The molecular basis of depression: implications of sex-related differences in epigenetic regulation

Prevalence, Severity, and Comorbidity of 12-Month DSM-IV Disorders in the National Comorbidity Survey Replication

Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works

Chromatin modifications and their function

Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325 · see citing works

Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010

Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61611-6 · Cited by 6,006 · see citing works

Molecular Mechanisms of Long Noncoding RNAs

Wang, K., & Chang, H. Y. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.018 · Cited by 4,390 · see citing works

Depression

Malhi, G. S., & Mann, J. J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31948-2 · Cited by 4,099 · see citing works

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works

Neurobiology of Depression

Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works

DNA methylation landscapes: Provocative insights from epigenomics

Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039 · see citing works

Stress and Depression

Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979 · see citing works

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791 · see citing works

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700 · cited 1× · see citing works

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Howard, D. M., Adams, M. J., Clarke, T.-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0326-7 · Cited by 2,565 · see citing works

Neural consequences of enviromental enrichment

van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works

Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works

Trauma and Posttraumatic Stress Disorder in the Community: The 1996 Detroit Area Survey of Trauma

Breslau, N., Kessler, R. C., Chilcoat, H. D., Schultz, L. R., Davis, G. C., & Andreski, P. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.626 · Cited by 2,407 · see citing works

Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 1× · see citing works

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

Cech, T. R., & Steitz, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,270 · see citing works

Sex and depression in the National Comorbidity Survey, I: lifetime prevalence, chronicity and recurrence

Kessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207 · see citing works

Function and regulation of CREB family transcription factors in the nervous system

Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127 · see citing works

X-inactivation profile reveals extensive variability in X-linked gene expression in females

Carrel, L., & Willard, H. F. (2005) · Nature · doi:10.1038/nature03479 · Cited by 2,097 · see citing works

STRESS AND HIPPOCAMPAL PLASTICITY

McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087 · see citing works

Neurotrophins and Neuronal Plasticity

Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927 · see citing works

The brain reward circuitry in mood disorders

Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works

Global epigenomic reconfiguration during mammalian brain development

Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., Lucero, J., Huang, Y., Dwork, A. J., Schultz, M. D., et al. (2013) · Science · doi:10.1126/science.1237905 · Cited by 1,830 · see citing works

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

Chahrour, M., Jung, S. Y., Shaw, C., Zhou, X., Wong, S. T. C., Qin, J., & Zoghbi, H. Y. (2008) · Science · doi:10.1126/science.1153252 · Cited by 1,823 · see citing works

A brain-specific microRNA regulates dendritic spine development

Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786 · see citing works

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644 · see citing works

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577 · see citing works

Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex

McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574 · see citing works

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., et al. (2018) · Nature · doi:10.1038/nature25975 · Cited by 1,422 · see citing works

Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood

Gould, E., Woolley, C., Frankfurt, M., & McEwen, B. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01286.1990 · Cited by 1,406 · see citing works

Epigenetic regulation in psychiatric disorders

Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400 · see citing works

Human Hippocampal Neurogenesis Persists throughout Aging

Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345 · see citing works

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206 · see citing works

Adult hippocampal neurogenesis in depression

Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works

Neurobiology of resilience

Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works

Estrogen Stimulates a Transient Increase in the Number of New Neurons in the Dentate Gyrus of the Adult Female Rat

Tanapat, P., Hastings, N. B., Reeves, A. J., & Gould, E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05792.1999 · Cited by 978 · see citing works

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

Gao, J., Wang, W.-Y., Mao, Y.-W., Gräff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., & Tsai, L.-H. (2010) · Nature · doi:10.1038/nature09271 · Cited by 975 · see citing works

The antidepressant fluoxetine restores plasticity in the adult visual cortex

Vetencourt, J. F. M., Sale, A., Viegi, A., Baroncelli, L., De Pasquale, R., F. O'Leary, O., Castrén, E., & Maffei, L. (2008) · Science · doi:10.1126/science.1150516 · Cited by 890 · see citing works

The science of resilience: implications for the prevention and treatment of depression

Southwick, S. M., & Charney, D. S. (2012) · Science · doi:10.1126/science.1222942 · Cited by 875 · see citing works

An epigenetic blockade of cognitive functions in the neurodegenerating brain

Gräff, J., Rei, D., Guan, J.-S., Wang, W.-Y., Seo, J., Hennig, K. M., Nieland, T. J. F., Fass, D. M., Kao, P. F., Kahn, M., et al. (2012) · Nature · doi:10.1038/nature10849 · Cited by 853 · see citing works

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

Flavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832 · see citing works

The neuronal microRNA system

Kosik, K. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2037 · Cited by 823 · see citing works

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

Szulwach, K. E., Li, X., Li, Y., Song, C., Wu, H., Dai, Q., Irier, H. A., Upadhyay, A. K., Gearing, M., Levey, A. I., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2959 · Cited by 818 · see citing works

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

Kang, H. J., Voleti, B., Hajszan, T., Rajkowska, G., Stockmeier, C. A., Licznerski, P., Lepack, A., Majik, M. S., Jeong, L. S., Banasr, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2886 · Cited by 808 · see citing works

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015) · Nature Neuroscience · doi:10.1038/nn.3922 · Cited by 755 · see citing works

Sex-specific transcriptional signatures in human depression

Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works

Gender Differences in Treatment Response to Sertraline Versus Imipramine in Chronic Depression

