MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,791

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Guy, J., Hendrich, B., Holmes, M., Martin, J. E., & Bird, A. (2001) · Nature Genetics · doi:10.1038/85899 · Cited by 1,558

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405

Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232

Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation

Zhou, Z., Hong, E. J., Cohen, S., Zhao, W.-N., Ho, H.-Y. H., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.037 · Cited by 877

Mild overexpression of MeCP2 causes a progressive neurological disorder in mice

Collins, A. L., Levenson, J. M., Vilaythong, A. P., Richman, R., Armstrong, D. L., Noebels, J. L., David Sweatt, J., & Zoghbi, H. Y. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh282 · Cited by 626

The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression

Chang, Q., Khare, G., Dani, V., Nelson, S., & Jaenisch, R. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.027 · Cited by 578

MeCP2 Controls Excitatory Synaptic Strength by Regulating Glutamatergic Synapse Number

Chao, H.-T., Zoghbi, H. Y., & Rosenmund, C. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.018 · Cited by 511

The link between hypothalamic epigenetic modifications and long-term feeding control

Benite‐Ribeiro, S. A., Putt, D. A., Soares-Filho, M. C., & dos Santos, J. M. (2016) · Appetite · doi:10.1016/j.appet.2016.08.111 · Cited by 25

Persistent Unresolved Inflammation in theMecp2-308 Female Mutated Mouse Model of Rett Syndrome

Cortelazzo, A., Felice, C. D., Filippis, B. D., Ricceri, L., Laviola, G., Leoncini, S., Signorini, C., Pescaglini, M., Guerranti, R., Timperio, A. M., et al. (2017) · Mediators of Inflammation · doi:10.1155/2017/9467819 · Cited by 25

Decoding epigenetic codes: new frontiers in exploring recovery from spinal cord injury

Chang, P., Chang, P.-Y., Zhu, Q.-S., Zhu, Q., & Saijilafu (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.276323 · Cited by 25

Hip displacement and scoliosis in Rett syndrome – screening is required

Tay, G. S., GRAHAM, H., Graham, H. K., Leonard, H., Reddihough, D. S., & Baikie, G. (2009) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2009.03359.x · Cited by 25

Genome-Wide Identification of Calcium-Response Factor (CaRF) Binding Sites Predicts a Role in Regulation of Neuronal Signaling Pathways

Pfenning, A. R., Kim, T.-K., Spotts, J. M., Hemberg, M., Su, D., & West, A. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010870 · Cited by 24

Genetic Diseases: Congenital Central Hypoventilation, Rett, and Prader‐Willi Syndromes

Gallego, J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c100037 · Cited by 28

Promoter‐like sequences regulating transcriptional activity in neurexin and neuroligin genes

Runkel, F., Rohlmann, A., Reißner, C., Brand, S., & Missler, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12372 · Cited by 25

MiR-132 Is Upregulated by Ischemic Preconditioning of Cultured Hippocampal Neurons and Protects them from Subsequent OGD Toxicity

Keasey, M. P., Scott, H. L., Bantounas, I., Uney, J. B., & Kelly, S. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0740-9 · Cited by 24

Network Modeling in Biology: Statistical Methods for Gene and Brain Networks

Wang, Y. X. R., Li, L., Li, J. J., & Huang, H. (2020) · Statistical Science · doi:10.1214/20-sts792 · Cited by 28

Emerging physiological and pathological roles of MeCP2 in non-neurological systems

Wang, J., Xiao, Y., Liu, C., Huang, Y., Petersen, R. B., Zheng, L., & Huang, K. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108768 · Cited by 23

MeCP2 and transcriptional control of eukaryotic gene expression

Akhtar, G. B., Buist, M., & Rastegar, M. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151237 · Cited by 24

MeCP2 post‐translational regulation through PEST domains: two novel hypotheses

Thambirajah, A. A., Eubanks, J. H., & Ausió, J. (2009) · BioEssays · doi:10.1002/bies.200800220 · Cited by 24

Identification of two novel Shank3 transcripts in the developing mouse neocortex

Waga, C., Asano, H., Sanagi, T., Suzuki, E., Nakamura, Y., Tsuchiya, A., Itoh, M., Goto, Y., Kohsaka, S., & Uchino, S. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12505 · Cited by 25

Osteoblast function and bone histomorphometry in a murine model of Rett syndrome

Blue, M. E., Boskey, A. L., Doty, S. B., Fedarko, N. S., Hossain, M. A., & Shapiro, J. R. (2015) · Bone · doi:10.1016/j.bone.2015.01.024 · Cited by 24

What does the developing brain tell us about neural diseases?

