The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of Replication Fork Progression Through Histone Supply and Demand
Open accessAbstract
DNA replication in eukaryotes requires nucleosome disruption ahead of the replication fork and reassembly behind. An unresolved issue concerns how histone dynamics are coordinated with fork progression to maintain chromosomal stability. Here, we characterize a complex in which the human histone chaperone Asf1 and MCM2–7, the putative replicative helicase, are connected through a histone H3-H4 bridge. Depletion of Asf1 by RNA interference impedes DNA unwinding at replication sites, and similar defects arise from overproduction of new histone H3-H4 that compromises Asf1 function. These data link Asf1 chaperone function, histone supply, and replicative unwinding of DNA in chromatin. We propose that Asf1, as a histone acceptor and donor, handles parental and new histones at the replication fork via an Asf1–(H3-H4)–MCM2–7 intermediate and thus provides a means to fine-tune replication fork progression and histone supply and demand.
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Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes & Development · doi:10.1101/gad.1301205 · Cited by 767
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Kinner, A., Wu, W., Staudt, C., & Iliakis, G. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn550 · Cited by 1,256
Acetylation of Histone H3 Lysine 56 Regulates Replication-Coupled Nucleosome Assembly
Li, Q., Zhou, H., Wurtele, H., Davies, B., Horazdovsky, B., Verreault, A., & Zhang, Z. (2008) · Cell · doi:10.1016/j.cell.2008.06.018 · Cited by 447
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
O'Sullivan, R. J., Kubicek, S., Schreiber, S. L., & Karlseder, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1897 · Cited by 416
Alabert, C., Bukowski-Wills, J.-C., Lee, S.-B., Kustatscher, G., Nakamura, K., de Lima Alves, F., Menard, P., Mejlvang, J., Rappsilber, J., & Groth, A. (2014) · Nature Cell Biology · doi:10.1038/ncb2918 · Cited by 353
Self-citationChaperoning Histones during DNA Replication and Repair
Ransom, M., Dennehey, B. K., & Tyler, J. K. (2010) · Cell · doi:10.1016/j.cell.2010.01.004 · Cited by 344
Metadata
- Authors
- Groth, A., Corpet, A., Cook, A. J. L., Roche, D., Bartek, J., Lukas, J., & Almouzni, G.
- Venue
- Science
- Published
- 2007-12-21
- Volume
- 318
- Issue
- 5858
- Pages
- 1928-1931
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970304959
- Cited by
- 483
- References
- 1
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Groth, A., Corpet, A., Cook, A. J. L., Roche, D., Bartek, J., Lukas, J., & Almouzni, G. (2007). Regulation of Replication Fork Progression Through Histone Supply and Demand. Science. https://doi.org/10.1126/science.1148992
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