Transport of Sugars

Sugar transporters for intercellular exchange and nutrition of pathogens

Chen, L., Hou, B., Lalonde, S., Takanaga, H., Hartung, M. L., Qu, X.-Q., Guo, W., Kim, J., Underwood, W. R., Chaudhuri, B., et al. (2010) · Nature · doi:10.1038/nature09606 · Cited by 1,629 · see citing works

Sequence and Structure of a Human Glucose Transporter

Mueckler, M. M., Caruso, C., Baldwin, S. A., Panico, M., Blench, I., Morris, H. R., Allard, W. J., Lienhard, G. E., & Lodish, H. F. (1985) · Science · doi:10.1126/science.3839598 · Cited by 1,529 · see citing works

Biology of Human Sodium Glucose Transporters

Wright, E. M., Loo, D. D. F., & Hirayama, B. A. (2011) · Physiological Reviews · doi:10.1152/physrev.00055.2009 · Cited by 1,430 · see citing works

Structure and Mechanism of the Lactose Permease of Escherichia coli

Abramson, J., Smirnova, I., Kasho, V. N., Verner, G., Kaback, H. R., & Iwata, S. (2003) · Science · doi:10.1126/science.1088196 · Cited by 1,389 · see citing works

Sucrose Efflux Mediated by SWEET Proteins as a Key Step for Phloem Transport

Chen, L., Qu, X.-Q., Hou, B., Sosso, D., Osorio, S., Fernie, A. R., & Frommer, W. B. (2011) · Science · doi:10.1126/science.1213351 · Cited by 1,384 · see citing works

The SLC2 (GLUT) family of membrane transporters

Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328 · see citing works

Regulated transport of the glucose transporter GLUT4

Bryant, N. J., Govers, R., & James, D. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm782 · Cited by 1,183 · see citing works

Coupled transport of sodium and organic solutes.

Schultz, S. G., & Curran, P. F. (1970) · Physiological Reviews · doi:10.1152/physrev.1970.50.4.637 · Cited by 1,175 · see citing works

Glucose transporters in the 21st Century

Thorens, B., & Mueckler, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00712.2009 · Cited by 1,013 · see citing works

Expression cloning and cDNA sequencing of the Na+/glucose co-transporter

Hediger, M. A., Coady, M. J., Ikeda, T. S., & Wright, E. M. (1987) · Nature · doi:10.1038/330379a0 · Cited by 1,004 · see citing works

Structure of a Glycerol-Conducting Channel and the Basis for Its Selectivity

Fu, D., Libson, A. M., Miercke, L. J. W., Weitzman, C., Nollert, P., Krucinski, J., & Stroud, R. M. (2000) · Science · doi:10.1126/science.290.5491.481 · Cited by 1,000 · see citing works

Mutation in hepatocyte nuclear factor–1β gene (TCF2) associated with MODY

Horikawa, Y., Iwasaki, N., Hara, M., Furuta, H., Hinokio, Y., Cockburn, B. N., Lindner, T. H., Yamagata, K., Ogata, M., Tomonaga, O., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-384 · Cited by 878 · see citing works

Crystal structure of the human glucose transporter GLUT1

Deng, D., Xu, C., Sun, P., Wu, J., Yan, C., Hu, M., & Yan, N. (2014) · Nature · doi:10.1038/nature13306 · Cited by 777 · see citing works

Na+-<scp>d</scp>-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

Gorboulev, V., Schürmann, A., Vallon, V., Kipp, H., Jaschke, A., Klessen, D., Friedrich, A., Scherneck, S., Rieg, T., Cunard, R., et al. (2012) · Diabetes · doi:10.2337/db11-1029 · Cited by 687 · see citing works

Os8N3 is a host disease-susceptibility gene for bacterial blight of rice

Yang, B., Sugio, A., & White, F. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604088103 · Cited by 635 · see citing works

A common mechanism of action for three mood-stabilizing drugs

Williams, R. S. B., Cheng, L., Mudge, A. W., & Harwood, A. J. (2002) · Nature · doi:10.1038/417292a · Cited by 617 · see citing works

