The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
High-Resolution Mapping of Crossovers Reveals Extensive Variation in Fine-Scale Recombination Patterns Among Humans
Abstract
Recombination plays a crucial role in meiosis, ensuring the proper segregation of chromosomes. Recent linkage disequilibrium (LD) and sperm-typing studies suggest that recombination rates vary tremendously across the human genome, with most events occurring in narrow “hotspots.” To examine variation in fine-scale recombination patterns among individuals, we used dense, genome-wide single-nucleotide polymorphism data collected in nuclear families to localize crossovers with high spatial resolution. This analysis revealed that overall recombination hotspot usage is similar in males and females, with individual hotspots often active in both sexes. Across the genome, roughly 60% of crossovers occurred in hotspots inferred from LD studies. Notably, however, we found extensive and heritable variation among both males and females in the proportion of crossovers occurring in these hotspots.
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Citations
Cites
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
An evolutionary view of human recombination
Coop, G., & Przeworski, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1947 · Cited by 344
Self-citation
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Ober, C., Loisel, D. A., & Gilad, Y. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2415 · Cited by 787
Self-citationBiased gene conversion and the evolution of mammalian genomic landscapes
Duret, L., & Galtier, N. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082908-150001 · Cited by 737
A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness
O'Connell, J., Gurdasani, D., Delaneau, O., Pirastu, N., Ulivi, S., Cocca, M., Traglia, M., Huang, J., Huffman, J. E., Rudan, I., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004234 · Cited by 593
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Sankararaman, S., Mallick, S., Patterson, N., & Reich, D. (2016) · Current Biology · doi:10.1016/j.cub.2016.03.037 · Cited by 465
Metadata
- Authors
- Coop, G., Wen, X., Ober, C., Pritchard, J. K., & Przeworski, M.
- Venue
- Science
- Published
- 2008-03-07
- Volume
- 319
- Issue
- 5868
- Pages
- 1395-1398
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067706784
- Cited by
- 368
- References
- 2
- FWCI
- 20.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Coop, G., Wen, X., Ober, C., Pritchard, J. K., & Przeworski, M. (2008). High-Resolution Mapping of Crossovers Reveals Extensive Variation in Fine-Scale Recombination Patterns Among Humans. Science. https://doi.org/10.1126/science.1151851
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