The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Widespread Genetic Incompatibility in C. Elegans Maintained by Balancing Selection
Open accessAbstract
Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel-1 arrest if their sperm parent carries an incompatible allele of a second, paternal-effect locus, peel-1 . The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PAML: a program package for phylogenetic analysis by maximum likelihood
Yang, Z. (1997) · Bioinformatics · doi:10.1093/bioinformatics/13.5.555 · Cited by 5,373
VISTA: computational tools for comparative genomics
Frazer, K. A., Pachter, L., Poliakov, A., Rubin, E. M., & Dubchak, I. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh458 · Cited by 2,798
Balancing Selection and Its Effects on Sequences in Nearby Genome Regions
Charlesworth, D. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020064 · Cited by 717
Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map
Wicks, S. R., Yeh, R. T., Gish, W. R., Waterston, R. H., & Plasterk, R. H. A. (2001) · Nature Genetics · doi:10.1038/88878 · Cited by 648
High-Throughput Gene Mapping in Caenorhabditis elegans
Swan, K. A., Curtis, D. E., McKusick, K. B., Voinov, A. V., Mapa, F. A., & Cancilla, M. R. (2002) · Genome Research · doi:10.1101/gr.208902 · Cited by 616
Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis
Stahl, E. A., Dwyer, G., Mauricio, R., Kreitman, M., & Bergelson, J. (1999) · Nature · doi:10.1038/23260 · Cited by 600
Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegans
Reinke, V., Gil, I. S., Ward, S., & Kazmer, K. (2004) · Development · doi:10.1242/dev.00914 · Cited by 452
The role of selfish genetic elements in eukaryotic evolution
Hurst, G. D. D., & Werren, J. H. (2001) · Nature Reviews Genetics · doi:10.1038/35084545 · Cited by 427
Natural Variation and Copulatory Plug Formation in Caenorhabditis elegans
Hodgkin, J., & Doniach, T. (1997) · Genetics · doi:10.1093/genetics/146.1.149 · Cited by 376
High Local Genetic Diversity and Low Outcrossing Rate in Caenorhabditis elegans Natural Populations
Barrière, A., & Félix, M.-A. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.022 · Cited by 363
Cited by
The genetic causes of convergent evolution
Stern, D. L. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3483 · Cited by 818
The natural history of Caenorhabditis elegans
Félix, M.-A., & Braendle, C. (2010) · Current Biology · doi:10.1016/j.cub.2010.09.050 · Cited by 458
The Natural Biotic Environment of Caenorhabditis elegans
Schulenburg, H., & Félix, M.-A. (2017) · Genetics · doi:10.1534/genetics.116.195511 · Cited by 437
Molecular mechanisms of epistasis within and between genes
Lehner, B. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.05.007 · Cited by 326
Chae, E., Bomblies, K., Kim, S.-T., Karelina, D., Zaidem, M., Ossowski, S., Martín-Pizarro, C., Laitinen, R. A. E., Rowan, B. A., Tenenboim, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.049 · Cited by 281
Metadata
- Authors
- Seidel, H. S., Rockman, M. V., & Kruglyak, L.
- Venue
- Science
- Published
- 2008-02
- Volume
- 319
- Issue
- 5863
- Pages
- 589-594
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964128403
- Cited by
- 280
- References
- 28
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Widespread Genetic Incompatibility in C. Elegans Maintained by Balancing Selection. https://app.cochat.ai/papers/10.1126/science.1151107
- The paper
- Seidel, H. S., Rockman, M. V., & Kruglyak, L. (2008). Widespread Genetic Incompatibility in C. Elegans Maintained by Balancing Selection. Science. https://doi.org/10.1126/science.1151107
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
