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MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility
Open accessAbstract
Regulating Oocyte Maturation: Understanding exactly how ovarian follicles mature to generate fertile eggs is key to many aspects of fertility treatment. When the pituitary surge of luteinizing hormone (LH) binds to its receptor on granulosa cells of preovulatory follicles, a cascade of signaling events triggers granulosa cells to become luteal cells and the oocyte to resume meiosis. Fan et al. (p. 938 ; see the Perspective by Duggavathi and Murphy ), using the mouse as a model system, targeted disruption of the kinases ERK1 and ERK2 selectively in granulosa cells. The kinases were essential in vivo mediators of LH induction of ovulation and luteinization.
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Albuz, F. K., Sasseville, M., Lane, M., Armstrong, D. T., Thompson, J. G., & Gilchrist, R. B. (2010) · Human Reproduction · doi:10.1093/humrep/deq246 · Cited by 284
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Metadata
- Authors
- Fan, H.-Y., Liu, Z., Shimada, M., Sterneck, E., Johnson, P. F., Hedrick, S. M., & Richards, J. S.
- Venue
- Science
- Published
- 2009-05-15
- Volume
- 324
- Issue
- 5929
- Pages
- 938-941
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041655797
- Cited by
- 677
- References
- 0
- FWCI
- 38.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Fan, H.-Y., Liu, Z., Shimada, M., Sterneck, E., Johnson, P. F., Hedrick, S. M., & Richards, J. S. (2009). MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility. Science. https://doi.org/10.1126/science.1171396
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