PHOSPHATE BOUND TO HISTIDINE IN A PROTEIN AS AN INTERMEDIATE IN A NOVEL PHOSPHO-TRANSFERASE SYSTEM

Kundig, W., Ghosh, S., & Roseman, S. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.52.4.1067 · Cited by 616 · see citing works

SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule

Vallon, V., Platt, K. A., Cunard, R. A., Schroth, J., Whaley, J. M., Thomson, S. C., Koepsell, H., & Rieg, T. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010030246 · Cited by 565 · see citing works

Fructose transporter in human spermatozoa and small intestine is GLUT5.

Burant, C., Takeda, J., Brot‐Laroche, E., Bell, G. I., & Davidson, N. O. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42067-4 · Cited by 545 · see citing works

The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na + /Sugar Symport

Faham, S., Watanabe, A., Mercado, G., Cascio, D., Specht, A., Hirayama, B. A., Wright, E. M., & Abramson, J. (2008) · Science · doi:10.1126/science.1160406 · Cited by 522 · see citing works

Crystal structure of a catalytic intermediate of the maltose transporter

Oldham, M. L., Khare, D., Quiocho, F. A., Davidson, A. L., & Chen, J. (2007) · Nature · doi:10.1038/nature06264 · Cited by 508 · see citing works

Isolation and characterization of a sucrose carrier cDNA from spinach by functional expression in yeast.

Riesmeier, J. W., Willmitzer, L., & Frommer, W. B. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05575.x · Cited by 504 · see citing works

Sequence of the lactose permease gene

Büchel, D. E., Gronenborn, B., & Müller‐Hill, B. (1980) · Nature · doi:10.1038/283541a0 · Cited by 500 · see citing works

NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds

Nour‐Eldin, H. H., Andersen, T. G., Burow, M., Madsen, S. R., Jørgensen, M. E., Olsen, C. E., Drèyer, I., Hedrich, R., Geiger, D., & Halkier, B. A. (2012) · Nature · doi:10.1038/nature11285 · Cited by 487 · see citing works

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

Sun, L., Zeng, X. W., Yan, C., Sun, X., Gong, X., Rao, Y., & Yan, N. (2012) · Nature · doi:10.1038/nature11524 · Cited by 472 · see citing works

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

Katz, E. B., Stenbit, A. E., Hatton, K. S., DePinho, R. A., & Charron, M. J. (1995) · Nature · doi:10.1038/377151a0 · Cited by 467 · see citing works

TRANSPORT MECHANISMS FOR ORGANIC FORMS OF CARBON AND NITROGEN BETWEEN SOURCE AND SINK

Lalonde, S., Wipf, D., & Frommer, W. B. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141758 · Cited by 463 · see citing works

Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia

Wallace, C., Newhouse, S., Braund, P. S., Zhang, F., Tobin, M. D., Falchi, M., Ahmadi, K. R., Dobson, R., Marçano, A. C. B., Hajat, C., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.11.001 · Cited by 437 · see citing works

A Cascade of Sequentially Expressed Sucrose Transporters in the Seed Coat and Endosperm Provides Nutrition for the Arabidopsis Embryo

Chen, L., Lin, I. W., Qu, X.-Q., Sosso, D., McFarlane, H. E., Londoño, A., Samuels, L., & Frommer, W. B. (2015) · The Plant Cell · doi:10.1105/tpc.114.134585 · Cited by 437 · see citing works

The Bacterial Phosphoenolpyruvate:Carbohydrate Phosphotransferase System: Regulation by Protein Phosphorylation and Phosphorylation-Dependent Protein-Protein Interactions

Deutscher, J., Aké, F. M., Derkaoui, M., Zébré, A. C., Cao, T. N., Bouraoui, H., Kentache, T., Mokhtari, A., Milohanic, E., & Joyet, P. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00001-14 · Cited by 432 · see citing works

Nectar secretion requires sucrose phosphate synthases and the sugar transporter SWEET9