Kornstein, S. G., Schatzberg, A. F., Thase, M. E., Yonkers, K. A., McCullough, J. P., Keitner, G. I., Gelenberg, A. J., Thomas, S., Harrison, W. M., & Keller, M. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.9.1445 · Cited by 712 · see citing works

Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity

Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710 · see citing works

An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma

Sumazin, P., Yang, X., Chiu, H., Chung, W., Iyer, A. P., Llobet‐Navàs, D., Rajbhandari, P., Bansal, M., Guarnieri, P., Silva, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.041 · Cited by 692 · see citing works

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation

Modarresi, F., Faghihi, M. A., López-Toledano, M. A., Fatemi, R. P., Magistri, M., Brothers, S. P., van der Brug, M. P., & Wahlestedt, C. (2012) · Nature Biotechnology · doi:10.1038/nbt.2158 · Cited by 668 · see citing works

Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat

VIAU, V., & MEANEY, M. J. (1991) · Endocrinology · doi:10.1210/endo-129-5-2503 · Cited by 666 · see citing works

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Casarotto, P. C., Girych, M., Fred, S. M., Kovaleva, V., Moliner, R., Enkavi, G., Biojone, C., Cannarozzo, C., Sahu, M. P., Kaurinkoski, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.034 · Cited by 663 · see citing works

From Synapse to Nucleus: Calcium-Dependent Gene Transcription in the Control of Synapse Development and Function

Greer, P. L., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.002 · Cited by 661 · see citing works

Rapid actions of plasma membrane estrogen receptors

Kelly, M. J., & Levin, E. R. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00377-0 · Cited by 643 · see citing works

NONCODE 2016: an informative and valuable data source of long non-coding RNAs

Zhao, Y., Li, H., Fang, S., Kang, Y., wu, W., Hao, Y., Li, Z., Bu, D., Sun, N., Zhang, M. Q., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1252 · Cited by 643 · see citing works

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

Moda-Sava, R. N., Murdock, M. H., Parekh, P. K., Fetcho, R. N., Huang, B. S., Huynh, T. N., Witztum, J., Shaver, D. C., Rosenthal, D. L., Alway, E. J., et al. (2019) · Science · doi:10.1126/science.aat8078 · Cited by 643 · see citing works

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Thompson, P. M., Jahanshad, N., Ching, C. R. K., Salminen, L. E., Thomopoulos, S. I., Bright, J. K., Baune, B. T., Bertolín, S., Bralten, J., Bruin, W. B., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0705-1 · Cited by 638 · see citing works

Antidepressant Actions of Histone Deacetylase Inhibitors

Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612 · see citing works

Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli

Renthal, W., Maze, I., Krishnan, V., Covington, H. E., Xiao, G., Kumar, A., Russo, S. J., Graham, A., Tsankova, N., Kippin, T. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.032 · Cited by 599 · see citing works

Is mood chemistry?

Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

Qureshi, I., & Mehler, M. F. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3234 · Cited by 561 · see citing works

Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress

Galea, L. A. M., McEwen, B. S., Tanapat, P., Deak, T., Spencer, R. L., & Dhabhar, F. S. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00233-9 · Cited by 540 · see citing works

Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones

Heck, A., & Handa, R. J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0167-9 · Cited by 532 · see citing works

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

Nagy, C., Maitra, M., Tanti, A., Suderman, M., Théroux, J.-F., Davoli, M. A., Perlman, K., Yerko, V., Wang, Y. C., Tripathy, S. J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0621-y · Cited by 532 · see citing works

Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy

Furmark, T., Tillfors, M., Marteinsdottir, I., Fischer, H., Pissiota, A., Långström, B., & Fredrikson, M. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.425 · Cited by 530 · see citing works

Decoding the Epigenetic Language of Neuronal Plasticity

Borrelli, E., Nestler, E. J., Allis, C. D., & Sassone‐Corsi, P. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.012 · Cited by 529 · see citing works

Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner

Ulrich‐Lai, Y. M., Figueiredo, H. F., Ostrander, M. M., Choi, D. C., Engeland, W. C., & Herman, J. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00070.2006 · Cited by 497 · see citing works

Use of fMRI to Predict Recovery From Unipolar Depression With Cognitive Behavior Therapy

Siegle, G. J., Carter, C. S., & Thase, M. E. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.4.735 · Cited by 495 · see citing works

Gender differences in chronic major and double depression

Kornstein, S. G., Schatzberg, A. F., Thase, M. E., Yonkers, K. A., McCullough, J. P., Keitner, G. I., Gelenberg, A. J., Ryan, C. E., Hess, A., Harrison, W. M., et al. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00158-5 · Cited by 489 · see citing works

MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants

Baudry, A., Mouillet-Richard, S., Schneider, B., Launay, J.-M., & Kellermann, O. (2010) · Science · doi:10.1126/science.1193692 · Cited by 480 · see citing works

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

Farrelly, L. A., Thompson, R. E., Zhao, S., Lepack, A. E., Lyu, Y., Bhanu, N. V., Zhang, B., Loh, Y. E., Ramakrishnan, A., Vadodaria, K. C., et al. (2019) · Nature · doi:10.1038/s41586-019-1024-7 · Cited by 478 · see citing works

Maternal H3K27me3 controls DNA methylation-independent imprinting

Inoue, A., Jiang, L., Lu, F., Suzuki, T., & Zhang, Y. (2017) · Nature · doi:10.1038/nature23262 · Cited by 467 · see citing works

Stress, epigenetics and depression: A systematic review

Park, C., Rosenblat, J. D., Brietzke, E., Pan, Z., Lee, Y., Cao, B., Zuckerman, H., Kalantarova, A., & McIntyre, R. S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.010 · Cited by 465 · see citing works

