The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
An in Vivo Map of the Yeast Protein Interactome
Abstract
Protein interactions regulate the systems-level behavior of cells; thus, deciphering the structure and dynamics of protein interaction networks in their cellular context is a central goal in biology. We have performed a genome-wide in vivo screen for protein-protein interactions in Saccharomyces cerevisiae by means of a protein-fragment complementation assay (PCA). We identified 2770 interactions among 1124 endogenously expressed proteins. Comparison with previous studies confirmed known interactions, but most were not known, revealing a previously unexplored subspace of the yeast protein interactome. The PCA detected structural and topological relationships between proteins, providing an 8-nanometer–resolution map of dynamically interacting complexes in vivo and extended networks that provide insights into fundamental cellular processes, including cell polarization and autophagy, pathways that are evolutionarily conserved and central to both development and human health.
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A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., Lockshon, D., Narayan, V., Srinivasan, M., Pochart, P., et al. (2000) · Nature · doi:10.1038/35001009 · Cited by 4,706
A comprehensive two-hybrid analysis to explore the yeast protein interactome
Ito, T., Chiba, T., Ozawa, R., Yoshida, M., Hattori, M., & Sakaki, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061034498 · Cited by 3,566
Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae
Collins, S. R., Kemmeren, P., Zhao, X.-C., Greenblatt, J. F., Spencer, F., Holstege, F. C. P., Weissman, J. S., & Krogan, N. J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600381-mcp200 · Cited by 795
Why Are There Still Over 1000 Uncharacterized Yeast Genes?
Peña-Castillo, L., & Hughes, T. R. (2007) · Genetics · doi:10.1534/genetics.107.074468 · Cited by 161
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Metadata
- Authors
- Tarassov, K., Messier, V., Landry, C. R., Radinovic, S., Molina, M. M. S., Shames, I., Malitskaya, Y., Vogel, J., Bussey, H., & Michnick, S. W.
- Venue
- Science
- Published
- 2008-06-13
- Volume
- 320
- Issue
- 5882
- Pages
- 1465-1470
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006124679
- Cited by
- 774
- References
- 4
- FWCI
- 28.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tarassov, K., Messier, V., Landry, C. R., Radinovic, S., Molina, M. M. S., Shames, I., Malitskaya, Y., Vogel, J., Bussey, H., & Michnick, S. W. (2008). An in Vivo Map of the Yeast Protein Interactome. Science. https://doi.org/10.1126/science.1153878
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