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A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
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Telomerase is a ribonucleoprotein (RNP) complex that synthesizes telomere repeats in tissue progenitor cells and cancer cells. Active human telomerase consists of at least three principal subunits, including the telomerase reverse transcriptase, the telomerase RNA (TERC), and dyskerin. Here, we identify a holoenzyme subunit, TCAB1 (telomerase Cajal body protein 1), that is notably enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. TCAB1 associates with active telomerase enzyme, established telomerase components, and small Cajal body RNAs that are involved in modifying splicing RNAs. Depletion of TCAB1 by using RNA interference prevents TERC from associating with Cajal bodies, disrupts telomerase-telomere association, and abrogates telomere synthesis by telomerase. Thus, TCAB1 controls telomerase trafficking and is required for telomere synthesis in human cancer cells.
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“TCAB1 (also known as WDR79) is a WD40-repeat containing protein that associates with dyskerin and binds the CAB box in scaRNAs (46,47).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [46]
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Metadata
- Authors
- Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E.
- Affiliations
- Leidos (United States) (US)
- Corresponding author
- Abreu, Eladio B.
- Meng, Zhaojing
- Artandi, Steven E.
- ORCID
- Venue
- Science
- Published
- 2009-01-30
- Volume
- 323
- Issue
- 5914
- Pages
- 644-648
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2728071
- OpenAlex
- W2014414194
- Cited by
- 522
- References
- 23
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 20 · 2023: 18 · 2022: 22 · 2021: 30 · 2020: 29 · 2019: 27 · 2018: 28 · 2017: 29 · 2016: 43 · 2015: 39 · 2014: 40 · 2013: 37 · 2012: 35
- FWCI
- 29.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DigitalCommons-Cedarville (Cedarville University) (submittedVersion)
- Funders
- National Institutes of Health (n01co12400-79-0-22)
- National Cancer Institute (N01CO12400, CA111691, N01-CO-012400, R01CA125453, CA125453, R01CA111691, CA104676, R01CA104676)
- National Institute of General Medical Sciences (T32GM007365, GM 07365)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- telomerase, telomerase holoenzyme, Cajal bodies, telomere synthesis, dyskerin, ribonucleoprotein complexes, cancer cells
- MeSH terms
- Amino Acid Sequence, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, RNA, Telomere, Cell Cycle Proteins, Molecular Chaperones, Telomerase, Coiled Bodies, RNA Interference, Cell Line, Tumor, Immunoprecipitation
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