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Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer
Open accessAbstract
The sensitivity of both nuclear magnetic resonance spectroscopy and magnetic resonance imaging is very low because the detected signal strength depends on the small population difference between spin states even in high magnetic fields. Hyperpolarization methods can be used to increase this difference and thereby enhance signal strength. This has been achieved previously by incorporating the molecular spin singlet para-hydrogen into hydrogenation reaction products. We show here that a metal complex can facilitate the reversible interaction of para-hydrogen with a suitable organic substrate such that up to an 800-fold increase in proton, carbon, and nitrogen signal strengths are seen for the substrate without its hydrogenation. These polarized signals can be selectively detected when combined with methods that suppress background signals.
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Cited by
Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681
Self-citationModalities, Modes, and Models in Functional Neuroimaging
Friston, K. J. (2009) · Science · doi:10.1126/science.1174521 · Cited by 489
The theory and practice of hyperpolarization in magnetic resonance using parahydrogen
Green, R. A., Adams, R. W., Duckett, S. B., Mewis, R. E., Williamson, D. C., & Green, G. G. R. (2012) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2012.03.001 · Cited by 381
Self-citationParahydrogen‐Based Hyperpolarization for Biomedicine
Hövener, J., Pravdivtsev, A. N., Kidd, B., Bowers, C. R., Glöggler, S., Kovtunov, K. V., Plaumann, M., Katz‐Brull, R., Buckenmaier, K., Jerschow, A., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201711842 · Cited by 346
ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate
Reineri, F., Boi, T., & Aime, S. (2015) · Nature Communications · doi:10.1038/ncomms6858 · Cited by 296
Metadata
- Authors
- Adams, R. W., Aguilar, J. A., Atkinson, K. D., Cowley, M. J., Elliott, P. I. P., Duckett, S. B., Green, G. G. R., Khazal, I. G., López-Serrano, J., & Williamson, D. C.
- Venue
- Science
- Published
- 2009-03-27
- Volume
- 323
- Issue
- 5922
- Pages
- 1708-1711
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2110111386
- Cited by
- 1,031
- References
- 0
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Adams, R. W., Aguilar, J. A., Atkinson, K. D., Cowley, M. J., Elliott, P. I. P., Duckett, S. B., Green, G. G. R., Khazal, I. G., López-Serrano, J., & Williamson, D. C. (2009). Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer. Science. https://doi.org/10.1126/science.1168877
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