Guan, Kun-Liang

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology

Autophagy in Disease and TherapyPI3K/AKT/mTOR signaling in cancer

Cited by 7,227

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 5,894

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 3,996

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 3,914

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 3,092

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 3,083

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.-H., Ito, S., Yang, C., Wang, P., Xiao, M.-T., et al. (2011) · Cancer Cell

Glioma Diagnosis and TreatmentEpigenetics and DNA Methylation

Cited by 2,875

TEAD mediates YAP-dependent gene induction and growth control

Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 2,498

Hippo pathway in organ size control, tissue homeostasis, and cancer

Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell

Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics

Cited by 2,206

MTOR: a pharmacologic target for autophagy regulation

Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 2,126

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 1,911

Regulation of cellular metabolism by protein lysine acetylation

Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T., Yao, J., Zhou, L., Zeng, Y., Li, H., et al. (2010) · Science

Biochemical Acid Research StudiesCancer-related gene regulation

Cited by 1,910

Mechanisms of Hippo pathway regulation

Meng, Z., Moroishi, T., & Guan, K.-L. (2016) · Genes & Development

Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics

Cited by 1,667

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell

Hippo pathway signaling and YAP/TAZProtein Kinase Regulation and GTPase Signaling

Cited by 1,628

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP

Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development

Hippo pathway signaling and YAP/TAZSignaling Pathways in Disease

Cited by 1,418

The Hippo Pathway: Biology and Pathophysiology

Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry

Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics

Cited by 1,387

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. (2006) · Cell

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 1,377

Regulation of TORC1 by Rag GTPases in nutrient response

Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 1,349

The Hippo pathway: regulators and regulations.

Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development

Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics

Cited by 1,231

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology

Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics

Cited by 1,205

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H., Liu, L., Liu, Y., Yang, C., Xu, Y., et al. (2012) · Genes & Development

Epigenetics and DNA MethylationCancer, Hypoxia, and Metabolism

Cited by 1,188

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

Zhao, S., Lin, Y., Xu, W., Jiang, W., Zha, Z., Wang, P., Yu, W., Li, Z., Gong, L., Peng, Y., et al. (2009) · Science

Cancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatment

Cited by 1,119

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J., Li, H., Xie, L., Zhao, W., Yao, Y., et al. (2010) · Science

Bacterial Genetics and BiotechnologyMicrobial metabolism and enzyme function

Cited by 1,008

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C., & Guan, K.-L. (2013) · Nature Reviews Molecular Cell Biology

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 894