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MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
Open accessAbstract
Mutations in the gene encoding the transcriptional repressor methyl-CpG binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome. Loss of function as well as increased dosage of the MECP2 gene cause a host of neuropsychiatric disorders. To explore the molecular mechanism(s) underlying these disorders, we examined gene expression patterns in the hypothalamus of mice that either lack or overexpress MeCP2. In both models, MeCP2 dysfunction induced changes in the expression levels of thousands of genes, but unexpectedly the majority of genes (∼85%) appeared to be activated by MeCP2. We selected six genes and confirmed that MeCP2 binds to their promoters. Furthermore, we showed that MeCP2 associates with the transcriptional activator CREB1 at the promoter of an activated target but not a repressed target. These studies suggest that MeCP2 regulates the expression of a wide range of genes in the hypothalamus and that it can function as both an activator and a repressor of transcription.
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“While Mecp2 mutant mice are an excellent model for RTT, elimination of MeCP2 affects the expression of a profound number of pathways in the CNS, making it difficult to pinpoint which ones play a key role in pathology [77,89,90].”
From Rett syndrome: a neurological disorder with metabolic components (2018) · cites this paper as [77]
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“However, MeCP2 may also facilitate transcriptional activation [77], chromatin compaction [78,79] and mRNA splicing [80,81], while also interacting with a host of other regulatory proteins involved in a variety of molecular pathways [81–84].”
From Rett syndrome: a neurological disorder with metabolic components (2018) · cites this paper as [77]
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“Altogether, multiple studies suggest that genes can be activated or repressed by MeCP2, depending upon the cellular context [77,89,90], suggesting that MeCP2 may be defined as a transcriptional modulator.”
From Rett syndrome: a neurological disorder with metabolic components (2018) · cites this paper as [77]
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“These data are consistent with another study showing that MeCP2 binding to methylated DNA has a biphasic impact on transcription.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [123]
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990
Self-citationNan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,791
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
Guy, J., Hendrich, B., Holmes, M., Martin, J. E., & Bird, A. (2001) · Nature Genetics · doi:10.1038/85899 · Cited by 1,558
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232
Zhou, Z., Hong, E. J., Cohen, S., Zhao, W.-N., Ho, H.-Y. H., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.037 · Cited by 877
Mild overexpression of MeCP2 causes a progressive neurological disorder in mice
Collins, A. L., Levenson, J. M., Vilaythong, A. P., Richman, R., Armstrong, D. L., Noebels, J. L., David Sweatt, J., & Zoghbi, H. Y. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh282 · Cited by 626
Self-citationThe disease progression of Mecp2 mutant mice is affected by the level of BDNF expression
Chang, Q., Khare, G., Dani, V., Nelson, S., & Jaenisch, R. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.027 · Cited by 578
MeCP2 Controls Excitatory Synaptic Strength by Regulating Glutamatergic Synapse Number
Chao, H.-T., Zoghbi, H. Y., & Rosenmund, C. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.018 · Cited by 511
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Research works printed but not linked: 3
- C. L. Martinet al., Am. J. Med. Genet. B. Neuropsychiatr. Genet.144, 869 (2007).
- H. Caldeira Araujoet al., Am. J. Med. Genet. A.133, 122 (2005).
- We thank members of the Zoghbi laboratory for their thoughtful comments Z. Yin for technical assistance M. Shinawi and A. Tawil for technical advice Y. Klisch for the art work and J. Lim J. Neul and M. Greenberg for reagents. The Baylor College of Medicine Microarray Core Facility performed the microarray experiments. This work was funded by NIH/National Institute of Neurological Disorders and Stroke grant NS057819 (H.Z.) National Institute of Child Health and Human Development Mental Retardation and Developmental Disabilities Research Center HD024064 (H.Z.) the International Rett Syndrome Foundation and the Simons Foundation. H.Z. is a Howard Hughes Medical Institute investigator. The microarray data have been deposited in the National Center for Biotechnology Information Gene Expression Omnibus (GEO) (www.ncbi.nlm.nih.gov/geo) and are accessible through GEO Series accession number GSE11150.