Lin, I. W., Sosso, D., Chen, L., Gase, K., Kim, S.-G., Kessler, D., Klinkenberg, P. M., Gorder, M. K., Hou, B., Qu, X.-Q., et al. (2014) · Nature · doi:10.1038/nature13082 · Cited by 431 · see citing works

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

Guillam, M., Hümmler, E., Schaerer, E., Wu, J.-Y., Birnbaum, M. J., Beermann, F., Schmidt, A., Dériaz, N., & Thorens, B. (1997) · Nature Genetics · doi:10.1038/ng1197-327 · Cited by 430 · see citing works

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

De Vos, A., Heimberg, H., Quartier, E., Huypens, P., Bouwens, L., Pipeleers, D., & Schuit, F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118308 · Cited by 425 · see citing works

Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression.

Özcan, S., Dover, J., Rosenwald, A., Wölfl, S., & Johnston, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12428 · Cited by 420 · see citing works

The Role of Energy Coupling in the Transport of β-Galactosides by Escherichia coli

Winkler, H. H., & Wilson, T. H. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96607-x · Cited by 413 · see citing works

Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome

Coucke, P. J., Willaert, A., Wessels, M. W., Callewaert, B. L., Zoppi, N., Backer, J. F. A. D., Fox, J. E., Mancini, G. M. S., Kambouris, M., Gardella, R., et al. (2006) · Nature Genetics · doi:10.1038/ng1764 · Cited by 399 · see citing works

The protein family of glucose transport facilitators: It's not only about glucose after all

Augustin, R. (2010) · IUBMB Life · doi:10.1002/iub.315 · Cited by 398 · see citing works

Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).

Kayano, T., Burant, C., Fukumoto, H., Gould, G. W., Fan, Y. S., Eddy, R. L., Byers, M. G., Shows, T. B., Seino, S., & Bell, G. I. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38295-x · Cited by 389 · see citing works

Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter

Turk, E., Zabel, B., Mundlos, S., Dyer, J., & Wright, E. M. (1991) · Nature · doi:10.1038/350354a0 · Cited by 379 · see citing works

Kinetic Characterization of Individual Hexose Transporters of Saccharomyces Cerevisiae and their Relation to the Triggering Mechanisms of Glucose Repression

Reifenberger, E., Boles, E., & Ciriacy, M. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00324.x · Cited by 376 · see citing works

Inhibition of water and solute permeability in human red cells

Macey, R. L., & Farmer, R. E. L. (1970) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(70)90130-6 · Cited by 373 · see citing works

Specific labeling and partial purification of the M protein, a component of the beta-galactoside transport system of Escherichia coli.

Fox, C., & Kennedy, E. P. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.3.891 · Cited by 372 · see citing works

Na+ -dependent transport in the intestine and other animal tissues.

Rk, C. (1966) · PubMed · Cited by 362 · see citing works

Cys‐scanning mutagenesis: a novel approach to structure—function relationships in polytopic membrane proteins

Frillingos, S., Sahin‐Tóth, M., Wu, J., & Kaback, H. R. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.13.1281 · Cited by 360 · see citing works

SUT2, a Putative Sucrose Sensor in Sieve Elements

Barker, L., Kühn, C., Weise, A., Schulz, A., Gebhardt, C., Hirner, B., Hellmann, H. A., Schulze, W. X., Ward, J. M., & Frommer, W. B. (2000) · The Plant Cell · doi:10.1105/tpc.12.7.1153 · Cited by 357 · see citing works

LESSONS FROM LACTOSE PERMEASE

Guan, L., & Kaback, H. R. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.102005 · Cited by 356 · see citing works

GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor

Takanaga, H., Chaudhuri, B., & Frommer, W. B. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.11.015 · Cited by 333 · see citing works

Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.

