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Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP
Open accessAbstract
Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression. However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a mystery. We found that cyclic di-GMP in many bacterial species is sensed by a riboswitch class in messenger RNA that controls the expression of genes involved in numerous fundamental cellular processes. A variety of cyclic di-GMP regulons are revealed, including some riboswitches associated with virulence gene expression, pilus formation, and flagellum biosynthesis. In addition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of a bacteriophage.
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Metadata
- Authors
- Sudarsan, N., Lee, E. R., Weinberg, Z., Moy, R. H., Kim, J. N., Link, K. H., & Breaker, R. R.
- Venue
- Science
- Published
- 2008-07-18
- Volume
- 321
- Issue
- 5887
- Pages
- 411-413
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048706341
- Cited by
- 719
- References
- 0
- FWCI
- 19.98
- Type
- journal article
- Language
- en
- Open access
- green
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