Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 462

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

A Functional Genomics Approach Reveals CHE as a Component of the Arabidopsis Circadian Clock

Open access
Pruneda-Paz, Jose L., Breton, Ghislain, Para, Alessia, Kay, Steve A.·2009·Science

Abstract

Transcriptional feedback loops constitute the molecular circuitry of the plant circadian clock. In Arabidopsis , a core loop is established between CCA1 and TOC1. Although CCA1 directly represses TOC1 , the TOC1 protein has no DNA binding domains, which suggests that it cannot directly regulate CCA1 . We established a functional genomic strategy that led to the identification of CHE, a TCP transcription factor that binds specifically to the CCA1 promoter. CHE is a clock component partially redundant with LHY in the repression of CCA1 . The expression of CHE is regulated by CCA1, thus adding a CCA1/CHE feedback loop to the Arabidopsis circadian network. Because CHE and TOC1 interact, and CHE binds to the CCA1 promoter, a molecular linkage between TOC1 and CCA1 gene regulation is established.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.1167206

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 19 references

Cited by

See all 462

Metadata

Authors
Pruneda-Paz, J. L., Breton, G., Para, A., & Kay, S. A.
Venue
Science
Published
2009-03-13
Volume
323
Issue
5920
Pages
1481-1485
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2024952216
Cited by
462
References
19
FWCI
52.90
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: A Functional Genomics Approach Reveals CHE as a Component of the Arabidopsis Circadian Clock. https://app.cochat.ai/papers/10.1126/science.1167206
The paper
Pruneda-Paz, J. L., Breton, G., Para, A., & Kay, S. A. (2009). A Functional Genomics Approach Reveals CHE as a Component of the Arabidopsis Circadian Clock. Science. https://doi.org/10.1126/science.1167206

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.