Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., & Thomas, G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00220-x · Cited by 1,043

Rheb Binds and Regulates the mTOR Kinase

Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., & Avruch, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.053 · Cited by 1,005

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., & Pan, D. (2003) · Nature Cell Biology · doi:10.1038/ncb999 · Cited by 924

The expanding TOR signaling network

Martin, D. E., & Hall, M. N. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.008 · Cited by 496

Rheb fills a GAP between TSC and TOR

Manning, B. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.09.003 · Cited by 483

Importance of tuberin in carcinogenesis

Jin, M., An, Q., & Wang, L. (2017) · Oncology Letters · doi:10.3892/ol.2017.6490 · Cited by 6

NMR analysis of the backbone dynamics of the small GTP ase Rheb and its interaction with the regulatory protein FKBP 38

Cicco, M. D., Kiss, L., & Dames, S. A. (2017) · FEBS Letters · doi:10.1002/1873-3468.12925 · Cited by 6

Direct Interaction between Ras Homolog Enriched in Brain and FK506 Binding Protein 38 in Cashmere Goat Fetal Fibroblast Cells

Wang, X., Wang, Y., Zheng, X., Hao, X., Liang, Y., Wu, M., Wang, X., & Wang, Z. (2014) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2014.14145 · Cited by 6

Potential of mTOR inhibitors as therapeutic agents in hematological malignancies

Sankhala, K. K., & Giles, F. J. (2009) · Expert Review of Hematology · doi:10.1586/ehm.09.31 · Cited by 6

Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions

Tang, C., & Dong, Z. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00012-0 · Cited by 5

Spine morphogenesis and synapse formation in tubular sclerosis complex models

Shimada, T., & Yamagata, K. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1019343 · Cited by 7

Silencing FKBP38 gene by siRNA induces activation of mTOR signaling in goat fetal fibroblasts

Fu, Y., Zheng, X., He, Q., Jia, X., Guo, Z., Yao, R., Wang, Y. F., & Wang, Z. G. (2015) · Genetics and Molecular Research · doi:10.4238/2015.august.14.30 · Cited by 5

Target of rapamycin FATC domain as a general membrane anchor: The FKBP‐12 like domain of FKBP38 as a case study

Cicco, M. D., Milroy, L. G., & Dames, S. A. (2017) · Protein Science · doi:10.1002/pro.3321 · Cited by 6

Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice

Shan, L., Liao, X., Yang, X., Zhu, E., Yuan, H., Zhou, J., Li, X., & Wang, B. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101209 · Cited by 4

Investigating the shared genetic architecture between breast and ovarian cancers

Shi, X., Bu, A., Yang, Y., Wang, Y., Zhao, C., Fan, J., Yang, C., & Jia, X. (2024) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2023-0181 · Cited by 5

Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases

Daneri-Becerra, C., Ciucci, S. M., Mazaira, G. I., & Galigniana, M. D. (2021) · Current Drug Targets · doi:10.2174/1389450121999201230204320 · Cited by 5

Evaluation of mTOR function by a gain-of-function approach

Ohne, Y., Takahara, T., & Maeda, T. (2009) · Cell Cycle · doi:10.4161/cc.8.4.7660 · Cited by 4

Downhill running induced mitophagy in rat soleus muscle via the AMPK pathway

Shang, H., Ma, R.-G., Chen, S.-J., Deng, H., Li, M., Zheng, S.-Q., Zhang, H., Zhang, D., Yang, T., Yang, Y. N., et al. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01093-8 · Cited by 3

Molecular Characterization and Tissue-specific Expression of a Novel FKBP38 Gene in the Cashmere Goat (Capra hircus)

Zheng, X., Hao, X. Y., Chen, Y., Zhang, X., Yang, J., Wang, Z. G., & Liu, D. J. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2011.11398 · Cited by 3

Functions of the Hsp90-Binding FKBP Immunophilins

Ortiz, N. R., Guy, N. C., Garcia, Y. A., Sivils, J. C., Galigniana, M. D., & Cox, M. B. (2022) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-14740-1_2 · Cited by 3

An Injectable Sustained Release Hydrogel of Hyaluronic Acid Loaded with β‐Ecdysterone Ameliorates Cartilage Damage in Osteoarthritis via Activating Autophagy

Tang, Y., Zhou, K., Mo, Y., Xin, D., Xiong, Z., & Yu, X. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300101 · Cited by 3

New Agents and Approaches for Targeting the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR Cell Survival Pathways

McCubrey, J. A., Steelman, L. S., Chappell, W. H., Abrams, S. L., Franklin, R. A., Montalto, G., Cervello, M., Nicoletti, F., Malaponte, G., Massarino, C., et al. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5847-0_13 · Cited by 3