Stoeckli, E. T. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08171.x · Cited by 25

Epigenetic Changes During Mechanically Induced Osteogenic Lineage Commitment

Chen, J. C., Chua, M., Bellon, R. B., & Jacobs, C. R. (2015) · Journal of Biomechanical Engineering · doi:10.1115/1.4029551 · Cited by 24

Pharmacological interference with the glucocorticoid system influences symptoms and lifespan in a mouse model of Rett syndrome

Braun, S. B., Kottwitz, D., & Nuber, U. A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr602 · Cited by 24

VPA Alleviates Neurological Deficits and Restores Gene Expression in a Mouse Model of Rett Syndrome

Guo, W., Tsujimura, K., Maky Otsuka, I., Irie, K., Igarashi, K., Nakashima, K., & Zhao, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100215 · Cited by 24

The molecular basis of depression: implications of sex-related differences in epigenetic regulation

Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.708004 · Cited by 23

Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis

Bajikar, S. S., Zhou, J., O’Hara, R. A., Tirumala, H. P., Durham, M. A., Trostle, A. J., Dias, M., Shao, Y., Chen, H., Wang, W., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.11.006 · Cited by 25

Batch Effects Correction with Unknown Subtypes

Luo, X., & Wei, Y. (2018) · Journal of the American Statistical Association · doi:10.1080/01621459.2018.1497494 · Cited by 22

Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to MECP2 Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain

Buist, M., Tobgy, N. E., Shevkoplyas, D., Genung, M., Sher, A. A., Pejhan, S., & Rastegar, M. (2022) · Cells · doi:10.3390/cells11091442 · Cited by 24

Sex disparate gut microbiome and metabolome perturbations precede disease progression in a mouse model of Rett syndrome

Neier, K. E., Grant, T. E., Palmer, R. L., Chappell, D., Hakam, S. M., Yasui, K. M., Rolston, M., Settles, M. L., Hunter, S. S., Madany, A. M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02915-3 · Cited by 24

Strategies for Manipulating Microglia to Determine Their Role in the Healthy and Diseased Brain

Parajuli, B., & Koizumi, S. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03742-6 · Cited by 25

Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC‐Based Models

Fernández‐Santiago, R., & Ezquerra, M. (2015) · Stem Cells International · doi:10.1155/2016/9464591 · Cited by 24

Retinal Progenitor Cells, Differentiation, and Barriers to Cell Cycle Reentry

Davis, D. M., & Dyer, M. A. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385044-7.00006-0 · Cited by 24

The increase in body weight induced by lack of methyl CpG binding protein‐2 is associated with altered leptin signalling in the hypothalamus

Torres‐Andrade, R., Moldenhauer, R., Gutierrez‐Bertín, N., Soto‐Covasich, J., Mancilla‐Medina, C., Ehrenfeld, C., & Kerr, B. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.079798 · Cited by 53

Ube3a/E6AP is involved in a subset of MeCP2 functions

Kim, S., Chahrour, M. H., Ben‐Shachar, S., & Lim, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.036 · Cited by 23

Translational research

Khwaja, O., & Şahin, M. (2011) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32834c9251 · Cited by 23

Mecp2 Truncation in Male Mice Promotes Affiliative Social Behavior

Pearson, B. L., Defensor, E. B., Pobbe, R. L. H., Yamamoto, L. H. L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9501-2 · Cited by 24

Differential regulation of MeCP2 and PP1 in passive or voluntary administration of cocaine or food

Bodetto, S. P., Romieu, P., Sartori, M., Tesone-Coelho, C., Majchrzak, M. J., Barbelivien, A., Zwiller, J., & Anglard, P. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000972 · Cited by 22

Altered responses of MeCP2-deficient mouse brain stem to severe hypoxia

Kron, M., Zimmermann, J. L., Dutschmann, M., Funke, F., & Müller, M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00822.2010 · Cited by 23

Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome

Montgomery, K. R., Titus, A. S. C. L. S., Wang, L., & D’Mello, S. R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1046-4 · Cited by 23

High-fat diet accelerates extreme obesity with hyperphagia in female heterozygous Mecp2-null mice

Fukuhara, S., Nakajima, H., Sugimoto, S., Kodo, K., Shigehara, K., Morimoto, H., Tsuma, Y., Moroto, M., Mori, J., Kosaka, K., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210184 · Cited by 23

MeCP2 and Major Satellite Forward RNA Cooperate for Pericentric Heterochromatin Organization

Fioriniello, S., Csukonyi, E., Marano, D., Brancaccio, A., Madonna, M., Zarrillo, C., Romano, A., Marracino, F., Matarazzo, M. R., D’Esposito, M., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.11.006 · Cited by 22

Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes

Su, D., Cha, Y. M., & West, A. E. (2012) · Epigenetics · doi:10.4161/epi.7.2.18907 · Cited by 24

ZmMBD101 is a DNA‐binding protein that maintains Mutator elements chromatin in a repressive state in maize

Questa, J. I., Rius, S. P., Casadevall, R., & Casati, P. (2015) · Plant Cell & Environment · doi:10.1111/pce.12604 · Cited by 22

Comparative analysis of linker histone H1, MeCP2, and HMGD1 on nucleosome stability and target site accessibility

Riedmann, C., & Fondufe‐Mittendorf, Y. N. (2016) · Scientific Reports · doi:10.1038/srep33186 · Cited by 22

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus

Brito, D. V. C., Karaca, K. G., Kupke, J., Frank, L., & Oliveira, A. M. M. (2020) · Molecular Brain · doi:10.1186/s13041-020-00695-1 · Cited by 22

Effect of maternal zinc deficiency on offspring health: The epigenetic impact

Sanusi, K. O., Ibrahim, K. G., Abubakar, B., Malami, I., Bello, M. B., Imam, M. U., & Abubakar, M. B. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126731 · Cited by 22

Pre-clinical Investigation of Rett Syndrome Using Human Stem Cell-Based Disease Models

Haase, F., Coorey, B., Riley, L. G., Cantrill, L. C., Tam, P., & Gold, W. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.698812 · Cited by 22

Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer's disease

Lee, S.-J., Kim, T. K., Choi, J. E., Choi, Y., You, M., Ryu, J., Chun, Y. L., Ham, S., Hyeon, S. J., Ryu, H., et al. (2022) · Theranostics · doi:10.7150/thno.68439 · Cited by 22

Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2

Ortega-Alarcón, D., Claveria‐Gimeno, R., Vega, S., Kalani, L., Jorge-Torres, O. C., Esteller, M., Ausió, J., Abián, O., & Velázquez‐Campoy, A. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae051 · Cited by 22

Differential methylation of the micro‐RNA 7b gene targets postnatal maturation of murine neuronal Mecp2 gene expression

Chen, Y., Shin, B., Thamotharan, S., & Devaskar, S. U. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22126 · Cited by 23

Mammalian methyl‐binding proteins: What might they do?

Joulie, M., Miotto, B., & Defossez, P. (2010) · BioEssays · doi:10.1002/bies.201000057 · Cited by 25

Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis

Herrera, J. A., Ward, C. S., Wehrens, X. H. T., & Neul, J. L. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw326 · Cited by 22

Familial cases and male cases with MECP2 mutations

Zhang, Q., Zhao, Y., Bao, X., Luo, J. J., Zhang, X., Li, J., Wei, L., & Wu, X. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32534 · Cited by 22

MeCP2 interacts with chromosomal microRNAs in brain

Khan, A. W., Ziemann, M., Rafehi, H., Maxwell, S., Ciccotosto, G. D., & El‐Osta, A. (2017) · Epigenetics · doi:10.1080/15592294.2017.1391429 · Cited by 23

Who's your daddy? Behavioral and epigenetic consequences of paternal drug exposure

Nieto, S. J., & Kosten, T. A. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.07.002 · Cited by 22

Mecp2Deletion from Cholinergic Neurons Selectively Impairs Recognition Memory and Disrupts Cholinergic Modulation of the Perirhinal Cortex