Gender differences in depression: Findings from the STAR*D study

Marcus, S. M., Young, E. A., Kerber, K. B., Kornstein, S., Farabaugh, A. H., Mitchell, J., Wisniewski, S. R., Balasubramani, G. K., Trivedi, M. H., & Rush, A. J. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.09.008 · Cited by 456 · see citing works

Epigenetics of the depressed brain: role of histone acetylation and methylation

Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413 · see citing works

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

Nishiyama, A., Yamaguchi, L., Sharif, J., Johmura, Y., Kawamura, T., Nakanishi, K., Shimamura, S., Arita, K., Kodama, T., Ishikawa, F., et al. (2013) · Nature · doi:10.1038/nature12488 · Cited by 410 · see citing works

Gonadal Hormones Affect Spine Synaptic Density in the CA1 Hippocampal Subfield of Male Rats

Léránth, C., Petneházy, Ö., & MacLusky, N. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01588.2003 · Cited by 407 · see citing works

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

Uchida, S., Hara, K., Kobayashi, A., Otsuki, K., Yamagata, H., Hobara, T., Suzuki, T., Miyata, N., & Watanabe, Y. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.023 · Cited by 398 · see citing works

Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress

Hodes, G. E., Pfau, M. L., Purushothaman, I., Ahn, H. F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1392-15.2015 · Cited by 395 · see citing works

Brain feminization requires active repression of masculinization via DNA methylation

Nugent, B. M., Wright, C. L., Shetty, A. C., Hodes, G. E., Lenz, K. M., Mahurkar, A., Russo, S. J., Devine, S. E., & McCarthy, M. M. (2015) · Nature Neuroscience · doi:10.1038/nn.3988 · Cited by 390 · see citing works

Fear erasure in mice requires synergy between antidepressant drugs and extinction training

Karpova, N. N., Pickenhagen, A., Lindholm, J., Tiraboschi, E., Kulesskaya, N., Ágústsdóttir, A., Antila, H., Popova, D., Akamine, Y., Sullivan, R., et al. (2011) · Science · doi:10.1126/science.1214592 · Cited by 382 · see citing works

DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression

Fuchikami, M., Morinobu, S., Segawa, M., Okamoto, Y., Yamawaki, S., Ozaki, N., Inoue, T., Kusumi, I., Koyama, T., Tsuchiyama, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023881 · Cited by 378 · see citing works

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

Muda, M., Theodosiou, A. M., Rodrigues, N. R., Boschert, U., Camps, M., Gilliéron, C., Davies, K. E., Ashworth, A., & Arkinstall, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27205 · Cited by 375 · see citing works

Stressful early life experiences and immune dysregulation across the lifespan

Fagundes, C. P., Glaser, R., & Kiecolt-Glaser, J. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.014 · Cited by 371 · see citing works

The Role of CREB in Depression and Antidepressant Treatment

Blendy, J. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.003 · Cited by 365 · see citing works

Personalized Medicine for Depression: Can We Match Patients With Treatments?

Simon, G. E., & Perlis, R. H. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09111680 · Cited by 365 · see citing works

Neuroplasticity Mediated by Altered Gene Expression

McClung, C. A., & Nestler, E. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301544 · Cited by 347 · see citing works

Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice

Li, C., Brake, W. G., Romeo, R. D., Dunlop, J. C., Gordon, M., Buzescu, R., Magariños, A. M., Allen, P. B., Greengard, P., Luine, V. N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307313101 · Cited by 345 · see citing works

Epigenetic basis of mental illness

Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342 · see citing works

うつ病【JST・京大機械翻訳】

Malhi Gin, S., & John, M. J. (2018) · The Lancet · Cited by 332 · see citing works

GABAA Receptor Promoter Hypermethylation in Suicide Brain: Implications for the Involvement of Epigenetic Processes

Poulter, M. O., Du, L., Weaver, I. C. G., Palkovits, M., Faludi, G., Merali, Z., Szyf, M., & Anisman, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.028 · Cited by 331 · see citing works

cAMP Response Element-Binding Protein Is Essential for the Upregulation of Brain-Derived Neurotrophic Factor Transcription, But Not the Behavioral or Endocrine Responses to Antidepressant Drugs

Conti, A. C., Cryan, J. F., Dalvi, A., Lucki, I., & Blendy, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03262.2002 · Cited by 328 · see citing works

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3090 · Cited by 322 · see citing works

The neuropathology of primary mood disorder

Harrison, P. J. (2002) · Brain · doi:10.1093/brain/awf149 · Cited by 321 · see citing works

MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity

Issler, O., Haramati, S., Paul, E. D., Maeno, H., Navon, I., Zwang, R., Gil, S., Mayberg, H. S., Dunlop, B. W., Menke, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.042 · Cited by 318 · see citing works

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

Nie, X., Kitaoka, S., Tanaka, K., Segi‐Nishida, E., Imoto, Y., Ogawa, A., Nakano, F., Tomohiro, A., Nakayama, K., Taniguchi, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.035 · Cited by 318 · see citing works

The paraventricular nucleus of the hypothalamus – a potential target for integrative treatment of autonomic dysfunction

Ferguson, A. V., Latchford, K. J., & Samson, W. K. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.6.717 · Cited by 316 · see citing works

Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect

Chen, A. C. H., Shirayama, Y., Shin, K.-H., Neve, R. L., & Duman, R. S. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01114-8 · Cited by 314 · see citing works

Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents

Uchida, S., Hara, K., Kobayashi, A., Funato, H., Hobara, T., Otsuki, K., Yamagata, H., McEwen, B. S., & Watanabe, Y. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1436-10.2010 · Cited by 310 · see citing works

Long noncoding RNAs in development and disease of the central nervous system

Ng, S., Lin, L., Soh, B.-S., & Stanton, L. W. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.03.002 · Cited by 308 · see citing works

miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment

Lopez, J. P., Lim, R., Cruceanu, C., Crapper, L., Fasano, C., Labonte, B., Maussion, G., Yang, J. P., Yerko, V., Vigneault, E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3582 · Cited by 308 · see citing works

Astrocytic abnormalities and global DNA methylation patterns in depression and suicide

Nagy, C., Suderman, M., Yang, J., Szyf, M., Mechawar, N., Ernst, C., & Turecki, G. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.21 · Cited by 301 · see citing works

A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy

Huang, L., Xi, Y., Peng, Y., Yang, Y., Huang, X., Fu, Y., Tao, Q., Xiao, J., Yuan, T., An, K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.037 · Cited by 300 · see citing works

A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress

Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works

The molecular bases of the suicidal brain

Turecki, G. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3839 · Cited by 281 · see citing works

HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

Sando, R., Gounko, N., Pieraut, S., Liao, L., Yates, J., & Maximov, A. (2012) · Cell · doi:10.1016/j.cell.2012.09.037 · Cited by 274 · see citing works

X‐chromosome‐located microRNAs in immunity: Might they explain male/female differences?

Pinheiro, I., Dejager, L., & Libert, C. (2011) · BioEssays · doi:10.1002/bies.201100047 · Cited by 273 · see citing works

Human adult neurogenesis across the ages: An immunohistochemical study

Dennis, C. V., Suh, L. S., Rodriguez, M. L., Kril, J. J., & Sutherland, G. T. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12337 · Cited by 265 · see citing works

The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)

Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253 · see citing works

Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes

Lau, P., Verrier, J. D., Nielsen, J. A., Johnson, K. R., Notterpek, L., & Hudson, L. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1932-08.2008 · Cited by 252 · see citing works

Sex Differences in Antidepressant Response in Recent Antidepressant Clinical Trials

Khan, A., Brodhead, A. E., Schwartz, K. A., Kolts, R. L., & Brown, W. A. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000168879.03169.ce · Cited by 252 · see citing works

Sex differences in the antidepressant-like effects of ketamine

Carrier, N., & Kabbaj, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.12.009 · Cited by 251 · see citing works

Sex Differences in Chronic Stress Effects on Memory in Rats

Luine, V. (2002) · Stress · doi:10.1080/1025389021000010549 · Cited by 250 · see citing works

Chronic restraint stress enhances radial arm maze performance in female rats

Bowman, R. E., Zrull, M. C., & Luine, V. N. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02474-x · Cited by 247 · see citing works

Hippocampal Sirtuin 1 signaling mediates depression-like behavior

Abe-Higuchi, N., Uchida, S., Yamagata, H., Higuchi, F., Hobara, T., Hara, K., Kobayashi, A., & Watanabe, Y. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.009 · Cited by 247 · see citing works

Neuronal plasticity and antidepressant actions

Castrén, E., & Hen, R. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.010 · Cited by 243 · see citing works

Long-Term Plasticity of Visually Evoked Potentials in Humans is Altered in Major Depression

Normann, C., Schmitz, D., Fürmaier, A., Döing, C., & Bach, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.006 · Cited by 243 · see citing works

Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking

Lepack, A. E., Werner, C. T., Stewart, A. F., Fulton, S. L., Zhong, P., Farrelly, L. A., Smith, A. C. W., Ramakrishnan, A., Lyu, Y., Bastle, R. M., et al. (2020) · Science · doi:10.1126/science.aaw8806 · Cited by 241 · see citing works

β-catenin mediates stress resilience through Dicer1/microRNA regulation

Dias, C., Feng, J., Sun, H., Shao, N. Y., Mazei-Robison, M. S., Damez-Werno, D., Scobie, K., Bagot, R., LaBonté, B., Ribeiro, E., et al. (2014) · Nature · doi:10.1038/nature13976 · Cited by 240 · see citing works

Data-driven biological subtypes of depression: Systematic review of biological approaches to depression subtyping

Beijers, L., Wardenaar, K. J., van Loo, H. M., & Schoevers, R. A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0385-5 · Cited by 240 · see citing works

Stress Activation of Cortex and Hippocampus Is Modulated by Sex and Stage of Estrus

Figueiredo, H. F., Dolgas, C. M., & Herman, J. P. (2002) · Endocrinology · doi:10.1210/endo.143.7.8888 · Cited by 237 · see citing works

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-Diol Inhibit the Hypothalamo–Pituitary–Adrenal Response to Stress by Acting through Estrogen Receptor β-Expressing Neurons in the Hypothalamus

Lund, T. D., Hinds, L. R., & Handa, R. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3777-05.2006 · Cited by 236 · see citing works

An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation

Kim, M.-S., Akhtar, M. W., Adachi, M., Mahgoub, M., Bassel-Duby, R., Kavalali, E. T., Olson, E. N., & Monteggia, L. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2089-12.2012 · Cited by 235 · see citing works

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

Cheung, I., Shulha, H. P., Jiang, Y., Matevossian, A., Wang, J., Weng, Z., & Akbarian, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001702107 · Cited by 235 · see citing works

