The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Genome-Wide RNAi Screen Identifies Genes Involved in Intestinal Pathogenic Bacterial Infection
Open accessAbstract
Innate Immunity in the Fly Gut: Drosophila melanogaster is an important model system to study innate immunity, being both easy to manipulate and lacking an adaptive immune system. In order to identify genes that regulate innate immunity, Cronin et al. (p. 340 ; published online 11 June) performed an RNA interference screen on flies infected with the oral bacterial pathogen, Serratia marcescens . Genes involved in intestinal immunity and regulation of hemocytes, macrophage-like cells critical for phagocytosis and killing of the bacteria, were identified. Several hundred genes conferred either enhanced susceptibility or resistance to bacterial infection. Furthermore, the JAK/STAT signaling pathway was activated in intestinal stem cells after bacterial infection, resulting in enhanced susceptibility to infection, most likely through regulation of intestinal stem cell homeostasis.
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Cites
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,808
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Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,539
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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B.-G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,014
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
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Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
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The Role of Hemocytes in Anopheles gambiae Antiplasmodial Immunity
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Cited by
EGF signaling regulates the proliferation of intestinal stem cells in Drosophila
Biteau, B., & Jasper, H. (2011) · Development · doi:10.1242/dev.056671 · Cited by 306
Drosophila melanogaster as a model for human intestinal infection and pathology
Apidianakis, Y., & Rahme, L. G. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.003970 · Cited by 292
RNA Interference (RNAi) Screening in Drosophila
Heigwer, F., Port, F., & Boutros, M. (2018) · Genetics · doi:10.1534/genetics.117.300077 · Cited by 125
Metadata
- Authors
- Cronin, S. J. F., Nehme, N. T., Limmer, S., Liegeois, S., Pospisilik, J. A., Schramek, D., Leibbrandt, A., Simoes, R. D. M., Gruber, S., Puc, U., Ebersberger, I., Zoranovic, T., Neely, G. G., von Haeseler, A., Ferrandon, D., & Penninger, J. M.
- Venue
- Science
- Published
- 2009-07-17
- Volume
- 325
- Issue
- 5938
- Pages
- 340-343
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986364178
- Cited by
- 306
- References
- 36
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Cronin, S. J. F., Nehme, N. T., Limmer, S., Liegeois, S., Pospisilik, J. A., Schramek, D., Leibbrandt, A., Simoes, R. D. M., Gruber, S., Puc, U., Ebersberger, I., Zoranovic, T., Neely, G. G., von Haeseler, A., Ferrandon, D., & Penninger, J. M. (2009). Genome-Wide RNAi Screen Identifies Genes Involved in Intestinal Pathogenic Bacterial Infection. Science. https://doi.org/10.1126/science.1173164
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