EDITORIAL: Inhibition of PI3K/Akt/mTOR Signaling by Natural Products

Huang, S. (2013) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990085 · Cited by 3

Host Cell-dependent Modulatory Role of Ras Homolog Enriched in Brain-Like-1 (RhebL1) Protein in Influenza A/NWS/33 Virus-infected Mammalian Cells

Buttrini, M., & Conto, F. D. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2903116 · Cited by 2

FKBP38 deletion exacerbates ConA-induced hepatitis by promoting the immune response through the MCP-1/p38 pathway

Wang, S., Xiao, G., Tang, M., Bi, X., Xing, C., Liu, A., Zhao, A. Z., & Li, F. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112659 · Cited by 2

Sequence-Selective Molecular Recognition of the C-Terminal CaaX-Boxes of Rheb and Related Ras-Proteins by Synthetic Receptors

Düppe, P. M., Phuong, T. T. T., Autzen, J., Schöpel, M., Yip, K. T., Stoll, R., & Scherkenbeck, J. (2014) · ACS Chemical Biology · doi:10.1021/cb5002075 · Cited by 2

Role of Mammalian Target of Rapamycin (mTOR) in Cardiac Homeostasis in Metabolic Disorders

Liu, X., & Ren, J. T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00027-x · Cited by 2

In vitro mTORC1 Kinase Assay for Mammalian Cells Protocol

Dodd, K. M., & Tee, A. R. (2016) · BIO-PROTOCOL · doi:10.21769/bioprotoc.1827 · Cited by 2

Structure and Function of the mTOR Activator Rheb

Marshall, C. B., Mazhab‐Jafari, M. T., Stambolic, V., & Ikura, M. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1806-1_13 · Cited by 2

FKBP38 Regulates Self-Renewal and Survival of GBM Neurospheres

Dowling, A., Walbridge, S., Ertekin, C., Namagiri, S., Camacho, K., Chowdhury, A. K., Bryant, J.-P., Kohut, E., Heiss, J. D., Brown, D. A., et al. (2023) · Cells · doi:10.3390/cells12212562 · Cited by 2

The Role of Target of Rapamycin Signaling in Tuberous Sclerosis Complex

Manning, B. D. (2010) · Wiley eBooks · doi:10.1002/9783527630073.ch6 · Cited by 2

Modeling Tuberous Sclerosis Complex: Brain Development and Hyperexcitability

Ess, K. C. (2009) · Neuromethods · doi:10.1007/978-1-60327-263-6_5 · Cited by 2

FKBP (FK506 Binding Protein)

D’Arrigo, P., Tufano, M., Rea, A., Romano, S., & Romano, M. F. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101769-1 · Cited by 2

The Regulation of Mammalian Target of Rapamycin

Xie, J. (2012) · Figshare · Cited by 2

SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts

He, Q., Wang, Y., Zhao, K., Binderiya, U., Bao, L., Zhao, P., Yan, D., Hao, H., Guo, X., & Wang, Z. (2018) · Journal of Applied Animal Research · doi:10.1080/09712119.2018.1495643 · Cited by 1

The sulfonamide anticancer agent indisulam enhances the chemosensitivity of gastric cancer cells by targeting FKBP8

Li, Y., Lu, C., Lu, J., Jiang, H., Li, D., Wang, Y., Xu, G., Wang, X., & Ma, J. (2026) · FEBS Journal · doi:10.1111/febs.70494 · Cited by 1

Amino Acid Regulation of hVps34 and mTORC1 Signaling

(2010) · The Enzymes · doi:10.1016/s1874-6047(10)27006-3 · Cited by 1

mTORC1: A Signaling Integration Node Involved in Cell Growth

Kubica, N., & Blenis, J. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-271-1_1 · Cited by 1

Translation Control and Insulin Signaling

Selvaraj, A., & Thomas, G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00275-8 · Cited by 1

Multiple outcomes for PI3K/Akt/mTOR targeting in non-Hodgkin lymphoma

Müller, A. (2015) · edoc Publication server (Humboldt University of Berlin) · doi:10.18452/17284 · Cited by 1

Hormonal and Nutrient Signalling to Protein Kinase B and Mammalian Target of Rapamycin in Pancreatic Beta-Cells

Mostafa, N. M. E.-S. B. E.-D. (2012) · Figshare · Cited by 1

CHARACTERIZING AND TREATING THE NEUROPATHOLOGY OF TUBEROUS SCLEROSIS COMPLEX IN THE MOUSE

Way, S. W. (2010) · Digital Commons-TMC (Texas Medical Center)

