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Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
Open accessAbstract
Heterozygous mutations in the gene encoding isocitrate dehydrogenase-1 ( IDH1 ) occur in certain human brain tumors, but their mechanistic role in tumor development is unknown. We have shown that tumor-derived IDH1 mutations impair the enzyme's affinity for its substrate and dominantly inhibit wild-type IDH1 activity through the formation of catalytically inactive heterodimers. Forced expression of mutant IDH1 in cultured cells reduces formation of the enzyme product, α-ketoglutarate (α-KG), and increases the levels of hypoxia-inducible factor subunit HIF-1α, a transcription factor that facilitates tumor growth when oxygen is low and whose stability is regulated by α-KG. The rise in HIF-1α levels was reversible by an α-KG derivative. HIF-1α levels were higher in human gliomas harboring an IDH1 mutation than in tumors without a mutation. Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.
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“HIF is stabilized in IDH-associated gliomas; this has been proposed to be a consequence of intracellular depletion of 2OG following IDH loss of function (Zhao et al, 2009).”
From The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases (2011) · cites this paper as Zhao et al, 2009
In the citing paper
“The IDH mutations occur at substrate-binding arginine residues (Arg 132 in IDH1; Arg 140 and Arg 172 in IDH2) and inactivate IDH for conversion of isocitrate to 2-oxoglutarate (2OG; Zhao et al, 2009).”
From The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases (2011) · cites this paper as Zhao et al, 2009
In the citing paper
“Overexpression of IDH1 Arg 132 mutants results in elevated HIFa levels (Zhao et al, 2009).”
From The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases (2011) · cites this paper as Zhao et al, 2009
In the citing paper
“The stability of HIF‐1α is regulated by α‐KG, and increasing α‐KG reduces the expression of HIF‐1α.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [168]
In the citing paper
“Inhibiting the mitochondrial enzyme SDH during ischaemia by preloading tissues with the SDH inhibitor DMM prevented succinate accumulation during ischaemia and protected against tissue damage upon reperfusion150.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [150]
In the citing paper
“succinate accumulated during ischaemia and is then oxidised upon reperfusion to drive the mitochondrial superoxide formation that contributes to ischaemia-reperfusion (IR) injury150,151.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [150]
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An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
IDH1 and IDH2 Mutations in Gliomas
Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847
Malignant astrocytic glioma: genetics, biology, and paths to treatment
Furnari, F. B., Fenton, T., Bachoo, R. M., Mukasa, A., Stommel, J. M., Stegh, A., Hahn, W. C., Ligon, K. L., Louis, D. N., Brennan, C., et al. (2007) · Genes & Development · doi:10.1101/gad.1596707 · Cited by 2,316
Analysis of the IDH1 codon 132 mutation in brain tumors
Balss, J., Meyer, J., Mueller, W., Korshunov, A., Hartmann, C., & von Deimling, A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0455-2 · Cited by 1,036
Xu, X., Zhao, J., Xu, Z., Peng, B., Huang, Q., Arnold, E., & Ding, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404298200 · Cited by 407
Self-citationBleeker, F. E., Lamba, S., Leenstra, S., Troost, D., Hulsebos, T. J. M., Vandertop, W. P., Frattini, M., Molinari, F., Knowles, M. A., Cerrato, A., et al. (2009) · Human Mutation · doi:10.1002/humu.20937 · Cited by 365
Evaluation of HIF-1 inhibitors as anticancer agents
Semenza, G. L. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.08.006 · Cited by 363
