Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., & Thomas, G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00220-x · Cited by 1,043

Rheb Binds and Regulates the mTOR Kinase

Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., & Avruch, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.053 · Cited by 1,005

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., & Pan, D. (2003) · Nature Cell Biology · doi:10.1038/ncb999 · Cited by 924

The expanding TOR signaling network

Martin, D. E., & Hall, M. N. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.008 · Cited by 496

Rheb fills a GAP between TSC and TOR

Manning, B. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.09.003 · Cited by 483

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

Huang, J., & Manning, B. D. (2008) · Biochemical Journal · doi:10.1042/bj20080281 · Cited by 1,237

mTOR signaling: At the crossroads of plasticity, memory and disease

Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

Kalender, A., Selvaraj, A., Kim, S. Y., Gulati, P., Brûlé, S., Viollet, B., Kemp, B. E., Bardeesy, N., Dennis, P., Schlager, J. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.014 · Cited by 889

The PTEN–PI3K pathway: of feedbacks and cross-talks

Carracedo, A., & Pandolfi, P. P. (2008) · Oncogene · doi:10.1038/onc.2008.247 · Cited by 908

Regulation of mTORC1 by PI3K signaling

Dibble, C. C., & Cantley, L. C. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.06.002 · Cited by 854

FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

Pei, H., Li, L., Fridley, B. L., Jenkins, G. D., Kalari, K. R., Lingle, W., Petersen, G., Lou, Z., & Wang, L. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.016 · Cited by 709

Targeting protein prenylation for cancer therapy

Berndt, N., Hamilton, A. D., & Sebti, S. M. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3151 · Cited by 614

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

Zhang, C., Jiang, B., Li, M., Zhu, M., Peng, Y., Zhang, Y., Wu, Y., Li, T. Y., Yu, L., Lu, Z., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.014 · Cited by 565

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

Foster, K. G., & Fingar, D. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.094003 · Cited by 545

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

Zhang, H., Lin, C., Zeng, C., Wang, Z., Wang, H., Lu, J., Liu, X., Shao, Y. X., Zhao, C. M., Pan, J., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213450 · Cited by 503

PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control

Georgescu, M. (2010) · Genes & Cancer · doi:10.1177/1947601911407325 · Cited by 507

Rapamycin and mTOR kinase inhibitors

Ballou, L. M., & Lin, R. Z. (2008) · Journal of Chemical Biology · doi:10.1007/s12154-008-0003-5 · Cited by 458

FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy

Bhujabal, Z., Birgisdottir, Å. B., Sjøttem, E., Brenne, H. B., Øvervatn, A., Habisov, S., Kirkin, V., Lamark, T., & Johansen, T. (2017) · EMBO Reports · doi:10.15252/embr.201643147 · Cited by 430

The tuberous sclerosis complex

Orlova, K. A., & Crino, P. B. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05117.x · Cited by 414

Amino acid regulation of TOR complex 1

Avruch, J., Long, X., Ortiz-Vega, S., Rapley, J., Papageorgiou, A., & Dai, N. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90645.2008 · Cited by 400

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

Gulati, P., Gaspers, L. D., Dann, S. G., Joaquin, M., Nobukuni, T., Natt, F., Kozma, S. C., Thomas, A. P., & Thomas, G. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.002 · Cited by 371

Direct control of mitochondrial function by mTOR

Ramanathan, A., & Schreiber, S. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912074106 · Cited by 367

The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells

Nepstad, I., Hatfield, K. J., Grønningsæter, I. S., & Reikvam, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082907 · Cited by 365

Making synaptic plasticity and memory last: mechanisms of translational regulationPreprint

Richter, J. D., & Klann, E. (2009) · Genes & Development · doi:10.1101/gad.1735809 · Cited by 350

FKBP Family Proteins: Immunophilins with Versatile Biological Functions

Kang, C., Ye, H., Dhe‐Paganon, S., & Yoon, H. S. (2008) · Neurosignals · doi:10.1159/000123041 · Cited by 331

