What do you mean, “epigenetic
Open accessAbstract
Interest in the field of epigenetics has increased rapidly over the last decade, with the term becoming more identifiable in biomedical research, scientific fields outside of the molecular sciences, such as ecology and physiology, and even mainstream culture. It has become increasingly clear, however, that different investigators ascribe different definitions to the term. Some employ epigenetics to explain changes in gene expression, others use it to refer to transgenerational effects and/or inherited expression states. This disagreement on a clear definition has made communication difficult, synthesis of epigenetic research across fields nearly impossible, and has in many ways biased methodologies and interpretations. This article discusses the history behind the multitude of definitions that have been employed since the conception of epigenetics, analyzes the components of these definitions, and offers solutions for clarifying the field and mitigating the problems that have arisen due to these definitional ambiguities.
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Ambiguous definitions of inter- versus trans-generational effects have led to misunderstandings and bias in methodologies and interpretations, especially in interdisciplinary research.
“This has led to misunderstandings as well as to bias in methodologies and interpretations, especially in interdisciplinary research (253).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [253]
The Abstract says differing definitions of “epigenetics” have made communication and cross-field synthesis difficult and have biased methodologies and interpretations. It does not specifically attribute those consequences to ambiguous definitions of inter- versus trans-generational effects. Page numbers are not supplied in our copy. (LLM, conf=0.84)
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- Authors
- Deans, C., & Maggert, K. A.
- Affiliations
- Texas A&M University (US)
- Corresponding author
- Deans, Carrie
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-01
- Volume
- 199
- Issue
- 4
- Pages
- 887-896
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- PMC
- PMC4391566
- OpenAlex
- W2139232339
- Cited by
- 554
- References
- 126
- Citations by year
- 2026: 30 · 2025: 55 · 2024: 49 · 2023: 56 · 2022: 77 · 2021: 60 · 2020: 79 · 2019: 49 · 2018: 43 · 2017: 24 · 2016: 21 · 2015: 10 · 2014: 1
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- epigenetics, gene expression, transgenerational inheritance, epigenetic inheritance, history of epigenetics, definitional ambiguity
- MeSH terms
- Animals, Humans, Terminology as Topic, Epigenesis, Genetic, Epigenomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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