MacKenzie, E. D., Selak, M. A., Tennant, D. A., Payne, L. J., Crosby, S., Frederiksen, C. M., Watson, D. G., & Gottlieb, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01927-06 · Cited by 359
Cellular concentrations of enzymes and their substrates
Albe, K. R., Butler, M. H., & Wright, B. E. (1990) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(05)80266-8 · Cited by 318
Multiple NADPH-producing pathways control glutathione (GSH) content in retina
Winkler, B. S., Desantis, N. M., & Solomon, F. (1986) · Experimental Eye Research · doi:10.1016/s0014-4835(86)80013-6 · Cited by 107
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Choate, K. A., Raack, E. J., Line, V. F., Jennings, M. J., Belton, R. J., Winn, R. J., & Mann, P. B. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291666 · Cited by 11
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Wang, J. Y., & Bettegowda, C. (2015) · Journal of Neuro-Oncology · doi:10.1007/s11060-015-1730-4 · Cited by 12
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Yao, Y. (2014) · Medical Science Monitor · doi:10.12659/msm.889891 · Cited by 11
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Richterová, R., Jurečeková, J., Evinová, A., Kolarovszki, B., Benčo, M., RIGGO, J. D., Šutovský, J., Mahmood, S., Račay, P., & Dobrota, D. (2014) · General Physiology and Biophysics · doi:10.4149/gpb_2014007 · Cited by 11
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Morris, J. H., Meng, E. C., & Ferrin, T. E. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r000007-mcp201 · Cited by 11
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Gan, L.-L., Chen, L., & Nan, F. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.75 · Cited by 11
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Snezhkina, A. V., Lukyanova, E., Zaretsky, A. R., Kalinin, D. V., Pokrovsky, A. V., Golovyuk, A. L., Krasnov, G. S., Fedorova, M., Pudova, E. A., Kharitonov, S., et al. (2019) · BMC Medical Genetics · doi:10.1186/s12881-019-0770-6 · Cited by 11
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Gregorio, E. D., Miolo, G., Saorin, A., Steffan, A., & Corona, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115574 · Cited by 11
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Cho, N. S., Hagiwara, A., Eldred, B. S. C., Raymond, C., Wang, C., Sanvito, F., Lai, A., Nghiemphu, P. L., Salamon, N., Steelman, L., et al. (2022) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdac124 · Cited by 11
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Horton, J. R., Gale, M., Yan, Q., & Cheng, X. (2017) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-59786-7_7 · Cited by 10
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Scott, J. G., Basanta, D., Chinnaiyan, P., Canoll, P., Swanson, K. R., & Anderson, A. R. A. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor083 · Cited by 9
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Park, G. H. J., Yang, S.-H., & Baek, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203379 · Cited by 9
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Wang, L., He, S., Xiong, Z., Lu, J., Lin, Y., Jin, H., & Yang, L. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112031 · Cited by 8
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Miskevich, D. A., Chaban, A., Dronina, M. A., Abramovich, I., Gottlieb, E., & Shams, I. (2021) · Metabolites · doi:10.3390/metabo11110734 · Cited by 6
Chen, T., Yao, C., Chen, Y., Yuan, C., Lin, C., Hsu, Y.-C., Chuang, P., Kao, C., Li, Y.-H., Hou, H., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02193-1 · Cited by 7
Zhang, Y., Lv, W., Li, Q., Wang, Q., Ru, Y., Xiong, X., Yan, F., Pan, T., Lin, W. J., & Li, X. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10418 · Cited by 6
Diagnostic and prognostic molecular markers in common adult gliomas
Rivera, A. L., & Pelloski, C. E. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.44 · Cited by 6