Regulation of Tissue Growth through Nutrient Sensing

Hietakangas, V., & Cohen, S. M. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134815 · Cited by 341

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

McCubrey, J. A., Steelman, L. S., Chappell, W. H., Abrams, S. L., Franklin, R. A., Montalto, G., Cervello, M., Libra, M., Candido, S., Malaponte, G., et al. (2012) · Oncotarget · doi:10.18632/oncotarget.659 · Cited by 317

mTOR and the control of whole body metabolism

Polak, P., & Hall, M. N. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.024 · Cited by 310

Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia

Park, S., Chapuis, N., Tamburini, J., Bardet, V., Cornillet‐Lefèbvre, P., Willems, L., Green, A. S., Mayeux, P., Lacombe, C., & Bouscary, D. (2009) · Haematologica · doi:10.3324/haematol.2009.013797 · Cited by 315

Rapamycin and Glucose-Target of Rapamycin (TOR) Protein Signaling in Plants

Xiong, Y., & Sheen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.300749 · Cited by 312

Leucine and mTORC1: a complex relationship

Dodd, K. M., & Tee, A. R. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00525.2011 · Cited by 310

Protein Kinases and Phosphatases in the Control of Cell Fate

Bononi, A., Agnoletto, C., Marchi, E. D., Marchi, S., Patergnani, S., Bonora, M., Giorgi, C., Missiroli, S., Poletti, F., Rimessi, A., et al. (2011) · Enzyme Research · doi:10.4061/2011/329098 · Cited by 294

Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s)

Foster, D. A., Yellen, P., Xu, L., & Saqcena, M. (2010) · Genes & Cancer · doi:10.1177/1947601910392989 · Cited by 279

L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.

Wang, Q., & Holst, J. (2015) · Europe PMC (PubMed Central) · Cited by 273

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

Melser, S., Chatelain, É. H., Lavie, J., Mahfouf, W., José, C., Obre, É., Goorden, S. M. I., Priault, M., Elgersma, Y., Rezvani, H. R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.014 · Cited by 270

Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms

Dunlop, E. A., & Tee, A. R. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.01.012 · Cited by 263

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

Chen, L., Xu, B., Liu, L., Luo, Y., Zhou, H., Chen, W., Shen, T., Han, X., Kontos, C. D., & Huang, S. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.032 · Cited by 252

Regulation of PRKN-independent mitophagy

Terešak, P., Lapão, A., Subic, N., Boya, P., Elazar, Z., & Simonsen, A. (2021) · Autophagy · doi:10.1080/15548627.2021.1888244 · Cited by 256

Autophagy, lipophagy and lysosomal lipid storage disorders

Ward, C., Martínez-López, N., Otten, E. G., Carroll, B., Maetzel, D., Singh, R., Sarkar, S., & Korolchuk, V. I. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.006 · Cited by 254

A comprehensive map of the mTOR signaling network

Caron, É., Ghosh, S., Matsuoka, Y., Ashton‐Beaucage, D., Therrien, M., Lemieux, S., Perreault, C., Roux, P. P., & Kitano, H. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.108 · Cited by 248

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

Chen, L., Xu, B., Liu, L., Luo, Y., Yin, J., Zhou, H., Chen, W., Shen, T., Han, X., & Huang, S. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.36 · Cited by 236

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

Hoeffer, C. A., Tang, W., Wong, H., Santillan, A., Patterson, R. J., Martinez, L. A., Tejada-Simon, M. V., Paylor, R. E., Hamilton, S. L., & Klann, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.037 · Cited by 240

Amino Acid Signaling in TOR Activation

Kim, J., & Guan, K. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062209-094414 · Cited by 239

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

Rosner, M., & Hengstschläger, M. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn192 · Cited by 237

Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats

Mai, Q., Zhang, Z., Xu, S. H., Lu, M., Zhou, R., Zhao, L., Jia, C., Wen, Z., Jin, D., & Bai, X. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23206 · Cited by 229