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Gold, W. A., Percy, A. K., Neul, J. L., Cobb, S., Pozzo‐Miller, L. D., Issar, J. K., Ben‐Zeev, B., Vignoli, A., & Kaufmann, W. E. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00568-0 · Cited by 88
Sunahori, K., Juang, Y., & Tsokos, G. C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1500 · Cited by 76
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Ziats, M. N., & Rennert, O. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024691 · Cited by 75
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Gatta, E., Grayson, D. R., Auta, J., Saudagar, V., Dong, E., Chen, Y., Krishnan, H. R., Drnevich, J. M., Pandey, S. C., & Guidotti, A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0449-6 · Cited by 81
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Gennarino, V. A., Alcott, C. E., Chen, C., Chaudhury, A., Gillentine, M. A., Rosenfeld, J. A., Parikh, S., Wheless, J. W., Roeder, E. R., Horovitz, D. D. G., et al. (2015) · eLife · doi:10.7554/elife.10782 · Cited by 74
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Kernohan, K. D., Vernimmen, D., Gloor, G. B., & Bérubé, N. G. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku564 · Cited by 72
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Mayer, S., Gilsbach, R., Preißl, S., Ordonez, E. B. M., Schnick, T., Beetz, N., Lother, A., Rommel, C., Ihle, H., Bugger, H., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.306721 · Cited by 70
Chung, W. W., & Hudziak, J. J. (2017) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2016.12.017 · Cited by 77
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Yan, X., Zhao, X., Li, J., He, L., & Xu, M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.12.016 · Cited by 71
Stuss, D. P., Boyd, J. D., Levin, D. B., & Delaney, K. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031896 · Cited by 72
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Livide, G., Patriarchi, T., Amenduni, M., Amabile, S., Yasui, D. H., Calcagno, E., Rizzo, C. L., Falco, G. D., Ulivieri, C., Ariani, F., et al. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.81 · Cited by 68
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Yin, J., & Schaaf, C. P. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4942 · Cited by 78
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Weaver, I. C. G., Hellstrom, I. C., Brown, S. E., Andrews, S. D., Dymov, S., Diorio, J., Zhang, T.-Y., Szyf, M., & Meaney, M. J. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0513 · Cited by 67
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Hill, D. S., Cabrera, R. M., Schultz, D. W., Zhu, H., Lü, W., Finnell, R. H., & Wlodarczyk, B. J. (2015) · Behavioural Neurology · doi:10.1155/2015/426263 · Cited by 67
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Pohodich, A. E., Yalamanchili, H. K., Raman, A. T., Wan, Y., Gundry, M. C., Hao, S., Jin, H., Tang, J., Liu, Z., & Zoghbi, H. Y. (2018) · eLife · doi:10.7554/elife.34031 · Cited by 66
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Ling, K., Hewitt, C., Tan, K.-L., Cheah, P.-S., Vidyadaran, S., Lai, M. I., Lee, H.-C., Simpson, K., Hyde, L., Pritchard, M. A., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-624 · Cited by 68
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Metadata
- Authors
- Chahrour, M., Jung, S. Y., Shaw, C., Zhou, X., Wong, S. T. C., Qin, J., & Zoghbi, H. Y.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Zoghbi, Huda Y.
- Venue
- Science
- Published
- 2008-05-30
- Volume
- 320
- Issue
- 5880
- Pages
- 1224-1229
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2443785
- OpenAlex
- W2039276157
- Cited by
- 1,823
- References
- 22
- Citations by year
- 2026: 53 · 2025: 55 · 2024: 76 · 2023: 67 · 2022: 84 · 2021: 95 · 2020: 96 · 2019: 90 · 2018: 69 · 2017: 131 · 2016: 133 · 2015: 113 · 2014: 131 · 2013: 153 · 2012: 128
- FWCI
- 66.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (NS057819, R01NS057819)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 024064, P30HD024064)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- MeCP2, Rett syndrome, transcriptional repression, transcriptional activation, CREB1, promoter binding, hypothalamus, gene expression profiling, neuropsychiatric disorders, neurodevelopmental disorders
- MeSH terms
- Animals, Disease Models, Animal, Gene Expression Regulation, Hypothalamic Diseases, Hypothalamus, Male, Mice, Inbred C57BL, Nerve Tissue Proteins, Nervous System Diseases, Protein Binding, Repressor Proteins, Transcription Factors, Rett Syndrome, Transcriptional Activation, Cyclic AMP Response Element-Binding Protein, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Mice, Methyl-CpG-Binding Protein 2
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