The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization
Abstract
Electrostatic interactions with negatively charged membranes contribute to the subcellular targeting of proteins with polybasic clusters or cationic domains. Although the anionic phospholipid phosphatidylserine is comparatively abundant, its contribution to the surface charge of individual cellular membranes is unknown, partly because of the lack of reagents to analyze its distribution in intact cells. We developed a biosensor to study the subcellular distribution of phosphatidylserine and found that it binds the cytosolic leaflets of the plasma membrane, as well as endosomes and lysosomes. The negative charge associated with the presence of phosphatidylserine directed proteins with moderately positive charge to the endocytic pathway. More strongly cationic proteins, normally associated with the plasma membrane, relocalized to endocytic compartments when the plasma membrane surface charge decreased on calcium influx.
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Cites
Plasma membrane phosphoinositide organization by protein electrostatics
McLaughlin, S., & Murray, D. (2005) · Nature · doi:10.1038/nature04398 · Cited by 868
Receptor Activation Alters Inner Surface Potential During Phagocytosis
Yeung, T., Terebiznik, M., Yu, L., Silvius, J., Abidi, W. M., Philips, M., Levine, T., Kapus, A., & Grinstein, S. (2006) · Science · doi:10.1126/science.1129551 · Cited by 329
Self-citation
Cited by
The Distribution and Function of Phosphatidylserine in Cellular Membranes
Leventis, P. A., & Grinstein, S. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.093008.131234 · Cited by 988
Self-citationMicroautophagy of Cytosolic Proteins by Late Endosomes
Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M., & Santambrogio, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.003 · Cited by 902
Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape
Lorent, J. H., Levental, K. R., Ganesan, L., Rivera-Longsworth, G., Sezgin, E., Doktorova, M., Lyman, E., & Levental, I. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0529-6 · Cited by 774
Endocytosis unplugged: Multiple ways to enter the cell
Kumari, S., MG, S., & Mayor, S. (2010) · Cell Research · doi:10.1038/cr.2010.19 · Cited by 599
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
Vance, J. E., & Tasseva, G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.08.016 · Cited by 521
Metadata
- Authors
- Yeung, T., Gilbert, G. E., Shi, J., Silvius, J., Kapus, A., & Grinstein, S.
- Venue
- Science
- Published
- 2008-01-11
- Volume
- 319
- Issue
- 5860
- Pages
- 210-213
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046138985
- Cited by
- 1,107
- References
- 2
- FWCI
- 23.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yeung, T., Gilbert, G. E., Shi, J., Silvius, J., Kapus, A., & Grinstein, S. (2008). Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization. Science. https://doi.org/10.1126/science.1152066
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