The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism
Open accessAbstract
Metabolic Sensor: The enzyme O-GlcNAc transferase (OGT) catalyzes the transfer of N -acetylglucosamine from uridine diphospho- N -acetylglucosamine (UDP-GlcNAc) to serine or threonine residues of intracellular proteins and responds to the metabolic status of the cell. Yi et al. (p. 975 ; see the Perspective by Mattaini and Vander Heiden ) show that O-GlcNAcylation of phosphofructokinase 1 (PFK1) reduces its activity, thus influencing rates of glycolysis within cells. O-GlcNAcylation of PFK1 was increased in cells exposed to hypoxia, and was increased in several cell lines derived from human tumors. Thus, metabolic changes mediated by O-GlcNAcylation may benefit anabolism and growth of cancer cells. However, glycosylation of PFK1 was not detected in rapidly proliferating normal cells.
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Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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Self-citationThe M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
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Ras, PI(3)K and mTOR signalling controls tumour cell growth
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Self-citationCycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins
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Self-citationThe return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis
Xie, N., Tan, Z., Banerjee, S., Cui, H., Ge, J., Liu, R.-M., Bernard, K., Thannickal, V. J., & Liu, G. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0780oc · Cited by 582
Global profiling of lysine reactivity and ligandability in the human proteome
Hacker, S. M., Backus, K. M., Lazear, M. R., Forli, S., Correia, B. E., & Cravatt, B. F. (2017) · Nature Chemistry · doi:10.1038/nchem.2826 · Cited by 485
Tumor glycolysis, an essential sweet tooth of tumor cells
Paul, S., Ghosh, S., & Kumar, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.09.007 · Cited by 449
Metadata
- Authors
- Yi, W., Clark, P. M., Mason, D. E., Keenan, M. C., Hill, C., Goddard, W. A., Peters, E. C., Driggers, E. M., & Hsieh-Wilson, L. C.
- Venue
- Science
- Published
- 2012-08-24
- Volume
- 337
- Issue
- 6097
- Pages
- 975-980
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2137741805
- Cited by
- 676
- References
- 16
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- green
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