Cited by 78MicroRNA in disease regulationPlant Molecular Biology ResearchRNA Interference and Gene Delivery

Direct transcriptional regulation by nuclear microRNAs

Salmanidis, Marika, Pillman, Katherine, Goodall, Gregory, Bracken, Cameron·2014·The International Journal of Biochemistry & Cell Biology

Abstract

The function of microRNAs is well characterized in the cytoplasm, where they direct an Argonaute-containing complex to target and repress mRNAs. More recently, regulatory roles for microRNAs and Argonaute have also been reported in the nucleus where microRNAs guide Argonaute to target gene promoters and directly regulate transcription in either a positive or a negative manner. Deep sequencing has revealed a high abundance of endogenous microRNAs within the nucleus, and in silico target prediction suggests thousands of potential microRNA:promoter interaction sites. The predicted high frequency of miRNA:promoter interactions is supported by chromatin immunoprecipitation, indicating the microRNA-dependent recruitment of Argonaute to thousands of transcriptional start sites and the subsequent regulation of RNA polymerase-II occupancy and chromatin modifiers. In this review we discuss the evidence for, and mechanisms associated with, direct transcriptional regulation by microRNAs which may represent a significant and largely unexplored aspect of microRNA function. This article is part of a Directed Issue entitled: The non-coding RNA revolution.

Integrity signals

Registry

Crossref · 10.1016/j.biocel.2014.03.010

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Salmanidis, M., Pillman, K., Goodall, G., & Bracken, C.
Affiliations
University of South Australia (AU)
Corresponding author
Bracken, Cameron
Venue
The International Journal of Biochemistry & Cell Biology
Publisher
Elsevier BV
Published
2014-09
Volume
54
Pages
304-311
ISSN
1357-2725 (ISSN-L)
OpenAlex
W1990243228
Cited by
78
References
92
Citations by year
2026: 1 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 12
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Locations
  • The International Journal of Biochemistry & Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders
  • National Health and Medical Research Council
  • Association for International Cancer Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
transcriptional regulation, Argonaute proteins, RNA polymerase II, chromatin modification, non-coding RNA, endogenous microRNAs, transcription start sites
MeSH terms
Animals, Cell Nucleus, Gene Expression Regulation, Humans, Promoter Regions, Genetic, RNA, Messenger, Transcription, Genetic, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review