Sex in the brain: hormones and sex differences

Marrocco, J., & McEwen, B. S. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/jmarrocco · Cited by 235 · see citing works

Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain

Lugli, G., Torvik, V. I., Larson, J., & Smalheiser, N. R. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05413.x · Cited by 228 · see citing works

Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner

Lugli, G., Larson, J., Martone, M. E., Jones, Y., & Smalheiser, N. R. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03224.x · Cited by 222 · see citing works

Epigenetic mechanisms of depression

Nestler, E. J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.4291 · Cited by 217 · see citing works

Sex differences in spatial and non-spatial Y-maze performance after chronic stress

Conrad, C. D., Grote, K. A., Hobbs, R. J., & Ferayorni, A. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(02)00018-7 · Cited by 215 · see citing works

Epigenetic Regulation in Human Brain—Focus on Histone Lysine Methylation

Akbarian, S., & Huang, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.015 · Cited by 214 · see citing works

17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females

Oberlander, J. G., & Woolley, C. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4437-15.2016 · Cited by 213 · see citing works

Reversal of hippocampal neuronal maturation by serotonergic antidepressants

Kobayashi, K., Ikeda, Y., Sakai, A., Yamasaki, N., Haneda, E., Miyakawa, T., & Suzuki, H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912690107 · Cited by 212 · see citing works

Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms

Kim, D. R., Bale, T. L., & Epperson, C. N. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-014-0546-9 · Cited by 203 · see citing works

Association of a history of child abuse with impaired myelination in the anterior cingulate cortex: convergent epigenetic, transcriptional, and morphological evidence

Lutz, P.-E., Tanti, A., Gasecka, A., Barnett-Burns, S., Kim, J. J., Zhou, Y., Chen, G. G., Wakid, M., Shaw, M., Almeida, D., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16111286 · Cited by 203 · see citing works

Disrupted Intricacy of Histone H3K4 Methylation in Neurodevelopmental Disorders

Vallianatos, C. N., & Iwase, S. (2015) · Epigenomics · doi:10.2217/epi.15.1 · Cited by 202 · see citing works

Sex differences in histone modifications in the neonatal mouse brain

Tsai, H., Grant, P. A., & Rissman, E. F. (2009) · Epigenetics · doi:10.4161/epi.4.1.7288 · Cited by 201 · see citing works

MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E. A., Vialou, V., Ku, S. M., Gerald, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15497 · Cited by 201 · see citing works

Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder

Roy, B., Dunbar, M., Shelton, R. C., & Dwivedi, Y. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.175 · Cited by 199 · see citing works

The Memory-Enhancing Effects of Hippocampal Estrogen Receptor Activation Involve Metabotropic Glutamate Receptor Signaling

Boulware, M. I., Heisler, J. D., & Frick, K. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1716-13.2013 · Cited by 196 · see citing works

Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and “depressed” mice exposed to chronic mild stress

Franceschelli, A., Sens, J. P., Herchick, S., Thelen, C., & Pitychoutis, P. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.008 · Cited by 195 · see citing works

Repeated estradiol administration alters different aspects of neurogenesis and cell death in the hippocampus of female, but not male, rats

Barker, J. M., & Galea, L. A. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.071 · Cited by 195 · see citing works

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

Chen, B., & Cepko, C. L. (2009) · Science · doi:10.1126/science.1166226 · Cited by 192 · see citing works

cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth

Chen, Z., Li, J., Lin, S., Cao, C., Gimbrone, N. T., Yang, R., Fu, D., Carper, M. B., Haura, E. B., Schabath, M. B., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85250 · Cited by 192 · see citing works

Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island

Philibert, R. A., Madan, A., Andersen, A. M., Cadoret, R. J., Packer, H., & Sandhu, H. K. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30414 · Cited by 191 · see citing works

Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons

Iwamoto, K., Bundo, M., Ueda, J., Oldham, M. C., Ukai, W., Hashimoto, E., Saito, T., Geschwind, D. H., & Kato, T. (2011) · Genome Research · doi:10.1101/gr.112755.110 · Cited by 189 · see citing works

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors

Cerniauskas, I., Winterer, J., de Jong, J. W., Lukacsovich, D., Yang, H., Khan, F., Peck, J. R., Obayashi, S. K., Lilascharoen, V., Lim, B. K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.005 · Cited by 187 · see citing works

Sex Differences in Epigenetic Regulation of the Estrogen Receptor-α Promoter within the Developing Preoptic Area

Kurian, J. R., Olesen, K. M., & Auger, A. P. (2010) · Endocrinology · doi:10.1210/en.2009-0649 · Cited by 185 · see citing works

Altered gene expression of histone deacetylases in mood disorder patients

Hobara, T., Uchida, S., Otsuki, K., Matsubara, T., Funato, H., Matsuo, K., Suetsugi, M., & Watanabe, Y. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.015 · Cited by 185 · see citing works

Identification of Differential MicroRNAs in Cerebrospinal Fluid and Serum of Patients with Major Depressive Disorder

Wan, Y., Liu, Y., Wang, X., Wu, J., Liu, K., Zhou, J., Liu, L., & Zhang, C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0121975 · Cited by 182 · see citing works

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works

Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression

Tadić, A., Müller-Engling, L., Schlicht, K. F., Kotsiari, A., Dreimüller, N., Kleimann, A., Bleich, S., Lieb, K., & Frieling, H. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.58 · Cited by 175 · see citing works

