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The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na + /Sugar Symport
Open accessAbstract
Membrane transporters that use energy stored in sodium gradients to drive nutrients into cells constitute a major class of proteins. We report the crystal structure of a member of the solute sodium symporters (SSS), the Vibrio parahaemolyticus sodium/galactose symporter (vSGLT). The ∼3.0 angstrom structure contains 14 transmembrane (TM) helices in an inward-facing conformation with a core structure of inverted repeats of 5 TM helices (TM2 to TM6 and TM7 to TM11). Galactose is bound in the center of the core, occluded from the outside solutions by hydrophobic residues. Surprisingly, the architecture of the core is similar to that of the leucine transporter (LeuT) from a different gene family. Modeling the outward-facing conformation based on the LeuT structure, in conjunction with biophysical data, provides insight into structural rearrangements for active transport.
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Cited by
Biology of Human Sodium Glucose Transporters
Wright, E. M., Loo, D. D. F., & Hirayama, B. A. (2011) · Physiological Reviews · doi:10.1152/physrev.00055.2009 · Cited by 1,430
Self-citationChen, L.-Q., Cheung, L. S., Feng, L., Tanner, W., & Frommer, W. B. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033904 · Cited by 507
Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences
Gallo, L. A., Wright, E. M., & Vallon, V. (2015) · Diabetes and Vascular Disease Research · doi:10.1177/1479164114561992 · Cited by 395
Self-citationA Molecular Description of Cellulose Biosynthesis
McNamara, J. T., Morgan, J. L. W., & Zimmer, J. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033930 · Cited by 382
Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2
Ghezzi, C., Loo, D. D. F., & Wright, E. M. (2018) · Diabetologia · doi:10.1007/s00125-018-4656-5 · Cited by 348
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Metadata
- Authors
- Faham, S., Watanabe, A., Besserer, G. M., Cascio, D., Specht, A., Hirayama, B. A., Wright, E. M., & Abramson, J.
- Venue
- Science
- Published
- 2008-08-08
- Volume
- 321
- Issue
- 5890
- Pages
- 810-814
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049519918
- Cited by
- 522
- References
- 0
- FWCI
- 25.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Faham, S., Watanabe, A., Besserer, G. M., Cascio, D., Specht, A., Hirayama, B. A., Wright, E. M., & Abramson, J. (2008). The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na + /Sugar Symport. Science. https://doi.org/10.1126/science.1160406
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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