The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg 2+ Homeostasis
Open accessAbstract
The gene transient receptor potential-melastatin-like 7 ( Trpm7 ) encodes a protein that functions as an ion channel and a kinase. TRPM7 has been proposed to be required for cellular Mg 2+ homeostasis in vertebrates. Deletion of mouse Trpm7 revealed that it is essential for embryonic development. Tissue-specific deletion of Trpm7 in the T cell lineage disrupted thymopoiesis, which led to a developmental block of thymocytes at the double-negative stage and a progressive depletion of thymic medullary cells. However, deletion of Trpm7 in T cells did not affect acute uptake of Mg 2+ or the maintenance of total cellular Mg 2+ . Trpm7 -deficient thymocytes exhibited dysregulated synthesis of many growth factors that are necessary for the differentiation and maintenance of thymic epithelial cells. The thymic medullary cells lost signal transducer and activator of transcription 3 activity, which accounts for their depletion when Trpm7 is disrupted in thymocytes.
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Cites
AN INTRODUCTION TO TRP CHANNELS
Ramsey, I. S., Delling, M., & Clapham, D. E. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.100431 · Cited by 1,551
Self-citationThe iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
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Self-citationLTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability
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Self-citationRegulation of Vertebrate Cellular Mg2+ Homeostasis by TRPM7
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Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia
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Cited by
Magnesium in man: implications for health and disease
de Baaij, J. H. F., Hoenderop, J. G. J., & Bindels, R. J. M. (2015) · Physiological Reviews · doi:10.1152/physrev.00012.2014 · Cited by 1,726
Ion Channels in Innate and Adaptive Immunity
Feske, S., Wulff, H., & Skolnik, E. Y. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112212 · Cited by 768
The functional network of ion channels in T lymphocytes
Cahalan, M. D., & Chandy, K. G. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00816.x · Cited by 599
Second messenger role for Mg2+ revealed by human T-cell immunodeficiency
Li, F.-Y., Chaigne-Delalande, B., Kanellopoulou, C., Davis, J. C., Matthews, H. F., Douek, D. C., Cohen, J. I., Uzel, G., Su, H. C., & Lenardo, M. J. (2011) · Nature · doi:10.1038/nature10246 · Cited by 560
Cellular magnesium homeostasis
Romani, A. M. P. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.05.010 · Cited by 531
Metadata
- Authors
- Jin, J., Desai, B. N., Navarro, B., Donovan, A., Andrews, N. C., & Clapham, D. E.
- Venue
- Science
- Published
- 2008-10-31
- Volume
- 322
- Issue
- 5902
- Pages
- 756-760
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022645001
- Cited by
- 416
- References
- 25
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Jin, J., Desai, B. N., Navarro, B., Donovan, A., Andrews, N. C., & Clapham, D. E. (2008). Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg 2+ Homeostasis. Science. https://doi.org/10.1126/science.1163493
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