Mitochondria, a Platform for Diverse Signaling Pathways

Schauss, A. C., & McBridee, H. M. (2009) · Springer eBooks · doi:10.1007/978-3-642-02112-1_11

Regulation of autophagy and mTOR during Semliki Forest virus infection

Eng, K. E. (2012) · Figshare

Characterization of Drosophila Lnk

Werz, C. (2009) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-006073429

Targeting the mTOR Pathway for Tumor Therapeutics

Chen, W. (2009) · Wiley eBooks · doi:10.1002/9780470538951.ch22

Regulation of TOR Complex 1 by Amino Acids Through Small GTPases

(2010) · The Enzymes · doi:10.1016/s1874-6047(10)27004-x

Analyse fonctionnelle de la traduction dépendante de la coiffe m⁷GTP en réponse à la fécondation et au cours du cycle cellulaire de l'embryon d'oursin

Oulhen, N. (2008) · HAL

mTOR inhibition as a therapeutic strategy in tuberous sclerosis or sporadic lymphangioleiomyomatosis

Davies, D. M. (2011) · ORCA Online Research @Cardiff (Cardiff University)

Genòmica evolutiva de la via de transducció de senyal de la insulina/TOR a insectes i vertebrats.

Ponce, D. Á. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Implicit methods for modeling gene regulatory networks

Garg, A. D. (2009) · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · doi:10.5075/epfl-thesis-4474

Basic Science for Clinicians Hold Me Tight Role of the Heat Shock Protein Family of Chaperones in Cardiac Disease

Willis, M. S., & Patterson, P. C. (2016)

Mammalian m-AAA Proteases as Key Regulators of Mitochondrial Function - Analysis of Dominant Negative Mutant Variants

Raschke, I. (2009) · Kölner Universitäts PublikationsServer (Universität zu Köln)

Selected genes involved in GIST evolution from indolent to advanced tumours

Quattrone, A. (2015)

mTOR regulates Aurora A via enhancing protein stability

Li, F. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1876

IMPLICATIONS OF MITOTIC ONSET REGULATION IN TUBEROUS SCLEROSIS

Dare-Shih, J. (2016) · Scholarship at UWindsor (University of Windsor)

Analysis of signal pathway protein-protein interactions during biotic and abiotic stress.

Malone, J. M. (2009) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)

Regulation of mRNA translation in renal physiology and

Kasinath, B. S., Féliers, D., Sataranatarajan, K., Choudhury, G. G., Lee, M. J., & Mariappan, M. M. (2009)

Unselective Disposal of Cellular Aggregates

Seneci, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800186-8.00004-3

The role of glutamine in the regulation of mTOR signalling in pancreatic β-cells

Alghanim, G. (2017) · Leicester Research Archive (University of Leicester)

Type 2B von Hippel-Lindau disease: molecular biology, tumor growth, and development

Lee, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/29tv-bb60

An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells

Kjellman, M. (2020) · UTUPub (University of Turku)

Tetrandrine modulates SQSTM1-mediated selective autophagy and protects pulmonary fibrosisPreprint

Liu, Y., Zhong, W., Zhang, J., Chen, W., Lu, Y., Qiao, Y., Zeng, Z., Huang, H., Zou, F., Meng, X., et al. (2021) · doi:10.22541/au.161185451.12306983/v1

Key factors in mTOR regulation

Jiang, X. B. (2010)

Fission Yeast Model Study for Dissection of TSC Pathway

Matsumoto, T. (2010) · doi:10.21236/ada560751

Functional Dissection of FKBP38 in the Biogenesis of Cystic Fibrosis Transmembrane Conductance Regulator in the Endoplasmic Reticulum

Banasavadi‐Siddegowda, Y. (2011) · OhioLink ETD Center (Ohio Library and Information Network)

FKBP (FK506 Binding Protein)

D’Arrigo, P., Tufano, M., Rea, A., Romano, S., & Romano, M. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101769

References

(2013) · Elsevier eBooks · doi:10.1016/b978-0-12-388425-1.00023-3

RHEB

Shimada, T., Sugiura, H., & Yamagata, K. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101555-1

RHEB

Shimada, T., Sugiura, H., & Yamagata, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101555

Dietary Protein Re-Alimentation Following Restriction Improves Protein Deposition Via Changing Amino Acid Metabolism and Transcriptional Profiling of Muscle Tissue in Growing Beef CattlePreprint

Wang, J., Shen, C., Zhao, G., Hanigan, M. D., & Li, M. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4612882

Inhibitors of CK2 Kinase for the Treatment of Gliomas and Other Brain Tumors

Pucko, E. B., & Ostrowski, R. P. (2024) · Acta Poloniae Pharmaceutica - Drug Research · doi:10.32383/appdr/183629