Cognitive dysfunction in major depression and bipolar disorder: <scp>A</scp>ssessment and treatment options

MacQueen, G. M., & Memedovich, K. A. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12463 · Cited by 172 · see citing works

Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment

Dworkin, A. M., Huang, T. H. ‐., & Toland, A. E. (2009) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2009.02.007 · Cited by 170 · see citing works

Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer’s Disease Adults

Cipriani, S., Ferrer, I., Aronica, E., Kovacs, G. G., Verney, C., Nardelli, J., Khung, S., Delezoide, A.-L., Milenkovic, I., Rasika, S., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy096 · Cited by 169 · see citing works

Regulation of histone H3K4 methylation in brain development and disease

Shen, E., Shulha, H. P., Weng, Z., & Akbarian, S. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0514 · Cited by 165 · see citing works

Altered expression of neurotrophic factors in patients with major depression

Otsuki, K., Uchida, S., Watanuki, T., Wakabayashi, Y., Fujimoto, M., Matsubara, T., Funato, H., & Watanabe, Y. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.010 · Cited by 162 · see citing works

The Role of Xist in X-Chromosome Dosage Compensation

Sahakyan, A., Yang, Y., & Plath, K. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.05.005 · Cited by 162 · see citing works

Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice

Higuchi, F., Uchida, S., Yamagata, H., Abe-Higuchi, N., Hobara, T., Hara, K., Kobayashi, A., Shintaku, T., Itoh, Y., Suzuki, T., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0319-16.2016 · Cited by 158 · see citing works

Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression

Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Wang, J., Tan, C., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Lorsch, Z. S., Hamilton, P. J., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.023 · Cited by 156 · see citing works

Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat

Sterrenburg, L., Gaszner, B., Boerrigter, J., Santbergen, L., Bramini, M., Elliott, E., Chen, A., Peeters, B. W. M. M., Roubos, E. W., & Kozicz, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028128 · Cited by 149 · see citing works

MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior

Allen, L., & Dwivedi, Y. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0597-8 · Cited by 148 · see citing works

Antidepressant‐like effect induced by systemic and intra‐hippocampal administration of DNA methylation inhibitors

Sales, A. J., Biojone, C., Terceti, M. S., Guimarães, F. S., Gomes, M. V., & Joca, S. R. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01489.x · Cited by 147 · see citing works

Large-Scale Population Study of Human Cell Lines Indicates that Dosage Compensation Is Virtually Complete

Johnston, C. M., Lovell, F. L., Leongamornlert, D. A., Stranger, B. E., Dermitzakis, E. T., & Ross, M. T. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040009 · Cited by 147 · see citing works

Beneficial effects of environmental enrichment on behavior, stress reactivity and synaptophysin/BDNF expression in hippocampus following early life stress

Dandi, Ε., Kalamari, A., Touloumi, O., Lagoudaki, R., Nousiopoulou, E., Simeonidou, C., Spandou, E., & Tata, D. Α. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.03.003 · Cited by 146 · see citing works

Sex, Stress, and Mood Disorders: At the Intersection of Adrenal and Gonadal Hormones

Fernández‐Guasti, A., Fiedler, J. L., Herrera, L., & Handa, R. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0032-1312592 · Cited by 143 · see citing works

Histone Deacetylation during Brain Development Is Essential for Permanent Masculinization of Sexual Behavior

Matsuda, K., Mori, H., Nugent, B. M., Pfaff, D. W., McCarthy, M. M., & Kawata, M. (2011) · Endocrinology · doi:10.1210/en.2011-0193 · Cited by 142 · see citing works

Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats: Epigenetics of serotonin-induced adult cortical plasticity

Vetencourt, J. F. M., Tiraboschi, E., Spolidoro, M., Castrén, E., & Maffei, L. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07488.x · Cited by 138 · see citing works

Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity

Maze, I. S., Noh, K., & Allis, C. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.124 · Cited by 136 · see citing works

SIRT1 gene is associated with major depressive disorder in the Japanese population

Kishi, T., Yoshimura, R., Kitajima, T., Okochi, T., Okumura, T., Tsunoka, T., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Fukuo, Y., et al. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.003 · Cited by 136 · see citing works

The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System

Cholewa-Waclaw, J., Bird, A. P., von Schimmelmann, M. J., Schaefer, A., Yu, H., Song, H., Madabhushi, R., & Tsai, L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2492-16.2016 · Cited by 132 · see citing works

Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders

Takebayashi, M., Hisaoka, K., Nishida, A., Okada‐Tsuchioka, M., Miyoshi, I., Kozuru, T., Hikasa, S., Okamoto, Y., Shinno, H., Morinobu, S., et al. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705006085 · Cited by 131 · see citing works

Altered sirtuin deacetylase gene expression in patients with a mood disorder

Abe, N., Uchida, S., Otsuki, K., Hobara, T., Yamagata, H., Higuchi, F., Shibata, T., & Watanabe, Y. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.016 · Cited by 131 · see citing works

Altered expression of neurotrophic factors in patients with major depression

大朏, 孝. (2008) · Medical Entomology and Zoology · Cited by 128 · see citing works

The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression

Okada, S., Morinobu, S., Fuchikami, M., Segawa, M., Yokomaku, K., Kataoka, T., Okamoto, Y., Yamawaki, S., Inoue, T., Kusumi, I., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.02.002 · Cited by 125 · see citing works

Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins

Sugawara, H., Iwamoto, K., Bundo, M., Ueda, J., Miyauchi, T., Komori, A., Kazuno, A., Adati, N., Kusumi, I., Okazaki, Y., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.26 · Cited by 121 · see citing works

Sex Differences in Synaptic Plasticity: Hormones and Beyond

Hyer, M. M., Phillips, L. L., & Neigh, G. N. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00266 · Cited by 121 · see citing works

The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134Preprint

Bicker, S., Khudayberdiev, S., Weiß, K., Zocher, K., Baumeister, S., & Schratt, G. M. (2013) · Genes & Development · doi:10.1101/gad.211243.112 · Cited by 118 · see citing works

miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression

Hu, Z., Yu, D., Gu, Q.-H., Yang, Y., Tu, K., Zhu, J., & Li, Z. (2014) · Nature Communications · doi:10.1038/ncomms4263 · Cited by 117 · see citing works

Estrogen protects against ??-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt

Zhang, L., Rubinow, D. R., Xaing, G.-Q., Li, B., Chang, Y. H., Maric, D., Barker, J. L., & Ma, W. (2001) · Neuroreport · doi:10.1097/00001756-200107030-00030 · Cited by 116 · see citing works

The genetics of depression: successful genome-wide association studies introduce new challenges

Ormel, J., Hartman, C. A., & Snieder, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0450-5 · Cited by 107 · see citing works

The opposite effects of stress on dendritic spines in male vs. female rats are NMDA receptor‐dependent

Shors, T. J., Falduto, J., & Leuner, B. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03065.x · Cited by 105 · see citing works

Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression

Iga, J.-I., Ueno, S.-I., Yamauchi, K., Numata, S., Kinouchi, S., Tayoshi-Shibuya, S., Song, H., & Ohmori, T. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.014 · Cited by 105 · see citing works

Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD

Maddox, S. A., Kilaru, V., Shin, J. H., Jovanović, T., Almli, L. M., Dias, B. G., Norrholm, S. D., Fani, N., Michopoulos, V., Ding, Z., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.250 · Cited by 104 · see citing works

microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus

O'Connor, R. M., Grenham, S., Dinan, T. G., & Cryan, J. F. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000448 · Cited by 101 · see citing works

Repression of Astrocytic Connexins in Cortical and Subcortical Brain Regions and Prefrontal Enrichment of H3K9me3 in Depression and Suicide

Nagy, C., Torres-Platas, S. G., Mechawar, N., & Turecki, G. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw071 · Cited by 98 · see citing works

Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder

Soeiro‐de‐Souza, M. G., Andreazza, A. C., Carvalho, A. F., Machado‐Vieira, R., Young, L. T., & Moreno, R. A. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000047 · Cited by 97 · see citing works

Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses

Zuloaga, D. G., Heck, A., Guzman, R. M. D., & Handa, R. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00319-2 · Cited by 96 · see citing works

Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder

He, S., Liu, X., Jiang, K., Peng, D., Hong, W., Fang, Y., Qian, Y., Yu, S., & Li, H. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.015 · Cited by 94 · see citing works

H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression

Cruceanu, C., Alda, M., Nagy, C., Freemantle, E., Rouleau, G. A., & Turecki, G. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000363 · Cited by 93 · see citing works

Estrogen Receptor (ER)β Isoforms Rather Than ERα Regulate Corticotropin-Releasing Hormone Promoter Activity through an Alternate Pathway

Miller, W. J. S., Suzuki, S., Miller, L. K., Handa, R. J., & Uht, R. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5540-03.2004 · Cited by 93 · see citing works

Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice

Shen, E., Ahern, T. H., Cheung, I. K., Straubhaar, J., Dincer, A., Houston, I. B., Vries, G. J. D., Akbarian, S., & Forger, N. G. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.08.006 · Cited by 91 · see citing works

Changes in miRNA-132 and miR-124 levels in non-treated and citalopram-treated patients with depression

Fang, Y., Qiu, Q., Zhang, S., Sun, L., Li, G., Xiao, S., & Li, X. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.090 · Cited by 90 · see citing works

Maternal Deprivation Enhances Behavioral Vulnerability to Stress Associated with miR-504 Expression in Nucleus Accumbens of Rats

Zhang, Y., Zhu, X., Bai, M., Zhang, L., Xue, L., & Yi, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069934 · Cited by 83 · see citing works

Non-Coding RNAs in Psychiatric Disorders and Suicidal Behavior

Yoshino, Y., & Dwivedi, Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.543893 · Cited by 82 · see citing works

Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse

Reinius, B., Shi, C., Hengshuo, L., Sandhu, K. S., Radomska, K. J., Rosen, G. D., Lu, L., Kullander, K., Williams, R. W., & JAZIN, E. E. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-614 · Cited by 81 · see citing works

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice

Li, H., Kawatake-Kuno, A., Inaba, H., Miyake, Y., Itoh, Y., Ueki, T., Oishi, N., Murai, T., Suzuki, T., & Uchida, S. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.004 · Cited by 31 · see citing works

Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons

Kawatake-Kuno, A., Li, H., Inaba, H., Hikosaka, M., Ishimori, E., Ueki, T., Garkun, Y., Morishita, H., Narumiya, S., Oishi, N., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.023 · Cited by 30 · see citing works

GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency

Inaba, H., Li, H., Kawatake-Kuno, A., Dewa, K., Nagai, J., Oishi, N., Murai, T., & Uchida, S. (2023) · Science Advances · doi:10.1126/sciadv.ade5397 · Cited by 30 · see citing works