Ballinger, E. C., Schaaf, C. P., Patel, A. J., Maio, A. D., Tao, H., Talmage, D. A., Zoghbi, H. Y., & Role, L. W. (2019) · eNeuro · doi:10.1523/eneuro.0134-19.2019 · Cited by 22

Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis

Lu, T., Klein, K., Colmegna, I., Lora, M., Greenwood, C. M. T., & Hudson, M. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0602-8 · Cited by 21

Alcohol consumption alters Gdnf promoter methylation and expression in rats

Maier, H. B., Neyazi, M., Neyazi, A., Hillemacher, T., Pathak, H., Rhein, M., Bleich, S., Goltseker, K., Sadot-Sogrin, Y., Even‐Chen, O., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.10.020 · Cited by 22

Current Perspectives on the Neurobiology of Drug Addiction: A Focus on Genetics and Factors Regulating Gene Expression

Duncan, J. R. (2012) · ISRN Neurology · doi:10.5402/2012/972607 · Cited by 22

MeCP2 involvement in the regulation of neuronal -tubulin production

Abuhatzira, L., Shemer, R., & Razin, A. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp048 · Cited by 22

Oxidized Cytosine Metabolites Offer a Fresh Perspective for Active DNA Demethylation

Ladwein, K. I., & Jung, M. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201106690 · Cited by 21

MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

Zhang, Y., Zhu, Y., Cao, S.-X., Sun, P., Yang, J.-M., Xia, Y., Xie, S., Yu, X.-D., Fu, J., Shen, C.-J., et al. (2020) · eLife · doi:10.7554/elife.55342 · Cited by 21

Phenotypic features in MECP2 duplication syndrome: Effects of age

Peters, S. U., Fu, C., Marsh, E. D., Benke, T. A., Suter, B., Skinner, S. A., Lieberman, D. N., Standridge, S. M., Jones, M. D., Beisang, A., et al. (2020) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61956 · Cited by 21

Sex Dimorphism in Pulmonary Hypertension: The Role of the Sex Chromosomes

Kostyunina, D. S., & McLoughlin, P. (2021) · Antioxidants · doi:10.3390/antiox10050779 · Cited by 21

Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations

Chen, M., Li, S., Srinivasasainagendra, V., Sharma, M., Li, Z., Tiwari, H. K., Tollefsbol, T. O., & Li, Y. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac009 · Cited by 41

MicroRNAs in drug addiction: Current status and future perspectives

Zhao, Y., Qin, F., Han, S., Li, S., Zhao, Y., Wang, H., Tian, J., & Cen, X. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108215 · Cited by 22

Plasma membrane and brain dysfunction of the old: Do we age from our membranes?

Martín, M. G., & Dotti, C. G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1031007 · Cited by 24

Exercise epigenetics is fueled by cell bioenergetics: Supporting role on brain plasticity and cognition

Gómez‐Pinilla, F., & Thapak, P. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.04.237 · Cited by 24

Over-Expression of Either MECP2_e1 or MECP2_e2 in Neuronally Differentiated Cells Results in Different Patterns of Gene Expression

Orlic-Milacic, M., Kaufman, L., Mikhailov, A., Cheung, A. Y. L., Mahmood, H., Ellis, J., Gianakopoulos, P. J., Minassian, B. A., & Vincent, J. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091742 · Cited by 23

Epigenetic mechanisms in Alzheimer's disease: progress but much to do

Balázs, R., Vernon, J. D. R., & Hardy, J. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.024 · Cited by 21

Novel Tools, Classic Techniques: Evolutionary Studies Using Primate Pluripotent Stem Cells

Hrvoj-Mihić, B., Marchetto, M. C., Gage, F. H., Semendeferi, K., & Muotri, A. R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.007 · Cited by 22

Abnormalities of the DNA Methylation Mark and Its Machinery: An Emerging Cause of Neurologic Dysfunction

Weissman, J., Naidu, S., & Bjornsson, H. T. (2014) · Seminars in Neurology · doi:10.1055/s-0034-1386763 · Cited by 22

Epigenetic Regulation of SNAP25 Prevents Progressive Glutamate Excitotoxicty in Hypoxic CA3 Neurons

