Wang, G., & Huang, S.-H. (2012) · Indian Journal of Pathology and Microbiology · doi:10.4103/0377-4929.97849 · Cited by 19

NMR- and Circular Dichroism-monitored Lipid Binding Studies Suggest a General Role for the FATC Domain as Membrane Anchor of Phosphatidylinositol 3-Kinase-related Kinases (PIKK)

Sommer, L. A. M., Schaad, M., & Dames, S. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467233 · Cited by 22

Shp2 regulates chlorogenic acid-induced proliferation and adipogenic differentiation of bone marrow-derived mesenchymal stem cells in adipogenesis

Zhou, R., DENG, M.-T., CHEN, L.-Y., FANG, N., DU, C., CHEN, L.-P., Zou, Y., Dai, J., ZHU, M.-L., Wang, W. J., et al. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3285 · Cited by 19

Histocompatibility Minor 13 (HM13), targeted by miR-760, exerts oncogenic role in breast cancer by suppressing autophagy and activating PI3K-AKT-mTOR pathway

Yang, H., Li, Z., Wang, Z., Zhang, X., Dai, X., Zhou, G., & Ding, Q. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05154-4 · Cited by 19

Exploration of Involved Key Genes and Signaling Diversity in Brain Tumors

Nasser, M. M., & Mehdipour, P. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0498-9 · Cited by 18

FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story

Chambraud, B., Byrne, C., Méduri, G., Baulieu, E. E., & Giustiniani, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031738 · Cited by 18

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Li, M., Huang, W., Zhang, Y., Du, Y., Zhao, S., Wang, L., Sun, Y., Sha, B., Yan, J., Ma, Y., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06808-1 · Cited by 17

Regulation of Mammalian Target of Rapamycin Complex 1 by Bcl-2 and Bcl-XL Proteins

Zou, H., Lai, Y., Zhao, X., Yan, G., Ma, D., Cárdenes, N., Shiva, S., Liu, Y., Bai, X., Jiang, Y., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.505370 · Cited by 17

Prohibitin regulates mTOR pathway via interaction with FKBP8

Zhang, J., Yin, Y., Wang, J., Zhang, J., Liu, H., Feng, W., Yang, W., Zetter, B. R., & Xu, Y. (2020) · Frontiers of Medicine · doi:10.1007/s11684-020-0805-6 · Cited by 17

Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation

da Silva, E. F., Fong, J., Roye‐Azar, A., Nadi, A., Drouillard, C., Pillon, A., & Porter, L. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.806521 · Cited by 17

Linking nutrients to growth

Zinzalla, V., & Hall, M. N. (2008) · Nature · doi:10.1038/454287a · Cited by 17

Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1

He, X., Wang, Q.-X., Wei, D., Lin, Y., Zhang, X., Wu, Y., Qian, X., Lin, Z., Xiao, B.-B., Wu, Q., et al. (2025) · Cell Research · doi:10.1038/s41422-025-01110-x · Cited by 21

Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting

Cicco, M. D., Rahim, M. S. A., & Dames, S. A. (2015) · Membranes · doi:10.3390/membranes5040553 · Cited by 19

The FKBP38 Catalytic Domain Binds to Bcl-2 via a Charge-sensitive Loop

Haupt, K., Jahreis, G., Linnert, M., Maestre-Martínez, M., Malešević, M., Pechstein, A., Edlich, F., & Lücke, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.317214 · Cited by 16

SCP, a polysaccharide from Schisandra chinensis, induces apoptosis in human renal cell carcinoma Caki-1 cells through mitochondrial-dependent pathway via inhibition of ERK activation

Liu, S.-J., Qu, H.-M., & Ren, Y. (2014) · Tumor Biology · doi:10.1007/s13277-014-1699-1 · Cited by 16

Rheb in neuronal degeneration, regeneration, and connectivity

Potheraveedu, V. N., Schöpel, M., Stoll, R., & Heumann, R. (2017) · Biological Chemistry · doi:10.1515/hsz-2016-0312 · Cited by 18

Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1

Chalkiadaki, K., Hooshmandi, M., Lach, G., Statoulla, E., Simbriger, K., Amorim, I. S., Kouloulia, S., Zafeiri, M., Pothos, P., Bonneil, É., et al. (2022) · Brain · doi:10.1093/brain/awac398 · Cited by 15

The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development

Ma, Q., Chen, G., Li, Y., Guo, Z., & Zhang, X. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.04.041 · Cited by 18

Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

Hu, L. T., Chen, F., Wu, C., Wang, J., Chen, S., Li, X., Wang, J., Wu, L., Ding, J., Wang, J.-C., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103177 · Cited by 14

Effects of RhebL1 silencing on the mTOR pathway

Bonneau, A. R., & Parmar, N. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-0960-6 · Cited by 15

The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells

Li, S., Liang, Y., Wu, M., Wang, X., Fu, H., Chen, Y., & Wang, Z. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-30 · Cited by 15

Early and delayed intervention with Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice

Patlolla, J. M. R., Kopelovich, L., Li, Q., Zhang, Y., Kumar, G., Madka, V., Mohammed, A., Biddick, L., Sadeghi, M., Lightfoot, S. A., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.4277 · Cited by 15

Oncolytic Avian Reovirus p17-Modulated Inhibition of mTORC1 by Enhancement of Endogenous mTORC1 Inhibitors Binding to mTORC1 To Disrupt Its Assembly and Accumulation on Lysosomes

Li, J., Huang, W., Liao, T., Nielsen, B. L., & Liu, H. (2022) · Journal of Virology · doi:10.1128/jvi.00836-22 · Cited by 14

Mammalian Target of Rapamycin Complex I (mTORC1) Activity in Ras Homologue Enriched in Brain (Rheb)-Deficient Mouse Embryonic Fibroblasts

Groenewoud, M. J., Goorden, S. M. I., Kassies, J., Berkel, W. P.-V., Lamb, R. F., Elgersma, Y., & Zwartkruis, F. J. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081649 · Cited by 16

A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding

Maestre-Martínez, M., Haupt, K., Edlich, F., Neumann, P., Parthier, C., Stubbs, M. T., Fischer, G. S., & Lücke, C. (2010) · Journal of Molecular Recognition · doi:10.1002/jmr.1020 · Cited by 14

New structural aspects of FKBP38 activation

Maestre-Martínez, M., Haupt, K., Edlich, F., Jahreis, G., Jarczowski, F., Erdmann, F., Fischer, G. S., & Lücke, C. (2010) · Biological Chemistry · doi:10.1515/bc.2010.122 · Cited by 14

mTOR

Robitaille, A. M., & Hall, M. N. (2008) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a000094.01 · Cited by 13

Synthesis of the Rheb and K‐Ras4B GTPases

Chen, Y., Koch, S., Uhlenbrock, K., Weise, K., Das, D., Gremer, L., Brunsveld, L., Wittinghofer, A., Winter, R., Triola, G., et al. (2010) · Angewandte Chemie · doi:10.1002/ange.201001884 · Cited by 13

Ethyl Pyruvate Preserves IGF-I Sensitivity toward mTOR Substrates and Protein Synthesis in C2C12 Myotubes

Frost, R. A., Pereyra, E., & Lang, C. H. (2010) · Endocrinology · doi:10.1210/en.2010-0248 · Cited by 12

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targetsPreprint

Kratzel, A., Kelly, J. N., Brüggemann, Y., Portmann, J., V’kovski, P., Tödt, D., Ebert, N., Steinmann, E., Dijkman, R., Zimmer, G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.24.432634 · Cited by 12

Dietary protein re-alimentation following restriction improves protein deposition via changing amino acid metabolism and transcriptional profiling of muscle tissue in growing beef bulls

Wang, J., Shen, C., Zhao, G., Hanigan, M. D., & Li, M. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.04.028 · Cited by 12

CircSATB1 Promotes Colorectal Cancer Liver Metastasis through Facilitating FKBP8 Degradation via RNF25‐Mediated Ubiquitination

Zhang, C., Tian, C., Zhu, R., Chen, C., Jin, C., Wang, X., Sun, L., Peng, W., Ji, D., Zhang, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202406962 · Cited by 11

Esterase D stabilizes FKBP25 to suppress mTORC1

Yang, Y., Chen, X., Yao, W., Cui, X., Li, N., Lin, Z., Zhao, B., & Miao, J. (2021) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-021-00297-2 · Cited by 10

How does the mammalian target of rapamycin (mTOR) influence CD8 T-cell differentiation?

