The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer
Open accessAbstract
Human colorectal cancers (CRCs) display a large number of genetic and epigenetic alterations, some of which are causally involved in tumorigenesis (drivers) and others that have little functional impact (passengers). To help distinguish between these two classes of alterations, we used a transposon-based genetic screen in mice to identify candidate genes for CRC. Mice harboring mutagenic Sleeping Beauty (SB) transposons were crossed with mice expressing SB transposase in gastrointestinal tract epithelium. Most of the offspring developed intestinal lesions, including intraepithelial neoplasia, adenomas, and adenocarcinomas. Analysis of over 16,000 transposon insertions identified 77 candidate CRC genes, 60 of which are mutated and/or dysregulated in human CRC and thus are most likely to drive tumorigenesis. These genes include APC, PTEN , and SMAD4 . The screen also identified 17 candidate genes that had not previously been implicated in CRC, including POLI, PTPRK , and RSPO2 .
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A census of human cancer genes
Futreal, P. A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., Rahman, N., & Stratton, M. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1299 · Cited by 3,184
Colorectal cancer and genetic alterations in the Wnt pathway
Segditsas, S., & Tomlinson, I. (2006) · Oncogene · doi:10.1038/sj.onc.1210059 · Cited by 591
Wang, Y., Woodgate, R., McManus, T. P., Mead, S., McCormick, J. J., & Maher, V. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3073 · Cited by 120
Cited by
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
Varela, I., Tarpey, P., Raine, K., Huang, D., Ong, C. K., Stephens, P., Davies, H., Jones, D., Lin, M.-L., Teague, J., et al. (2011) · Nature · doi:10.1038/nature09639 · Cited by 1,123
Self-citationRecurrent R-spondin fusions in colon cancer
Seshagiri, S., Stawiski, E. W., Durinck, S., Modrusan, Z., Storm, E. E., Conboy, C. B., Chaudhuri, S., Guan, Y., Janakiraman, V., Jaiswal, B. S., et al. (2012) · Nature · doi:10.1038/nature11282 · Cited by 960
Self-citationA hyperactive piggyBac transposase for mammalian applications
Yusa, K., Zhou, L., Li, M. A., Bradley, A., & Craig, N. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008322108 · Cited by 770
Secreted and transmembrane wnt inhibitors and activators
Cruciat, C.-M., & Niehrs, C. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015081 · Cited by 646
Transposon-mediated genome manipulation in vertebrates
Ivics, Z., Li, M. A., Mátés, L., Boeke, J. D., Nagy, A., Bradley, A., & Izsvák, Z. (2009) · Nature Methods · doi:10.1038/nmeth.1332 · Cited by 297
Metadata
- Authors
- Starr, T. K., Allaei, R., Silverstein, K. A. T., Staggs, R. A., Sarver, A. L., Bergemann, T. L., Gupta, M., O'Sullivan, M. G., Matise, I., Dupuy, A. J., Collier, L. S., Powers, S., Oberg, A. L., Asmann, Y. W., Thibodeau, S. N., Tessarollo, L., Copeland, N. G., Jenkins, N. A., Cormier, R. T., & Largaespada, D. A.
- Venue
- Science
- Published
- 2009-03-27
- Volume
- 323
- Issue
- 5922
- Pages
- 1747-1750
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065833903
- Cited by
- 346
- References
- 3
- FWCI
- 24.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Starr, T. K., Allaei, R., Silverstein, K. A. T., Staggs, R. A., Sarver, A. L., Bergemann, T. L., Gupta, M., O'Sullivan, M. G., Matise, I., Dupuy, A. J., Collier, L. S., Powers, S., Oberg, A. L., Asmann, Y. W., Thibodeau, S. N., Tessarollo, L., Copeland, N. G., Jenkins, N. A., Cormier, R. T., & Largaespada, D. A. (2009). A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer. Science. https://doi.org/10.1126/science.1163040
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
