The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Open accessAbstract
Telomerase is a ribonucleoprotein (RNP) complex that synthesizes telomere repeats in tissue progenitor cells and cancer cells. Active human telomerase consists of at least three principal subunits, including the telomerase reverse transcriptase, the telomerase RNA (TERC), and dyskerin. Here, we identify a holoenzyme subunit, TCAB1 (telomerase Cajal body protein 1), that is notably enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. TCAB1 associates with active telomerase enzyme, established telomerase components, and small Cajal body RNAs that are involved in modifying splicing RNAs. Depletion of TCAB1 by using RNA interference prevents TERC from associating with Cajal bodies, disrupts telomerase-telomere association, and abrogates telomere synthesis by telomerase. Thus, TCAB1 controls telomerase trafficking and is required for telomere synthesis in human cancer cells.
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“TCAB1 (also known as WDR79) is a WD40-repeat containing protein that associates with dyskerin and binds the CAB box in scaRNAs (46,47).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [46]
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Citations
Cites
A telomerase component is defective in the human disease dyskeratosis congenita
Mitchell, J. R., Wood, E., & Collins, K. (1999) · Nature · doi:10.1038/990141 · Cited by 1,168
Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs
Matera, A. G., Terns, R. M., & Terns, M. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2124 · Cited by 877
Self-citationThe POT1-TPP1 telomere complex is a telomerase processivity factor.
Wang, F., Podell, E. R., Zaug, A. J., Yang, Y., Baciu, P., Cech, T. R., & Lei, M. (2007) · Nature · doi:10.1038/nature05454 · Cited by 704
Protein Composition of Catalytically Active Human Telomerase from Immortal Cells
Cohen, S. B., Graham, M. E., Lovrecz, G. O., Bache, N., Robinson, P. J., & Reddel, R. R. (2007) · Science · doi:10.1126/science.1138596 · Cited by 669
TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase
Xin, H., Liu, D., Wan, M., Safari, A., Kim, H., Sun, W., O’Connor, M. S., & Songyang, Z. (2007) · Nature · doi:10.1038/nature05469 · Cited by 518
Cell Cycle-regulated Trafficking of Human Telomerase to Telomeres
Tomlinson, R. L., Ziegler, T. D., Supakorndej, T., Terns, R. M., & Terns, M. P. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-09-0903 · Cited by 339
Self-citationVenteicher, A. S., Meng, Z., Mason, P. J., Veenstra, T. D., & Artandi, S. E. (2008) · Cell · doi:10.1016/j.cell.2008.01.019 · Cited by 329
Self-citationHuman telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal
Jády, B. E., Bertrand, É., & Kiss, T. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310138 · Cited by 287
The biogenesis and regulation of telomerase holoenzymes
Collins, K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1961 · Cited by 287
The many facets of H/ACA ribonucleoproteins
Meier, U. T. (2005) · Chromosoma · doi:10.1007/s00412-005-0333-9 · Cited by 281
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Qiu, J., Xia, Y., Bao, Y., Cheng, J., Liu, L., & Qian, D. (2024) · Figshare · doi:10.6084/m9.figshare.26687900
Qiu, J., Xia, Y., Bao, Y., Cheng, J., Liu, L., & Qian, D. (2024) · Figshare · doi:10.6084/m9.figshare.26687915
Qiu, J., Xia, Y., Bao, Y., Cheng, J., Liu, L., & Qian, D. (2024) · Figshare · doi:10.6084/m9.figshare.26687906
Keegan, J., Sorbello, S., Mori, J., Muratani, S., Leshchiner, I., Heaphy, C. M., & Flynn, R. L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.02.691864
Balgote, P. J., Nowshad, F., Patnaik, A. R., & Sivaraman, J. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-01972-8
Relations between aortic valve calcification and telomere lenght dynamics
Saraieva, I. (2020) · theses.fr (ABES) · doi:10.70675/c98af202z0365z444bz8ee1z337555d97246
Daskalova, E., Lee, J. S., Zahmanova, G., & Minkov, I. N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083478
Complex structural variations functionally inactivate the telomerase chaperone TCAB1 in osteosarcoma
Keegan, J., Sorbello, S., Mori, J., Muratani, S., Leshchiner, I., Heaphy, C. M., & Flynn, R. L. (2026) · BMC Cancer · doi:10.1186/s12885-026-16250-5
Zhan, H., Zheng, R., Li, Y., Liu, X. W., Shi, Y., Chen, R., Hou, Q., Huang, H. F., & Lin, M. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.06.034
Zuo, H., Gao, X., Wang, Y., Yan, Y., Ru, Y., Zhao, J., Chen, X., Zhang, Y., Ma, X., Liu, X., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00753
La1: an evolutionarily conserved player in the Arabidopsis telomerase complex
Phadke, C. R., Mishra, S., Song, J., Holtsclaw, R. E., Castillo-González, C., Kundel, I., Marcotte, E. M., Papoulas, O., & Shippen, D. E. (2026) · Plant Cell Reports · doi:10.1007/s00299-026-03923-5
Thiomorpholino antisense oligonucleotides inhibit telomerase and limit cancer cell proliferationPreprint
Rivosecchi, J., Zaug, A. J., Lášek, T., Schäfer, B., Caruthers, M. H., & Cech, T. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.28.754723
BIOGENESIS OF TELOMERASE RNA IN FISSION YEAST
Tang, W. (2012)
Frohnert, C. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4344
Functional Analysis of ACD Mutations in Dyskeratosis Congenita.
Koçak, H. (2014) · Deep Blue (University of Michigan)
Metadata
- Authors
- Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E.
- Affiliations
- Leidos (United States) (US)
- Corresponding author
- Abreu, Eladio B.
- Meng, Zhaojing
- Artandi, Steven E.
- ORCID
- Venue
- Science
- Published
- 2009-01-30
- Volume
- 323
- Issue
- 5914
- Pages
- 644-648
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2728071
- OpenAlex
- W2014414194
- Cited by
- 522
- References
- 23
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 20 · 2023: 18 · 2022: 22 · 2021: 30 · 2020: 29 · 2019: 27 · 2018: 28 · 2017: 29 · 2016: 43 · 2015: 39 · 2014: 40 · 2013: 37 · 2012: 35
- FWCI
- 29.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DigitalCommons-Cedarville (Cedarville University) (submittedVersion)
- Funders
- National Institutes of Health (n01co12400-79-0-22)
- National Cancer Institute (N01CO12400, CA111691, N01-CO-012400, R01CA125453, CA125453, R01CA111691, CA104676, R01CA104676)
- National Institute of General Medical Sciences (T32GM007365, GM 07365)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- telomerase, telomerase holoenzyme, Cajal bodies, telomere synthesis, dyskerin, ribonucleoprotein complexes, cancer cells
- MeSH terms
- Amino Acid Sequence, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, RNA, Telomere, Cell Cycle Proteins, Molecular Chaperones, Telomerase, Coiled Bodies, RNA Interference, Cell Line, Tumor, Immunoprecipitation
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