The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Axon Regeneration Requires a Conserved MAP Kinase Pathway
Open accessAbstract
Regeneration of injured neurons can restore function, but most neurons regenerate poorly or not at all. The failure to regenerate in some cases is due to a lack of activation of cell-intrinsic regeneration pathways. These pathways might be targeted for the development of therapies that can restore neuron function after injury or disease. Here, we show that the DLK-1 mitogen-activated protein (MAP) kinase pathway is essential for regeneration in Caenorhabditis elegans motor neurons. Loss of this pathway eliminates regeneration, whereas activating it improves regeneration. Further, these proteins also regulate the later step of growth cone migration. We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
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Functional regeneration after laser axotomy
Yanik, M. F., Cinar, H., Cinar, H. N., Chisholm, A. D., Jin, Y., & Ben-Yakar, A. (2004) · Nature · doi:10.1038/432822a · Cited by 598
Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones
Campbell, D. S., & Holt, C. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00158-2 · Cited by 303
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Huang, Y.-W. A., Zhou, B., Wernig, M., & Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2016.12.044 · Cited by 528
Wallerian Degeneration, WldS, and Nmnat
Coleman, M. P., & Freeman, M. R. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153248 · Cited by 473
Neuronal Intrinsic Mechanisms of Axon Regeneration
Liu, K., Tedeschi, A., Park, K. K., & He, Z. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113723 · Cited by 458
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Sengupta Ghosh, A., Wang, B., Pozniak, C. D., Chen, M., Watts, R. J., & Lewcock, J. W. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201103153 · Cited by 220
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
Huntwork-Rodriguez, S., Wang, B., Watkins, T., Ghosh, A. S., Pozniak, C. D., Bustos, D., Newton, K., Kirkpatrick, D. S., & Lewcock, J. W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201303066 · Cited by 154
A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans
Wang, S., Tang, N. H., Lara-Gonzalez, P., Zhao, Z., Cheerambathur, D. K., Prevo, B., Chisholm, A. D., Desai, A., & Oegema, K. (2017) · Development · doi:10.1242/dev.150094 · Cited by 119
Dock GEFs and their therapeutic potential: Neuroprotection and axon regeneration
Namekata, K., Kimura, A., Kawamura, K., Harada, C., & Harada, T. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.06.005 · Cited by 57
Sekine, Y., Lin-Moore, A., Chenette, D. M., Wang, X., Jiang, Z., Cafferty, W. B., Hammarlund, M., & Strittmatter, S. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.058 · Cited by 52
Self-citationLazaro-Pena, M. I., Cornwell, A. B., Diaz-Balzac, C. A., Das, R., Ward, Z. C., Macoretta, N., Thakar, J., & Samuelson, A. V. (2023) · eLife · doi:10.7554/elife.85792 · Cited by 11
Metadata
- Authors
- Hammarlund, M., Nix, P., Hauth, L., Jorgensen, E. M., & Bastiani, M.
- Venue
- Science
- Published
- 2009-02-06
- Volume
- 323
- Issue
- 5915
- Pages
- 802-806
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013500926
- Cited by
- 451
- References
- 3
- FWCI
- 13.55
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