A Multiscale View of the Mechanisms Underlying Ketamine’s Antidepressant Effects: An Update on Neuronal Calcium Signaling

Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.749180 · Cited by 26 · see citing works

Development and validation of a predictive model for depression in patients with advanced stage of cardiovascular-kidney-metabolic syndrome

Zha, B., Cai, A., Yu, H., & Wang, Z. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.04.139 · Cited by 17 · see citing works

Antidepressant Response and Stress Resilience Are Promoted by CART Peptides in GABAergic Neurons of the Anterior Cingulate Cortex

Funayama, Y., Li, H., Ishimori, E., Kawatake-Kuno, A., Inaba, H., Yamagata, H., Seki, T., Nakagawa, S., Watanabe, Y., Murai, T., et al. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.12.009 · Cited by 16 · see citing works

COVID-19-related stigma and its relationship with mental wellbeing: A cross-sectional analysis of a cohort study in Japan

Sawaguchi, E., Nakamura, S., Watanabe, K., Tsuno, K., Ikegami, H., Shinmura, N., Saito, Y., & Narimatsu, H. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1010720 · Cited by 16 · see citing works

Sex Significantly Impacts the Function of Major Depression–Linked Variants In Vivo

Mulvey, B., Selmanovic, D., & Dougherty, J. D. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.02.009 · Cited by 12 · see citing works

Identification of Specific Plasma miRNAs as Potential Biomarkers for Major Depressive Disorder

Prodan-Bărbulescu, C., Alin, C. D., Faur, F. I., Bujor, G. C., Șeclăman, E. P., ENĂTESCU, V. R., Dănilă, A.-I., Dăescu, E., Hajjar, R., Ghenciu, L. A., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12102165 · Cited by 6 · see citing works

Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook

Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7 · see citing works

Schisandrin C alleviates depressive-like behaviors by modulating the AKT/CREB/BDNF pathway, the serotonin pathway of tryptophan metabolism, and the gut microbiota composition

Tran, S. H., Zhang, S., Lee, H., Hitayezu, E., Nguyen, U. T. T., Lee, S., Kang, S. W., Park, K., Kim, S. H., Kwon, H. C., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157581 · Cited by 4 · see citing works

Depression: epigenetics and epitranscriptomic modifications

Banerjee, S., Shrilaxmi, M. S., Banerjee, S., Prajwal, B. G., Smith, C., D’Mello, S. R., & Dastidar, S. G. (2025) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2025.2602171 · Cited by 4 · see citing works

Negative life events and depression by gender in the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil)

da Silva, S. V., Santos, I. S., Bivanco-Lima, D., Goulart, A. C., Varella, A. C., Lotufo, P. A., Brunoni, A. R., & Benseñor, I. M. (2024) · Clinics · doi:10.1016/j.clinsp.2024.100488 · Cited by 1 · see citing works

Depression and Cancer: The Inflammatory Bridge

Leite, F., & Leite, Â. M. T. (2023) · Interdisciplinary cancer research · doi:10.1007/16833_2022_106 · Cited by 1 · see citing works

Integrating weighted gene co-expression network analysis and machine learning to elucidate neural characteristics in a mouse model of depression

Gao, J., Wang, Q., Liu, J., Zheng, S., Liu, J., Gao, Z., & Zhu, C. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1564095 · Cited by 1 · see citing works

Sex significantly impacts the function of major depression-linked variants in vivoPreprint

Mulvey, B., Selmanovic, D., & Dougherty, J. D. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.01.466849 · Cited by 1 · see citing works

Eventos negativos de vida e a relação com depressão: análise transversal e prospectiva do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil)

da Silva, S. V. (2024) · doi:10.11606/d.5.2024.tde-03122024-125357

Sex differences in brain network functional connectivity and their association with gene expression profiles in major depressive disorder: a REST-meta-MDD project-based study

Jiang, W., Chen, C., Wang, S., Liu, Y., Li, P., & Zhang, B. (2025) · Brain Imaging and Behavior · doi:10.1007/s11682-025-01062-1

Distinct prefrontal neuronal circuits determine repeated stress-induced behavioral styles in mice

Uchida, S. (2026) · Folia Pharmacologica Japonica · doi:10.1254/fpj.25040

Dyssomnias Are Linked to Impaired Ventilatory Function in Young Athletes Regardless of Sex: A Cross-Sectional Study

Corral-Castillo, D. A., Blanco-Salazar, A., Garcia-Murillo, O. G., Ruiz-Olvera, A., Hernández-Lepe, M. A., Llamas-Alonso, L. A., Amaro‐Gahete, F. J., Egan, B., & Chávez-Guevara, I. A. (2026) · Translational Journal of the American College of Sports Medicine · doi:10.1249/tjx.0000000000000345

Comparative evaluation of two chronic stress models in zebrafish for advancing depression research

Tripathy, C., Dhaygude, S. S., Vijay, V., Mondal, A., Soren, K., Kumar, A. T. R., & Chakravarty, S. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115453

Understanding the epigenetic basis of sex differences in depression

Hodes, G. E., Walker, D. M., Labonté, B., Nestler, E. J., & Russo, S. J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23876 · Cited by 82 · see citing works

Epigenetic dysregulation in depression: molecular mechanisms, clinical biomarkers, and therapeutic opportunities

Li, J., Guan, X., Zhang, R., & Zhang, H. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08772-0

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works

Molecular programs underlying differences in the expression of mood disorders in males and females

Mena, F., & Benoit, L. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.016 · Cited by 9 · see citing works

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works