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

Buchkovich, N. J., Yu, Y., Zampieri, C. A., & Alwine, J. C. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1855 · Cited by 238

Perifosine: Update on a novel Akt inhibitor

Gills, J. J., & Dennis, P. A. (2009) · Current Oncology Reports · doi:10.1007/s11912-009-0016-4 · Cited by 221

Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

Foster, D. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.02.009 · Cited by 228

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

Martelli, A. M., Evangelisti, C., Chappell, W. H., Abrams, S. L., Bäsecke, J., Stivala, F., Donia, M., Fagone, P., Nicoletti, F., Libra, M., et al. (2011) · Leukemia · doi:10.1038/leu.2011.46 · Cited by 207

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

Maiese, K. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12804 · Cited by 202

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

Green, A. S., Chapuis, N., Trovati Maciel, T., Willems, L., Lambert, M., Arnoult, C., Boyer, O., Bardet, V., Park, S., Foretz, M., et al. (2010) · Blood · doi:10.1182/blood-2010-02-269837 · Cited by 199

Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein

Sato, T., Nakashima, A., Guo, L., & Tamanoi, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809207200 · Cited by 196

Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

Lee, M. N., Ha, S. H., Kim, J. J., Koh, A., Lee, C. S., Kim, J. H., Jeon, H., Kim, D., Suh, P., & Ryu, S. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00165-09 · Cited by 196

mTOR Signaling, Function, Novel Inhibitors, and Therapeutic Targets

Watanabe, R., Liu, W., & Huang, J. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.089623 · Cited by 186

The mTOR pathway and its role in human genetic diseases

ROSNER, M., Hanneder, M., Siegel, N., Valli, A., Fuchs, C., & HENGSTSCHLAGER, M. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.06.001 · Cited by 185

Integrating Body and Organ Size in Drosophila: Recent Advances and Outstanding Problems

Mirth, C. K., & Shingleton, A. W. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00049 · Cited by 180

Phospholipase D1 is an effector of Rheb in the mTOR pathway

Sun, Y., Fang, Y., Yoon, M., Zhang, C., Roccio, M., Zwartkruis, F. J. T., Armstrong, M. D., Brown, H. A., & Chen, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712268105 · Cited by 184

Regulation of Body Size and Growth Control

Texada, M. J., Koyama, T., & Rewitz, K. (2020) · Genetics · doi:10.1534/genetics.120.303095 · Cited by 177

Characterization of TCTP, the Translationally Controlled Tumor Protein, fromArabidopsis thaliana

Berkowitz, O., Jost, R., Pollmann, S., & Masle, J. (2008) · The Plant Cell · doi:10.1105/tpc.108.061010 · Cited by 173

Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

Hornberger, T. A. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.05.007 · Cited by 170

Regulation and Function of Protein Kinases and Phosphatases

Cheng, H., Qi, R. Z., Paudel, H. K., & Zhu, H. (2011) · Enzyme Research · doi:10.4061/2011/794089 · Cited by 179

HER3 Is a Determinant for Poor Prognosis in Melanoma

Reschke, M., Mihic‐Probst, D., van der Horst, E. H., Knyazev, P. G., Wild, P. J., Hutterer, M., Meyer, S., Dummer, R., Moch, H., & Ullrich, A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0186 · Cited by 170

Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth

Acosta-Jaquez, H. A., Keller, J. A., Foster, K. G., Üstünel, B. E., Soliman, G. A., Feener, E. P., Ballif, B. A., & Fingar, D. C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01665-08 · Cited by 171

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia

Willems, L., Chapuis, N., Puissant, A., Maciel, T. T., Green, A. S., Jacque, N., Vignon, C., Park, S., Guichard, S. M., Hérault, O., et al. (2011) · Leukemia · doi:10.1038/leu.2011.339 · Cited by 172

The Rheb–mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord

Codeluppi, S., Svensson, C. I., Hefferan, M. P., Valencia, F., Silldorff, M. D., Oshiro, M., Maršala, M., & Pasquale, E. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4103-08.2009 · Cited by 159

Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia

Chapuis, N., Tamburini, J., Green, A. S., Vignon, C., Bardet, V., Neyret, A., Pannetier, M., Willems, L., Park, S., Macone, A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1102 · Cited by 163

Mammalian Target of Rapamycin: Hitting the Bull′s‐Eye for Neurological Disorders

Chong, Z. Z., Shang, Y., Zhang, L., Wang, S., & Maiese, K. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.6.14787 · Cited by 149

Atg5 Regulates Phenethyl Isothiocyanate-induced Autophagic and Apoptotic Cell Death in Human Prostate Cancer Cells

Bommareddy, A., Hahm, E.-R., Xiao, D., Powolny, A., Fisher, A. L., Jiang, Y., & Singh, S. V. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4344 · Cited by 152

Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

Wang, X., Fonseca, B. D., Tang, H., Liu, R., Elia, A., Clemens, M. J., Bommer, U., & Proud, C. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803348200 · Cited by 147

The Complexes of Mammalian Target of Rapamycin

Zhou, H., & Huang, S. (2010) · Current Protein and Peptide Science · doi:10.2174/138920310791824093 · Cited by 153

Positioning mitochondrial plasticity within cellular signaling cascades

Soubannier, V., & McBride, H. M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.07.008 · Cited by 146

mTORC1 signaling: what we still don't know

Wang, X., & Proud, C. G. (2010) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq038 · Cited by 150

Large FK506-binding proteins shape the pharmacology of rapamycin

März, A. M., Fabian, A.-K., Kozany, C., Bracher, A., & Hausch, F. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00678-12 · Cited by 141

Roles of mTOR Signaling in Tissue Regeneration

Wei, X., Luo, L., & Chen, J.-Z. (2019) · Cells · doi:10.3390/cells8091075 · Cited by 136

The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner

Patursky-Polischuk, I., Stolovich-Rain, M., Hausner-Hanochi, M., Kasir, J., Cybulski, N., Avruch, J., Rüegg, M. A., Hall, M. N., & Meyuhas, O. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00980-08 · Cited by 139

Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding

Sami, A., & Karsy, M. J. (2013) · Tumor Biology · doi:10.1007/s13277-013-0800-5 · Cited by 137

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

Yoon, M., Sun, Y., Arauz, E. J., Jiang, Y., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.262816 · Cited by 138

Inhibition of the Insulin-like Growth Factor-1 Receptor (IGF1R) Tyrosine Kinase as a Novel Cancer Therapy Approach

Li, R., Pourpak, A., & Morris, S. W. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm9002395 · Cited by 136

Hold Me Tight

Willis, M. S., & Patterson, C. (2010) · Circulation · doi:10.1161/circulationaha.110.942250 · Cited by 134

FK506-Binding Proteins and Their Diverse Functions

Tong, M., & Jiang, Y. (2015) · Current Molecular Pharmacology · doi:10.2174/1874467208666150519113541 · Cited by 135

Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

Li, M., Zhao, L., Liu, J., Liu, A., Jia, C., Ma, D., Jiang, Y., & Bai, X. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.05.015 · Cited by 132

Inhibition of Human T-Cell Proliferation by Mammalian Target of Rapamycin (mTOR) Antagonists Requires Noncoding RNA Growth-Arrest-Specific Transcript 5 (GAS5)

Mourtada‐Maarabouni, M., Hasan, A. M., Farzaneh, F., & Williams, G. T. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064055 · Cited by 128

Chapter 3 Ribosomal Protein S6 Kinase

Meyuhas, O., & Dreazen, A. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)90003-5 · Cited by 131

mTOR, Cancer and Transplantation

Geissler, E. K., Schlitt, H. J., & Thomas, G. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02391.x · Cited by 122

HijAkt

Dunn, E. F., & Connor, J. H. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396456-4.00002-x · Cited by 124

The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

Blair, L. J., Baker, J. D., Sabbagh, J. J., & Dickey, C. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13033 · Cited by 120

Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies

Garcia, J. A., & Danielpour, D. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2408 · Cited by 120

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment

Martelli, A. M., Chiarini, F., Evangelisti, C., Cappellini, A., Buontempo, F., Bressanin, D., Fini, M., & McCubrey, J. A. (2012) · Oncotarget · doi:10.18632/oncotarget.477 · Cited by 122

Expression and Maintenance of Mitochondrial DNA

Shadel, G. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071163 · Cited by 122

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

Chong, Z. Z., Shang, Y. C., Wang, S., & Maiese, K. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.08.001 · Cited by 119

Key factors in mTOR regulation

Bai, X., & Jiang, Y. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0163-7 · Cited by 123

BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation

da Silva Rosa, S. C., Martens, M. D., Field, J. T., Nguyen, L., Kereliuk, S. M., Hai, Y., Chapman, D., Diehl-Jones, W., Aliani, M., West, A. R., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1821548 · Cited by 117

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic eventsPreprint

Nardella, C., Chen, Z., Salmena, L., Carracedo, A., Alimonti, A., Egia, A., Carver, B., Gerald, W., Cordon-Cardo, C., & Pandolfi, P. P. (2008) · Genes & Development · doi:10.1101/gad.1699608 · Cited by 121

Eukaryotic translation initiation factors as promising targets in cancer therapy

Hao, P., Yu, J., Ward, R. J., Liu, Y., Qiao, H., An, S., & Xu, T. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00607-9 · Cited by 127

Molecular glues and bifunctional compounds: Therapeutic modalities based on induced proximity

Schreiber, S. L. (2024) · Cell Chemical Biology · doi:10.1016/j.chembiol.2024.05.004 · Cited by 112

Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism

Liao, X., Majithia, A. R., Huang, X., & Kimmel, A. R. (2008) · Amino Acids · doi:10.1007/s00726-008-0100-3 · Cited by 112

Mechanisms of amino acid sensing in mTOR signaling pathway

Kim, E. (2009) · Nutrition Research and Practice · doi:10.4162/nrp.2009.3.1.64 · Cited by 104

Lifespan-Extending Effects of Royal Jelly and Its Related Substances on the Nematode Caenorhabditis elegans

Honda, Y., Fujita, Y., Maruyama, H., Araki, Y., Ichihara, K., Sato, A., Kojima, T., Tanaka, M., Nozawa, Y., Ito, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023527 · Cited by 109

Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies

Chapuis, N., Tamburini, J., Green, A. S., Willems, L., Bardet, V., Park, S., Lacombe, C., Mayeux, P., & Bouscary, D. (2010) · Leukemia · doi:10.1038/leu.2010.170 · Cited by 109

Regulation of protein synthesis by amino acids in muscle of neonates

Suryawan, A. (2010) · Frontiers in bioscience · doi:10.2741/3798 · Cited by 98

FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention

Annett, S., Moore, G., & Robson, T. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107623 · Cited by 104

Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin

Xu, J., Pham, C. G., Albanese, S. K., Dong, Y., Oyama, T., Lee, C., Rodrik-Outmezguine, V. S., Yao, Z., Han, S. I., Chen, D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86120 · Cited by 100

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

Uhlenbrock, K., Weiwad, M., Wetzker, R., Fischer, G. S., Wittinghofer, A., & Rubio, I. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.02.015 · Cited by 47

The Switch I Region of Rheb Is Critical for Its Interaction with FKBP38

Ma, D., Bai, X., Guo, S., & Jiang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802356200 · Cited by 56

Regulating the Regulators

Ray, L. B. (2007) · Science s STKE · doi:10.1126/stke.4122007tw418 · Cited by 1

Molecular Mechanisms of Rheb's Regulation of Apoptosis by FKBP38

Zhang, T. (2011) · Journal of Henan University

Rheb GTPase Controls Apoptosis by Regulating Interaction of FKBP38 with Bcl-2 and Bcl-XL

Ma, D., Bai, X., Zou, H., Lai, Y., & Jiang, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092353 · Cited by 48