The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hepatic Glucose Sensing via the CREB Coactivator CRTC2
Abstract
Chronic hyperglycemia contributes to the development of diabetes-associated complications. Increases in the concentration of circulating glucose activate the hexosamine biosynthetic pathway (HBP) and promote the O-glycosylation of proteins by O-glycosyl transferase (OGT). We show that OGT triggered hepatic gluconeogenesis through the O-glycosylation of the transducer of regulated cyclic adenosine monophosphate response element–binding protein (CREB) 2 (TORC2 or CRTC2). CRTC2 was O-glycosylated at sites that normally sequester CRTC2 in the cytoplasm through a phosphorylation-dependent mechanism. Decreasing amounts of O-glycosylated CRTC2 by expression of the deglycosylating enzyme O-GlcNAcase blocked effects of glucose on gluconeogenesis, demonstrating the importance of the HBP in the development of glucose intolerance.
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Cites
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4
Kim, J. K., Zisman, A., Fillmore, J. J., Peroni, O. D., Kotani, K., Perret, P., Zong, H., Dong, J., Kahn, C. R., Kahn, B. B., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10294 · Cited by 202
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Regulation of glucose metabolism from a liver-centric perspective
Han, H.-S., Kang, G., Kim, J. S., Choi, B. H., & Koo, S.-H. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.122 · Cited by 835
Metabolic reprogramming and epigenetic modifications on the path to cancer
Sun, L., Zhang, H., & Gao, P. (2022) · Protein & Cell · doi:10.1007/s13238-021-00846-7 · Cited by 770
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism
Yi, W., Clark, P. M., Mason, D. E., Keenan, M. C., Hill, C., Goddard, W. A., Peters, E. C., Driggers, E. M., & Hsieh-Wilson, L. C. (2012) · Science · doi:10.1126/science.1222278 · Cited by 676
Insulin regulation of gluconeogenesis
Hatting, M., Tavares, C. D. J., Sharabi, K., Rines, A. K., & Puigserver, P. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13435 · Cited by 587
Metadata
- Authors
- Dentin, R., Hedrick, S., Xie, J., Yates, J., & Montminy, M.
- Venue
- Science
- Published
- 2008-03-07
- Volume
- 319
- Issue
- 5868
- Pages
- 1402-1405
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067729127
- Cited by
- 319
- References
- 1
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dentin, R., Hedrick, S., Xie, J., Yates, J., & Montminy, M. (2008). Hepatic Glucose Sensing via the CREB Coactivator CRTC2. Science. https://doi.org/10.1126/science.1151363
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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