The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
High-Throughput Sequencing of the Zebrafish Antibody Repertoire
Open accessAbstract
Antibody Repertoire Revealed: Antibodies produced by B cells protect us against infection by a wide array of pathogens. Such wide-ranging responses are possible because the specific domain of the antibody that binds to the invader is highly variable owing to the somatic recombination of an inherited set of gene segments that encode the antibody molecule. Although antibody diversity within an individual organism is well-established, the specific antibody repertoire of an individual organism has not been characterized. Using high-throughput sequencing technology, Weinstein et al. (p. 807 ) characterized the diversity of the antigen-binding domain of the antibody heavy chain in zebrafish. The antibody repertoire of individual fish covered at least 50% of the possible gene combinations. Although the specific gene combinations differed between fish, a similar frequency distribution of the repertoire was observed. Unexpected examples of evolutionary conversion were also seen, with the same antibody observed in different animals.
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Cites
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Cited by
Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications
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Are Biological Systems Poised at Criticality?
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The promise and challenge of high-throughput sequencing of the antibody repertoire
Georgiou, G., Ippolito, G. C., Beausang, J., Busse, C. E., Wardemann, H., & Quake, S. R. (2014) · Nature Biotechnology · doi:10.1038/nbt.2782 · Cited by 652
New concepts in the generation and functions of IgA
Pabst, O. (2012) · Nature reviews. Immunology · doi:10.1038/nri3322 · Cited by 656
Glanville, J., Zhai, W., Berka, J., Telman, D., Huerta, G., Mehta, G. R., Ni, I., Mei, L., Sundar, P. D., Day, G. M. R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909775106 · Cited by 440
Metadata
- Authors
- Weinstein, J. A., Jiang, N., White, R. A., Fisher, D. S., & Quake, S. R.
- Venue
- Science
- Published
- 2009-05-08
- Volume
- 324
- Issue
- 5928
- Pages
- 807-810
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022824615
- Cited by
- 431
- References
- 12
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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