Salmond, R. J., & Zamoyska, R. (2010) · Cell Cycle · doi:10.4161/cc.9.15.12358 · Cited by 10

FKBP8 variants are risk factors for spina bifida

Tian, T., Cao, X., Kim, S., Lin, Y. L., Steele, J., Cabrera, R. M., Karki, M., Yang, W., Marini, N. J., Hoffman, E. N., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa211 · Cited by 9

Tuberous sclerosis complex: everything old is new again

Ess, K. C. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9014-y · Cited by 9

TNFAIP8L2 maintains hair cell function and regulates age-related hearing loss via mTORC1 signaling

Li, W., Li, Y., Wang, M., Liu, H., Hong, G., Jiang, L., Liu, Z., Wu, Y., Yuan, L., Zhao, X., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.03.046 · Cited by 8

Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling

Rahman, M., Nguyen, T. M., Lee, G. J., Kim, B., Park, M. K., & Lee, C. H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031489 · Cited by 7

Novel Stem Cell Strategies with mTOR

Maiese, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00020-7 · Cited by 8

Smyd1C Mediates CD8 T Cell Death via Regulation of Bcl2-Mediated Restriction of outer Mitochondrial Membrane Integrity

Nie, H., Rathbun, G. A., & Tucker, H. O. (2017) · Journal of Cell Signaling · doi:10.4172/2576-1471.1000163 · Cited by 8

Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays

Shams, R. S., Ito, Y., & Miyatake, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168766 · Cited by 8

The past-tense debate

Pinker, S. A., & Ullman, M. T. (2002) · Cited by 8

Translational Control by Amino Acids and Energy

Thedieck, K., & Hall, M. N. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00274-6 · Cited by 8

Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry

Annunziato, S., Quan, C., Donckele, E. J., Lamberto, I., Bunker, R. D., Zlotosch, M., Schwander, L., Murthy, A., Wiedmer, L., Staehly, C., et al. (2026) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01738-8 · Cited by 9

The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues

Carrasco, R. R., Pérez-Pandolfo, S., Freire, S. S., Romero, N. M., Bhujabal, Z., Johansen, T., Wappner, P., & Melani, M. (2020) · Traffic · doi:10.1111/tra.12777 · Cited by 8

FKBP38 suppresses endometrial cancer cell proliferation and metastasis by inhibiting the mTOR pathway

Yan, Y., Wang, S., Zhang, Z., Tang, M., Zhao, A. Z., Li, Z., Wu, X., & Li, F. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.109891 · Cited by 7

Role of mTOR1 and mTOR2 complexes in MEG-01 cell physiology

López, E., Berna‐Erro, A., López, J. J., Granados, M. P., Bermejo, N., Brull, J. M., Salido, G. M., Rosado, J. A., & Redondo, P. C. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-09-0727 · Cited by 7

Investigation of cytotoxic and apoptotic effects of disodium pentaborate decahydrate on ovarian cancer cells and assessment of gene profiling

Günel, N. S., Yıldırım, N., Özateş, N. P., Oktay, L. M., Bağca, B. G., Söğütlü, F., Özsaran, A., Korkmaz, M., & Avcı, Ç. B. (2022) · Medical Oncology · doi:10.1007/s12032-022-01870-1 · Cited by 6

Molecular Characterization and Expression Pattern of Rheb Gene in Inner Mongolia Cashmere Goat (Capra hircus)

Xu, Z., Yang, J.-F., Wang, X., Liang, Y., Wu, M., Shi, J., Zhang, T., Yin, Q. I. N., Li, S., Hao, X., et al. (2011) · Agricultural Sciences in China · doi:10.1016/s1671-2927(11)60138-7 · Cited by 6

Temporal Expression Pattern of Fkbp8 in Rodent Cochlea

Żak, M., Breß, A., Pfister, M., & Blin, N. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000335789 · Cited by 6

The Roles of Ras Family Small GTPases in Breast Cancer

Hanker, A. B., & Der, C. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00322-3 · Cited by 6

Identification of proteins suppressing the functions of oncogenic phosphatase of regenerating liver 1 and 3

Lee, J.-D., Jung, H., & Min, S. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3722 · Cited by 6

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

Uhlenbrock, K., Weiwad, M., Wetzker, R., Fischer, G. S., Wittinghofer, A., & Rubio, I. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.02.015 · Cited by 47

The Switch I Region of Rheb Is Critical for Its Interaction with FKBP38

Ma, D., Bai, X., Guo, S., & Jiang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802356200 · Cited by 56

Regulating the Regulators

Ray, L. B. (2007) · Science s STKE · doi:10.1126/stke.4122007tw418 · Cited by 1

Molecular Mechanisms of Rheb's Regulation of Apoptosis by FKBP38

Zhang, T. (2011) · Journal of Henan University

Rheb GTPase Controls Apoptosis by Regulating Interaction of FKBP38 with Bcl-2 and Bcl-XL

Ma, D., Bai, X., Zou, H., Lai, Y., & Jiang, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092353 · Cited by 48