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Conserved Role of nanos Proteins in Germ Cell Development
Abstract
In Drosophila , maternally supplied Nanos functions in the migration of primordial germ cells (PGCs) into the gonad; in mice, zygotic genes are involved instead. We report the cloning and the functional analyses of nanos2 and nanos3 in mice. These genes are differentially expressed in mouse PGCs. nanos2 is predominantly expressed in male germ cells, and the elimination of this gene results in a complete loss of spermatogonia. However, nanos3 is found in migrating PGCs, and the elimination of this factor results in the complete loss of germ cells in both sexes. Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates.
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Cited by
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Wildwater, M., Campilho, A., Perez-Perez, J. M., Heidstra, R., Blilou, I., Korthout, H., Chatterjee, J., Mariconti, L., Gruissem, W., & Scheres, B. (2005) · Cell · doi:10.1016/j.cell.2005.09.042 · Cited by 395
Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430
Mishima, Y., Giraldez, A. J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A. F., & Inoue, K. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.086 · Cited by 321
The RNA-Binding Protein NANOS2 Is Required to Maintain Murine Spermatogonial Stem Cells
Sada, A., Suzuki, A., Suzuki, H., & Saga, Y. (2009) · Science · doi:10.1126/science.1172645 · Cited by 305
Self-citationRetinoic Acid Signalling and the Control of Meiotic Entry in the Human Fetal Gonad
Childs, A. J., Cowan, G., Kinnell, H. L., Anderson, R. A., & Saunders, P. T. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020249 · Cited by 157
Extavour, C. G., Pang, K., Matus, D. Q., & Martindale, M. Q. (2005) · Evolution & Development · doi:10.1111/j.1525-142x.2005.05023.x · Cited by 144
Metadata
- Authors
- Tsuda, M., Sasaoka, Y., Kiso, M., Abe, K., Haraguchi, S., Kobayashi, S., & Saga, Y.
- Venue
- Science
- Published
- 2003-08-29
- Volume
- 301
- Issue
- 5637
- Pages
- 1239-1241
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073918293
- Cited by
- 577
- References
- 0
- FWCI
- 19.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tsuda, M., Sasaoka, Y., Kiso, M., Abe, K., Haraguchi, S., Kobayashi, S., & Saga, Y. (2003). Conserved Role of nanos Proteins in Germ Cell Development. Science. https://doi.org/10.1126/science.1085222
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