Exploiting senescence for the treatment of cancer

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Cellular Senescence: Defining a Path Forward

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Aging, Cellular Senescence, and Cancer

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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Cellular senescence: from physiology to pathology

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Hallmarks of Cellular Senescence

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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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Cellular senescence in aging and age-related disease: from mechanisms to therapy

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Topoisomerase I inhibitors: camptothecins and beyond

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Senolytics improve physical function and increase lifespan in old age

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

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The Interleukin-8 Pathway in Cancer

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Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

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The essence of senescence: Figure 1.

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Senescence of activated stellate cells limits liver fibrosis

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Senescence of Activated Stellate Cells Limits Liver Fibrosis

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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The first 30 years of p53: growing ever more complex.

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An Oncogene-Induced DNA Damage Model for Cancer Development

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Restoration of p53 function leads to tumour regression in vivo

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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Targeting DNA topoisomerase II in cancer chemotherapy

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Chemokine signaling via the CXCR2 receptor reinforces senescence

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Senescence in Health and Disease

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

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DNA Damage Sensing by the ATM and ATR Kinases

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CDK4/6 inhibition triggers anti-tumour immunity

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Senescence in premalignant tumours

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

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Senescence-associated β-galactosidase is lysosomal β-galactosidase.

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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

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Angiogenesis and Inflammation in Peritoneal Dialysis: The Role of Adipocytes

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A proteomic atlas of senescence-associated secretomes for aging biomarker development

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Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

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Senescent cells: an emerging target for diseases of ageing

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Induction of Apoptosis by Cancer Chemotherapy

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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

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Senolytic drugs: from discovery to translation

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Oncogene-induced senescence as an initial barrier in lymphoma development

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

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Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

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Senescence-associated reprogramming promotes cancer stemness

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Senescence in tumours: evidence from mice and humans

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Forging a signature of in vivo senescence

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Senolytic CAR T cells reverse senescence-associated pathologies

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A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

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Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

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Fisetin is a senotherapeutic that extends health and lifespan

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Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

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cGAS is essential for cellular senescence

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Regulation of p53 in response to DNA damage

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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

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The rediscovery of platinum-based cancer therapy

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Unmasking Transcriptional Heterogeneity in Senescent Cells

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An aged immune system drives senescence and ageing of solid organs

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Unmasking senescence: context-dependent effects of SASP in cancer

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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

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CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

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Non-Cell-Autonomous Tumor Suppression by p53

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T-helper-1-cell cytokines drive cancer into senescence

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