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Polymorphic Y Chromosomes Harbor Cryptic Variation with Manifold Functional Consequences
Abstract
The paucity of polymorphisms in single-copy genes on the Y chromosome of Drosophila contrasts with data indicating that this chromosome has polymorphic phenotypic effects on sex ratio, temperature sensitivity, behavior, and fitness. We show that the Y chromosome of D. melanogaster harbors substantial genetic diversity in the form of polymorphisms for genetic elements that differentially affect the expression of hundreds of X-linked and autosomal genes. The affected genes are more highly expressed in males, more meagerly expressed in females, and more highly divergent between species. Functionally, they affect microtubule stability, lipid and mitochondrial metabolism, and the thermal sensitivity of spermatogenesis. Our findings provide a mechanism for adaptive phenotypic variation associated with the Y chromosome.
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Cites
Transposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
Cited by
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration
Bachtrog, D. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3366 · Cited by 854
Deans, C., & Maggert, K. A. (2015) · Genetics · doi:10.1534/genetics.114.173492 · Cited by 554
Forsberg, L. A., Rasi, C., Malmqvist, N., Davies, H., Pasupulati, S., Pakalapati, G., Sandgren, J., de Ståhl, T. D., Zaghlool, A., Giedraitis, V., et al. (2014) · Nature Genetics · doi:10.1038/ng.2966 · Cited by 458
The Evolution of Sex Determination
Beukeboom, L. W., & Perrin, N. (2014) · doi:10.1093/acprof:oso/9780199657148.001.0001 · Cited by 411
The evolutionary causes and consequences of sex-biased gene expression
Parsch, J., & Ellegren, H. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3376 · Cited by 368
Metadata
- Authors
- Lemos, B., Araripe, L. O., & Hartl, D. L.
- Venue
- Science
- Published
- 2008-01-04
- Volume
- 319
- Issue
- 5859
- Pages
- 91-93
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004000260
- Cited by
- 249
- References
- 1
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- closed
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