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Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry
Open accessAbstract
A central question in the study of cell proliferation is, what controls cell-cycle transitions? Although the accumulation of mitotic cyclins drives the transition from the G 2 phase to the M phase in embryonic cells, the trigger for mitotic entry in somatic cells remains unknown. We report that the synergistic action of Bora and the kinase Aurora A (Aur-A) controls the G 2 -M transition. Bora accumulates in the G 2 phase and promotes Aur-A–mediated activation of Polo-like kinase 1 (Plk1), leading to the activation of cyclin-dependent kinase 1 and mitotic entry. Mechanistically, Bora interacts with Plk1 and controls the accessibility of its activation loop for phosphorylation and activation by Aur-A. Thus, Bora and Aur-A control mitotic entry, which provides a mechanism for one of the most important yet ill-defined events in the cell cycle.
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Cited by
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Exploiting senescence for the treatment of cancer
Wang, L., Lankhorst, L., & Bernards, R. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-022-00450-9 · Cited by 867
Shared and separate functions of polo-like kinases and aurora kinases in cancer
Lens, S. M. A., Voest, E. E., & Medema, R. H. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2964 · Cited by 597
Aurora A kinase (AURKA) in normal and pathological cell division
Nikonova, A. S., Astsaturov, I., Serebriiskii, I. G., Dunbrack, R. L., & Golemis, E. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1073-7 · Cited by 448
The Aurora kinase family in cell division and cancer
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Metadata
- Authors
- Seki, A., Coppinger, J. A., Jang, C.-Y., Yates, J. R., & Fang, G.
- Venue
- Science
- Published
- 2008-06-20
- Volume
- 320
- Issue
- 5883
- Pages
- 1655-1658
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059706603
- Cited by
- 619
- References
- 0
- FWCI
- 14.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Seki, A., Coppinger, J. A., Jang, C.-Y., Yates, J. R., & Fang, G. (2008). Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry. Science. https://doi.org/10.1126/science.1157425
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