Biswal, S., Das, D., Barhwal, K. K., Kumar, A., Nag, T. C., Thakur, M. K., Hota, S. K., & Kumar, B. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0156-0 · Cited by 21

Hypermethylated LTR retrotransposon exhibits enhancer activity

Hu, T., Zhu, X., Pi, W., Yu, M., Shi, H., & Tuan, D. Y. H. (2017) · Epigenetics · doi:10.1080/15592294.2017.1289300 · Cited by 21

The potential impact of recent insights into proteomic changes associated with glaucoma

Funke, S., Perumal, N., Bell, K. C., Pfeiffer, N., & Grus, F. H. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1298448 · Cited by 21

Potential role of DNA methylation as a facilitator of target search processes for transcription factors through interplay with methyl-CpG-binding proteins

Kemme, C. A., Marquez, R., Luu, R. H., & Iwahara, J. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx387 · Cited by 21

Selective Activation of Striatal NGF-TrkA/p75NTR/MAPK Intracellular Signaling in Rats That Show Suppression of Methamphetamine Intake 30 Days following Drug Abstinence

Torres, O. V., Jayanthi, S., McCoy, M. T., & Cadet, J. L. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx105 · Cited by 21

Curcumin restores hepatic epigenetic changes in propylthiouracil(PTU)Induced hypothyroid male rats: A study on DNMTs, MBDs, GADD45a, C/EBP-β and PCNA

Bunker, S. K., Dutta, A., Pradhan, J., Dandapat, J., & Chainy, G. B. N. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.10.050 · Cited by 21

MeCP2 inhibits cell functionality through FoxO3a and autophagy in endothelial progenitor cells

Zha, S., Li, Z., Chen, S., Liu, F., & Wang, F. (2019) · Aging · doi:10.18632/aging.102183 · Cited by 21

Effect of mobile phone signal radiation on epigenetic modulation in the hippocampus of Wistar rat

Kumar, R., Deshmukh, P. S., Sharma, S., & Banerjee, B. D. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110297 · Cited by 21

SnapShot: Ca2+-Dependent Transcription in Neurons

Zieg, J., Greer, P. L., & Greenberg, M. E. (2008) · Cell · doi:10.1016/j.cell.2008.09.010 · Cited by 21

The Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota

Sudo, N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802304-4.00013-x · Cited by 22

A central role for MeCP2 in the epigenetic repression of miR-200c during epithelial-to-mesenchymal transition of glioma

Bian, E., Chen, X., Xu, Y., Ji, X., Cheng, M., Wang, H., Fang, Z., & Zhao, B. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1341-6 · Cited by 20

High rate of HDR in gene editing of p.(Thr158Met) MECP2 mutational hotspot

Croci, S., Carriero, M. L., Capitani, K., Daga, S., Donati, F., Frullanti, E., Lamacchia, V., Tita, R., Giliberti, A., Valentino, F., et al. (2020) · European Journal of Human Genetics · doi:10.1038/s41431-020-0624-x · Cited by 22

Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling

Miranda‐Lourenço, C., Duarte, S. T., Palminha, C., Gaspar, C., Rodrigues, T. M., Magalhães-Cardoso, M. T., Rei, N., Colino-Oliveira, M., Gomes, R., Ferreira, S. G. F., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105043 · Cited by 20

Involvement of myocyte enhancer factor 2c in the pathogenesis of autism spectrum disorder

Chaudhary, R., Agarwal, V., Kaushik, A. S., & Rehman, M. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06854 · Cited by 21

Revelation of Pivotal Genes Pertinent to Alzheimer’s Pathogenesis: A Methodical Evaluation of 32 GEO Datasets

Sree, G. N. S. H., Rajalekshmi, S. G., & Burri, R. R. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01919-2 · Cited by 19

Genetic and Epigenetic Alterations in Autism Spectrum Disorder

Oztenekecioglu, B., Mavis, M., Osum, M., & Kalkan, R. (2021) · Global Medical Genetics · doi:10.1055/s-0041-1735540 · Cited by 24

Electrophysiological and Behavioral Evidence for Hyper- and Hyposensitivity in Rare Genetic Syndromes Associated with Autism

