The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
An Argonaute Transports siRNAs from the Cytoplasm to the Nucleus
Open accessAbstract
Ribonucleoprotein complexes consisting of Argonaute-like proteins and small regulatory RNAs function in a wide range of biological processes. Many of these small regulatory RNAs are predicted to act, at least in part, within the nucleus. We conducted a genetic screen to identify factors essential for RNA interference (RNAi) in nuclei of Caenorhabditis elegans and identified the Argonaute protein NRDE-3. In the absence of small interfering RNAs (siRNAs), NRDE-3 resides in the cytoplasm. NRDE-3 binds siRNAs generated by RNA-dependent RNA polymerases acting on messenger RNA templates in the cytoplasm and redistributes to the nucleus. Nuclear redistribution of NRDE-3 requires a functional nuclear localization signal, is required for nuclear RNAi, and results in NRDE-3 association with nuclear-localized nascent transcripts. Thus, specific Argonaute proteins can transport specific classes of small regulatory RNAs to distinct cellular compartments to regulate gene expression.
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1 retracted
RETRACTED: Secondary siRNAs Result from Unprimed RNA Synthesis and Form a Distinct Class
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RetractedRegulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
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Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity
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MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline
Carmell, M. A., Girard, A., van de Kant, H. J. G., Bourc'his, D., Bestor, T. H., de Rooij, D. G., & Hannon, G. J. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.001 · Cited by 1,147
Establishment and Maintenance of a Heterochromatin Domain
Hall, I. M., Shankaranarayana, G. D., Noma, K.-I., Ayoub, N., Cohen, A., & Grewal, S. I. S. (2002) · Science · doi:10.1126/science.1076466 · Cited by 895
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
Ma, J.-B., Ye, K., & Patel, D. J. (2004) · Nature · doi:10.1038/nature02519 · Cited by 732
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Analysis of a piwi-Related Gene Implicates Small RNAs in Genome Rearrangement in Tetrahymena
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Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans
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A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
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Perez, M. F., & Lehner, B. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0242-9 · Cited by 528
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Wan, G., Fields, B. D., Spracklin, G., Shukla, A., Phillips, C. M., & Kennedy, S. (2018) · Nature · doi:10.1038/s41586-018-0132-0 · Cited by 207
Self-citationTruesdell, S. S., Mortensen, R. D., Seo, M., Schroeder, J. C., Lee, J. H., LeTonqueze, O., & Vasudevan, S. (2012) · Scientific Reports · doi:10.1038/srep00842 · Cited by 173
Direct transcriptional regulation by nuclear microRNAs
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Metadata
- Authors
- Guang, S., Bochner, A. F., Pavelec, D. M., Burkhart, K. B., Harding, S., Lachowiec, J., & Kennedy, S.
- Venue
- Science
- Published
- 2008-07-25
- Volume
- 321
- Issue
- 5888
- Pages
- 537-541
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027891004
- Cited by
- 351
- References
- 18
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- green
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