Direct transcriptional regulation by nuclear microRNAs
Abstract
The function of microRNAs is well characterized in the cytoplasm, where they direct an Argonaute-containing complex to target and repress mRNAs. More recently, regulatory roles for microRNAs and Argonaute have also been reported in the nucleus where microRNAs guide Argonaute to target gene promoters and directly regulate transcription in either a positive or a negative manner. Deep sequencing has revealed a high abundance of endogenous microRNAs within the nucleus, and in silico target prediction suggests thousands of potential microRNA:promoter interaction sites. The predicted high frequency of miRNA:promoter interactions is supported by chromatin immunoprecipitation, indicating the microRNA-dependent recruitment of Argonaute to thousands of transcriptional start sites and the subsequent regulation of RNA polymerase-II occupancy and chromatin modifiers. In this review we discuss the evidence for, and mechanisms associated with, direct transcriptional regulation by microRNAs which may represent a significant and largely unexplored aspect of microRNA function. This article is part of a Directed Issue entitled: The non-coding RNA revolution.
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Dysregulation of ciRS-7 has been found in zebrafish with an impaired midbrain and in the hippocampus of AD patients.
“In addition, dysregulation of ciRS-7 has been found in zebrafish with an impaired midbrain [71] and in the hippocampus of AD patients [45].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [71]
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RNA Activation in Plants: Current Evidence and Molecular Insights
Dubrovina, A. S., & Kiselev, K. V. (2026) · Plants · doi:10.3390/plants15192956
- Authors
- Salmanidis, M., Pillman, K., Goodall, G., & Bracken, C.
- Affiliations
- University of South Australia (AU)
- Corresponding author
- Bracken, Cameron
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 54
- Pages
- 304-311
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W1990243228
- Cited by
- 78
- References
- 92
- Citations by year
- 2026: 1 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 12
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- National Health and Medical Research Council
- Association for International Cancer Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- transcriptional regulation, Argonaute proteins, RNA polymerase II, chromatin modification, non-coding RNA, endogenous microRNAs, transcription start sites
- MeSH terms
- Animals, Cell Nucleus, Gene Expression Regulation, Humans, Promoter Regions, Genetic, RNA, Messenger, Transcription, Genetic, MicroRNAs
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