Neklyudova, A. K., Smirnov, K., Rebreikina, A. B., Martynova, O., & Sysoeva, O. (2022) · Genes · doi:10.3390/genes13040671 · Cited by 22

mTOR-Dependent Spine Dynamics in Autism

Chaudry, S., & Vasudevan, N. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.877609 · Cited by 23

Bioinformatics analysis of prognostic value and immunological role of MeCP2 in pan-cancer

Wang, Y., Zhang, Y., Wang, F., Li, T., Song, X., Shi, H., Du, J., Zhang, H., Jing, H., Han, J., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-21328-8 · Cited by 21

BDNF exon IV promoter methylation and antidepressant action: a complex interplay

Pathak, H., Borchert, A., Garaali, S., Burkert, A., & Frieling, H. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01415-3 · Cited by 21

Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids

Trudler, D., Ghatak, S., Bula, M., Parker, J., Talantova, M. V., Luevanos, M., Labra, S. R., Grabauskas, T., Noveral, S. M., Teranaka, M., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02761-9 · Cited by 24

Structural variant allelic heterogeneity in MECP2 duplication syndrome provides insight into clinical severity and variability of disease expression

Pehli̇van, D., Bengtsson, J. D., Bajikar, S. S., Grochowski, C. M., Lun, M. Y., Gandhi, M., Jolly, A., Trostle, A. J., Harris, H. K., Suter, B., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01411-7 · Cited by 22

Elevated IKKα Accelerates the Differentiation of Human Neuronal Progenitor Cells and Induces MeCP2-Dependent BDNF Expression

Khoshnan, A., & Patterson, P. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041794 · Cited by 21

The involvement of epigenetic defects in mental retardation

Franklin, T. B., & Mansuy, I. M. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.04.001 · Cited by 20

Aberrant Dendritic Excitability: A Common Pathophysiology in CNS Disorders Affecting Memory?

Nestor, M. W., & Hoffman, D. A. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8265-x · Cited by 20

Effects ofω-3 PUFAs Supplementation on Myocardial Function and Oxidative Stress Markers in Typical Rett Syndrome

Maffei, S., Felice, C. D., Cannarile, P., Leoncini, S., Signorini, C., Pecorelli, A., Montomoli, B., Lunghetti, S., Ciccoli, L., Durand, T., et al. (2014) · Mediators of Inflammation · doi:10.1155/2014/983178 · Cited by 20

The L1 adhesion molecule normalizes neuritogenesis in Rett syndrome-derived neural precursor cells

Yoo, M., Carromeu, C., Kwon, O., Muotri, A. R., & Schachner, M. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.073 · Cited by 22

The promise of induced pluripotent stem cells for neurodevelopmental disorders

Linda, K., Fiuza, C., & Kasri, N. N. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.009 · Cited by 22

The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors

Morgan, R. K., Anderson, G. R., Araç, D., Aust, G., Balenga, N. A. B., Boucard, A. A., Bridges, J. P., Engel, F. B., Formstone, C. J., Glitsch, M. D., et al. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14094 · Cited by 19

Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons

Seabra, C. M., Aneichyk, T., Erdin, S., Tai, D. J. C., de Esch, C. E. F., Razaz, P., An, Y., Manavalan, P., Ragavendran, A., Stortchevoi, A., et al. (2020) · Molecular Autism · doi:10.1186/s13229-020-00354-1 · Cited by 20

MeCP2 prevents against sustained ketamine-induced synaptic depression at inhibitory synapses

Piazza, M. K., Weit, A. R., Kavalali, E. T., Neul, J. L., & Monteggia, L. M. (2025) · iScience · doi:10.1016/j.isci.2025.112485 · Cited by 3

Untitled work

(2013) · PubMed · Cited by 22

In Brief

(2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2451

MeCP2 as an Activator of Gene Expression

Horvath, P. M., & Monteggia, L. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2017.11.005 · Cited by 47

Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus

Ben-Shachar, S., Chahrour, M., Thaller, C., Shaw, C. A., & Zoghbi, H. Y. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp181 · Cited by 253

MECP2: A Multifunctional Protein Supporting Brain Complexity

Vacca, M., Ragione, F. D., Tripathi, K. P., Scalabrì, F., & D’Esposito, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-23497-7_8

The methyl-CpG-binding protein MeCP2 and neurological disease

Bird, A. P. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360575 · Cited by 69