The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Plant Immunity Requires Conformational Charges of NPR1 via S-Nitrosylation and Thioredoxins
Open accessAbstract
Changes in redox status have been observed during immune responses in different organisms, but the associated signaling mechanisms are poorly understood. In plants, these redox changes regulate the conformation of NPR1, a master regulator of salicylic acid (SA)–mediated defense genes. NPR1 is sequestered in the cytoplasm as an oligomer through intermolecular disulfide bonds. We report that S-nitrosylation of NPR1 by S- nitrosoglutathione (GSNO) at cysteine-156 facilitates its oligomerization, which maintains protein homeostasis upon SA induction. Conversely, the SA-induced NPR1 oligomer-to-monomer reaction is catalyzed by thioredoxins (TRXs). Mutations in both NPR1 cysteine-156 and TRX compromised NPR1-mediated disease resistance. Thus, the regulation of NPR1 is through the opposing action of GSNO and TRX. These findings suggest a link between pathogen-triggered redox changes and gene regulation in plant immunity.
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Cites
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Protein S-nitrosylation: Purview and parameters
Hess, D. T., Matsumoto, A., Kim, S.-O., Marshall, H. E., & Stamler, J. S. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1569 · Cited by 2,153
Arnelle, D. R., & Stamler, J. S. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1231 · Cited by 604
Cited by
Salicylic acid, a multifaceted hormone to combat disease
Vlot, A. C., Dempsey, D. A., & Klessig, D. F. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.050908.135202 · Cited by 2,568
Allicin: Chemistry and biological properties
Borlinghaus, J., Albrecht, F., Gruhlke, M., Nwachukwu, I., & Slusarenko, A. (2014) · Molecules · doi:10.3390/molecules190812591 · Cited by 893
Protein denitrosylation: enzymatic mechanisms and cellular functions
Benhar, M., Forrester, M. T., & Stamler, J. S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2764 · Cited by 522
Salicylic Acid and its Function in Plant ImmunityF
An, C., & Mou, Z. (2011) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2011.01043.x · Cited by 517
Self-citationIntervention of Phytohormone Pathways by Pathogen Effectors
Kazan, K., & Lyons, R. (2014) · The Plant Cell · doi:10.1105/tpc.114.125419 · Cited by 488
Metadata
- Authors
- Tada, Y., Spoel, S. H., Pajerowska-Mukhtar, K., Mou, Z., Song, J., Wang, C., Zuo, J., & Dong, X.
- Venue
- Science
- Published
- 2008-08-15
- Volume
- 321
- Issue
- 5891
- Pages
- 952-956
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2168969893
- Cited by
- 1,128
- References
- 3
- FWCI
- 65.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Tada, Y., Spoel, S. H., Pajerowska-Mukhtar, K., Mou, Z., Song, J., Wang, C., Zuo, J., & Dong, X. (2008). Plant Immunity Requires Conformational Charges of NPR1 via S-Nitrosylation and Thioredoxins. Science. https://doi.org/10.1126/science.1156970
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