Alberti, G., D’Amico, G., Augello, M. A., Cappello, F., Szychlinska, M. A., Bavisotto, C. C., & Scalia, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010373 · Cited by 5
Iron promotes isocitrate dehydrogenase mutant glioma cell motility
Owusu, S. B., Russell, E., Ekanayake, A. B., Tivanski, A. V., & Petronek, M. S. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.032 · Cited by 5
Wu, S., Ding, L., Xu, H., Gao, J., Shao, Y., Zhang, S., & Wei, Z. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s251915 · Cited by 5
Qiu, J., Wu, K., Zhu, M., Chen, C. Y., Luo, Y., Liu, Y., & Wen, J. (2022) · European Journal of Radiology · doi:10.1016/j.ejrad.2022.110502 · Cited by 5
Liu, H., Li, W., An, Y., Wu, T., Jiang, G., Dong, Y., Chen, W., Wang, J., Wang, C., & Song, S. (2022) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320221139262 · Cited by 5
Qiu, J., Zhu, M., Chen, C., Luo, Y., & Wen, J. (2023) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2023.09.004 · Cited by 5
Funck‐Brentano, T., Cohen-Solal, M. E., Ducray, F., & Mandonnet, E. (2024) · Bone · doi:10.1016/j.bone.2024.117221 · Cited by 6
Mechanisms of Aggressiveness in Glioblastoma: Prognostic and Potential Therapeutic Insights
Celine, S., Lourenço, T., Xavier‐Magalhães, A., Pojo, M., & Bruno, M. (2013) · InTech eBooks · doi:10.5772/52361 · Cited by 5
Modeling dioxygenase enzyme kinetics in familial paraganglioma
Peters, J. P., Her, Y. F., & Maher, L. J. (2015) · Biology Open · doi:10.1242/bio.013623 · Cited by 4
Wick, W., & Weller, M. (2010) · Der Nervenarzt · doi:10.1007/s00115-010-2956-1 · Cited by 5
New views on the selection acting on genetic polymorphism in central metabolic genes
Eanes, W. F. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13285 · Cited by 7
Roles of long non-coding RNAs in the hallmarks of glioma
Xue, B., Xiang, W., Zhang, Q., Wang, Y.-H., Wang, H.-F., Yi, D., Xiong, N.-X., Jiang, X.-B., Zhao, H.-Y., & Fu, P. (2020) · Oncology Letters · doi:10.3892/ol.2020.11944 · Cited by 5
Wang, C., & Dong, H. (2021) · Acta Radiologica · doi:10.1177/02841851211011914 · Cited by 5
Adult High-Grade (Diffuse) Glioma
McNeill, K. A., Aldape, K., & Fine, H. A. (2014) · Molecular pathology library · doi:10.1007/978-1-4939-1830-0_6 · Cited by 5
Metadata
- Authors
- Zhao, S., Lin, Y., Xu, W., Jiang, W., Zha, Z., Wang, P., Yu, W., Li, Z., Gong, L., Peng, Y., Ding, J., Lei, Q., Guan, K.-L., & Xiong, Y.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Molecular and Cell Biology Laboratory, Institute of Biomedical Sciences, Fudan University, 130 Dong-An Road, Shanghai 200032, China.
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Lin, Yan
- Xu, Wei
- Jiang, Wenqing
- Guan, Kun-Liang
- Xiong, Yue
- ORCID
- Venue
- Science
- Published
- 2009-04-10
- Volume
- 324
- Issue
- 5924
- Pages
- 261-265
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3251015
- OpenAlex
- W1964150693
- Cited by
- 1,119
- References
- 12
- Citations by year
- 2026: 24 · 2025: 27 · 2024: 43 · 2023: 36 · 2022: 50 · 2021: 62 · 2020: 58 · 2019: 54 · 2018: 63 · 2017: 71 · 2016: 57 · 2015: 71 · 2014: 74 · 2013: 90 · 2012: 84
- FWCI
- 37.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA068377)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- IDH1 mutation, isocitrate dehydrogenase, glioma, HIF-1α, alpha-ketoglutarate, heterodimer formation, tumor suppressor, hypoxia, carcinogenesis, brain tumors, enzyme activity
- MeSH terms
- Adolescent, Adult, Aged, Astrocytoma, Brain Neoplasms, Cell Line, Child, Female, Glioblastoma, Glioma, Humans, Isocitrate Dehydrogenase, Ketoglutaric Acids, Male, Middle Aged, Oligodendroglioma, Oxalates, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Mutant Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, Biocatalysis, Protein Multimerization
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