Holman, G. D., Kozka, I. J., CLARK, A. E., Flower, C. J., Saltis, J., Habberfield, A. D., Simpson, I. A., & Cushman, S. W. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44734-x · Cited by 329 · see citing works

AtKUP1: An Arabidopsis Gene Encoding High-Affinity Potassium Transport Activity

Kim, E. J., Kwak, J. M., Uozumi, N., & Schroeder, J. I. (1998) · The Plant Cell · doi:10.1105/tpc.10.1.51 · Cited by 327 · see citing works

Overexpression of the Vacuolar Sugar Carrier AtSWEET16 Modifies Germination, Growth, and Stress Tolerance in Arabidopsis

Klemens, P. A. W., Patzke, K., Deitmer, J. W., Spinner, L., Hir, R. L., Bellini, C., Bedu, M., Chardon, G., Krapp, A., & Neuhaus, H. E. (2013) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.224972 · Cited by 325 · see citing works

THE FATE OF SUGAR IN THE ANIMAL BODY

Cori, C. F. (1925) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84780-9 · Cited by 321 · see citing works

Purification and reconstitution of functional lactose carrier from Escherichia coli.

Newman, M. J., Foster, D. L., Wilson, T. H., & Kaback, H. R. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68477-2 · Cited by 311 · see citing works

A glucose sensor hiding in a family of transporters

Dı́ez-Sampedro, A., Hirayama, B. A., Osswald, C., Gorboulev, V., Baumgarten, K., Volk, C., Wright, E. M., & Koepsell, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733027100 · Cited by 308 · see citing works

Encyclopedia of Biophysics

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Comparative Genomic Analyses of the Bacterial Phosphotransferase System

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Imaging of the Dynamics of Glucose Uptake in the Cytosol of COS-7 Cells by Fluorescent Nanosensors

Fehr, M., Lalonde, S., Lager, I., Wolff, M. W., & Frommer, W. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301333200 · Cited by 295 · see citing works

Functional role of oligomerization for bacterial and plant SWEET sugar transporter family

Xuan, Y., Hu, Y., Chen, L., Sosso, D., Ducat, D. C., Hou, B., & Frommer, W. B. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311244110 · Cited by 289 · see citing works

Leaf Fructose Content Is Controlled by the Vacuolar Transporter SWEET17 in Arabidopsis

Chardon, G., Bedu, M., Calenge, F., Klemens, P. A. W., Spinner, L., Clément, G., Chietera, G., Léran, S., Ferrand, M., Lacombe, B., et al. (2013) · Current Biology · doi:10.1016/j.cub.2013.03.021 · Cited by 284 · see citing works

SWEET17, a Facilitative Transporter, Mediates Fructose Transport across the Tonoplast of Arabidopsis Roots and Leaves

Guo, W., Nagy, R., Chen, H., Pfrunder, S., Yu, Y.-C., Santelia, D., Frommer, W. B., & Martinoia, E. (2013) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.232751 · Cited by 282 · see citing works

Temporal Analysis of Sucrose-induced Phosphorylation Changes in Plasma Membrane Proteins of Arabidopsis

Niittylä, T., Fuglsang, A. T., Palmgren, M. B., Frommer, W. B., & Schulze, W. X. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700164-mcp200 · Cited by 275 · see citing works

Structure of a fucose transporter in an outward-open conformation

Dang, S., Sun, L., Huang, Y., Lu, F., Liu, Y., Gong, H., Wang, J., & Yan, N. (2010) · Nature · doi:10.1038/nature09406 · Cited by 273 · see citing works

New Observations on the Ultrastructure of the Membranes of Frog Peripheral Nerve Fibers

Robertson, J. D. (1957) · The Journal of Cell Biology · doi:10.1083/jcb.3.6.1043 · Cited by 259 · see citing works

Potato sucrose transporter expression in minor veins indicates a role in phloem loading.