Omics research in lymphangioleiomyomatosis: status and challenges

Zhang, X., Liu, S., Yang, L., Cheng, C., Wang, H., Hu, D., Zhang, X., Zhang, M., Liu, Y., Tian, X., et al. (2024) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2024.2403498

Resistance Exercise and Alcohol: Combined Effects on Physiology and Performance

Levitt, D. E. (2018) · University of North Texas Digital Library (University of North Texas) · doi:10.12794/metadc1248374

FKBP38 Alleviates Osteoarthritis Progression by Inhibiting Chondrocyte Senescence

Wu, J., Chen, W., Zou, Z., Li, H., Zhou, T., Liao, Z., Rao, Z., Li, K., Tan, X., Cao, H., et al. (2025) · Cartilage · doi:10.1177/19476035251377525

Adaptations environnementales de la protéosynthèse et de la protéolyse dans le muscle de poulet : voies de signalisation impliquées

Ezzine, S. B.-O. (2011) · theses.fr (ABES) · doi:10.70675/ac9c76d9z37b4z44f6z8ba3zf8ac28779458

Coordination par l'horloge circadienne de l'activation rythmique du stress du RE et de la traduction dans le foie de souris

Cretenet, G. (2010) · theses.fr (ABES) · doi:10.70675/9d4c5041z0b9ez46e5zae69z1fddb5a9cd42

Role of p27/Kip1 in auphagy under metabolic stress conditions

Nowosad, A. (2018) · theses.fr (ABES) · doi:10.70675/11eb36d1zc3baz4d74z8d00zc049667c5976

Biochemical characterization of mTORC1 regulation by glutamine metabolism

Bodineau, C. (2020) · theses.fr (ABES) · doi:10.70675/9d5aaabdz81bdz4118zb3edze237bdd8dee0

Compréhension des étapes précoces de la résistance adaptative aux inhibiteurs de tyrosine kinase de l'EGFR dans les cancers bronchiques

Figarol, S. (2020) · theses.fr (ABES) · doi:10.70675/9b097a88z7be2z4f00z913fze60d534fa601

Conséquence de l’activation chronique de la signalisation TGFβ sur le métabolisme musculaire au cours de l’atrophie

Chauvet, V. (2023) · theses.fr (ABES) · doi:10.70675/6873c53ezec0dz4bf2z82a9z2cc1c133bb5a

FKBP8 connects the Hsp70-Hsp90 chaperone machinery to the folding of membrane proteins

Ge, M.-X., Wu, M.-Z., Jia, J. H., Li, Z.-P., Bai, Z., He, J., Chuh, J., Zhang, Y., Li, J., & Zhang, Z.-R. (2026) · Nature Communications · doi:10.1038/s41467-026-74519-6

MCOLN2 (Mucolipin-2) promotes autophagy to confer Adriamycin resistance in breast cancer by regulating mTOR degradation

Yu, H., Wang, J., Ji, Y., Liu, X., Xie, M., Lo, C. Y., Cao, W., Zhou, H., Li, X., Huang, X., et al. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01270-x

Multi-omics analysis reveals the effects of Codonopsis pilosula polysaccharides on the skeletal muscle development of Sansui ducks during the embryonic stage

Liu, A., Rao, Y., Yue, Y., Zhu, J., Wen, J., Yao, B., Zhu, Y., Boonanuntan, S., & Yang, S. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107595

BindingDB Entry 50038898: Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.

BindingDB (2012) · UC San Diego · doi:10.7270/q2p84ctd

The effect of age, sex, and end-stage heart failure on the human cardiac transcriptome

Stefani, M. (2014) · The Sydney eScholarship Repository (The University of Sydney)

Molecular studies of intra-oocyte phosphatidylinositol 3 kinase (PI3K) signaling pathway in controlling female fertility

Venu, D., & Reddy, P. (2009)

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

Uhlenbrock, K., Weiwad, M., Wetzker, R., Fischer, G. S., Wittinghofer, A., & Rubio, I. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.02.015 · Cited by 47

The Switch I Region of Rheb Is Critical for Its Interaction with FKBP38

Ma, D., Bai, X., Guo, S., & Jiang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802356200 · Cited by 56

Regulating the Regulators

Ray, L. B. (2007) · Science s STKE · doi:10.1126/stke.4122007tw418 · Cited by 1

Molecular Mechanisms of Rheb's Regulation of Apoptosis by FKBP38

Zhang, T. (2011) · Journal of Henan University

Rheb GTPase Controls Apoptosis by Regulating Interaction of FKBP38 with Bcl-2 and Bcl-XL

Ma, D., Bai, X., Zou, H., Lai, Y., & Jiang, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092353 · Cited by 48