Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, Matthew G., Cantley, Lewis C., Thompson, Craig B.·2009·Science

DOI 10.1126/science.1160809

Cited by (1,190)

Items 701–800 of 1,190

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Shlomi, Tomer, Benyamini, Tomer, Gottlieb, Eyal, Sharan, Roded, Ruppin, Eytan · 2011 · PLoS Computational Biology
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Angelika Bröer, Farid Rahimi, Stefan Bröer · 2016 · Journal of Biological Chemistry
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Weijie Guo, Zhaoping Qiu, Zhichao Wang, Qifeng Wang, Ning Tan, Taoyang Chen, Zhiao Chen, Shenglin Huang, Jianren Gu, Jinjun Li et al. · 2015 · Hepatology
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Eran Mick, Denis V. Titov, Owen S. Skinner, Rohit Sharma, Alexis A. Jourdain, Vamsi K. Mootha · 2020 · eLife
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P. Poornima, J. Dinesh Kumar, Qiaoli Zhao, Martina Blunder, Thomas Efferth · 2016 · Pharmacological Research
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