Riesmeier, J. W., Hirner, B., & Frommer, W. B. (1993) · The Plant Cell · doi:10.1105/tpc.5.11.1591 · Cited by 255 · see citing works

Membrane Transport of Sugars and Amino Acids

Reinhold, L., & Kaplan, A. (1984) · Annual Review of Plant Physiology · doi:10.1146/annurev.pp.35.060184.000401 · Cited by 254 · see citing works

Xanthomonas axonopodis Virulence Is Promoted by a Transcription Activator-Like Effector–Mediated Induction of a SWEET Sugar Transporter in Cassava

Cohn, M. M., Bart, R. S., Shybut, M., Dahlbeck, D., Gómez, M. A. A., Morbitzer, R., Hou, B., Frommer, W. B., Lahaye, T., & Staskawicz, B. J. (2014) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-06-14-0161-r · Cited by 251 · see citing works

Lactose transport coupled to proton movements in escherichia coli

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Proton‐driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2

Schulz, A., Beyhl, D., Marten, I., Wormit, A., Neuhaus, H. E., Poschet, G., Büttner, M., Schneider, S., Sauer, N., & Hedrich, R. (2011) · The Plant Journal · doi:10.1111/j.1365-313x.2011.04672.x · Cited by 249 · see citing works

Alternating Access in Maltose Transporter Mediated by Rigid-Body Rotations

Khare, D., Oldham, M. L., Orelle, C., Davidson, A. L., & Chen, J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.035 · Cited by 242 · see citing works

Primary structure, genomic organization and heterologous expression of a glucose transporter from Arabidopsis thaliana.

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Phloem-localized, Proton-coupled Sucrose Carrier ZmSUT1 Mediates Sucrose Efflux under the Control of the Sucrose Gradient and the Proton Motive Force

Carpaneto, A., Geiger, D., Bamberg, E., Sauer, N., Fromm, J. H., & Hedrich, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501785200 · Cited by 235 · see citing works

Structural determination of wild-type lactose permease

Guan, L., Mirza, O., Verner, G., Iwata, S., & Kaback, H. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707688104 · Cited by 229 · see citing works

Quantitative Imaging with Fluorescent Biosensors

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Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs

Ghosh, S., Watanabe, R. M., Hauser, E. R., Valle, T. T., Magnuson, V. L., Erdos, M. R., Langefeld, C. D., Balow, J. E., Ally, D. S., Kohtamäki, K., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2198 · Cited by 224 · see citing works

Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)

van den Heuvel, L. P., Assink, K., Willemsen, M. A. A. P., & Monnens, L. A. H. (2002) · Human Genetics · doi:10.1007/s00439-002-0820-5 · Cited by 220 · see citing works

An Arabidopsis senescence-associated protein SAG29 regulates cell viability under high salinity

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Functional Analysis of an Arabidopsis thaliana Abiotic Stress-inducible Facilitated Diffusion Transporter for Monosaccharides

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Crystal Structure of the Maltose Transporter in a Pretranslocation Intermediate State

Oldham, M. L., & Chen, J. (2011) · Science · doi:10.1126/science.1200767 · Cited by 209 · see citing works

Will the original glucose transporter isoform please stand up!

Carruthers, A., Zutter, J. K. D., Ganguly, A., & Devaskar, S. U. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00496.2009 · Cited by 202 · see citing works

The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein.

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EVIDENCE OF ACTIVE TRANSFER OF CERTAIN NON-ELECTROLYTES ACROSS THE HUMAN RED CELL MEMBRANE

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SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose

Tazawa, S., Yamato, T., Fujikura, H., Hiratochi, M., Itoh, F., Tomae, M., Takemura, Y., Maruyama, H., Sugiyama, T., Wakamatsu, A., et al. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.10.016 · Cited by 200 · see citing works

Studies on the mechanism of intestinal absorption of sugars V. The influence of several cations and anions on the active transport of sugars, in vitro, by various preparations of hamster small intestine

BIHLER, I., & Crane, R. K. (1962) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(62)90699-6 · Cited by 197 · see citing works

The mechanism of sodium and substrate release from the binding pocket of vSGLT

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The Solute Carrier Families Have a Remarkably Long Evolutionary History with the Majority of the Human Families Present before Divergence of Bilaterian Species

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Snapshots of the maltose transporter during ATP hydrolysis

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Sugar, Amino Acid, and NA+ Cotransport in the Proximal Tubule

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Membrane Microdomains, Rafts, and Detergent-Resistant Membranes in Plants and Fungi

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[Galactoside-permease of Escherichia coli].

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Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY

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