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Cited by 342Human-Animal Interaction StudiesGenetic and phenotypic traits in livestockChromosomal and Genetic Variations

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs

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Parker, Heidi G., VonHoldt, Bridgett M., Quignon, Pascale, Margulies, Elliott H., Shao, Stephanie, Mosher, Dana S., Spady, Tyrone C., Elkahloun, Abdel, Cargill, Michele, Jones, Paul G., Maslen, Cheryl L., Acland, Gregory M., Sutter, Nathan B., Kuroki, Keiichi, Bustamante, Carlos D., Wayne, Robert K., Ostrander, Elaine A.·2009·Science
DOI 10.1126/science.1173275PMC PMC2748762
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Abstract

Going Retro: In a year celebrating Darwin, the question of how new functional genes arise during evolution is of particular interest. Through a multibreed genetic analysis of the domestic dog, Parker et al. (p. 995 , published online 16 July; see the Perspective by Kaessmann ) find that the short-legged phenotype that characterizes at least 19 common dog breeds, including the corgi, dachshund, and basset hound, is specifically associated with the expression in developing bone of a gene encoding fibroblast growth factor 4 ( fgf4 ), a member of a gene family previously implicated in dwarfism in humans. Interestingly, the culprit fgf4 gene in dogs has the hallmarks of a “retrogene,” a gene that arises when a parental gene is duplicated through an RNA-based copying mechanism.

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Metadata

Authors
Parker, H. G., VonHoldt, B. M., Quignon, P., Margulies, E. H., Shao, S., Mosher, D. S., Spady, T. C., Elkahloun, A., Cargill, M., Jones, P. G., Maslen, C. L., Acland, G. M., Sutter, N. B., Kuroki, K., Bustamante, C. D., Wayne, R. K., & Ostrander, E. A.
Affiliations
  • National Institutes of Health (US)
  • University of California, Los Angeles (US)
  • Affymetrix (United States) (US)
  • Waltham Centre for Pet Nutrition (GB)
  • Oregon Health & Science University (US)
  • Cornell University (US)
  • University of Missouri (US)
Corresponding author
  • Cargill, Michele
  • Ostrander, Elaine A.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2009-08-21
Volume
325
Issue
5943
Pages
995-998
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1173275
PMC
PMC2748762
OpenAlex
W1981244256
Cited by
342
References
36
Citations by year
2026: 10 · 2025: 12 · 2024: 28 · 2023: 17 · 2022: 18 · 2021: 20 · 2020: 22 · 2019: 20 · 2018: 19 · 2017: 13 · 2016: 25 · 2015: 15 · 2014: 14 · 2013: 22 · 2012: 28
FWCI
16.87
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (Z99 HG999999)
  • National Human Genome Research Institute (T32HG002536)
  • National Eye Institute (R01EY006855)
  • National Institute of General Medical Sciences (R01GM083606, 1R01GM83606, R24GM082910)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords
FGF4, retrogenes, retrotransposition, chondrodysplasia, gene expression, phenotypic diversity, dog evolution
MeSH terms
Animals, Breeding, Dogs, Extremities, Gene Expression Regulation, Gene Frequency, Haplotypes, Humerus, Pedigree, Phenotype, Regulatory Sequences, Nucleic Acid, Selection, Genetic, Retroelements, Evolution, Molecular, Chondrocytes, Long Interspersed Nucleotide Elements, Genes, Duplicate, Oligonucleotide Array Sequence Analysis, Gene Duplication, Polymorphism, Single Nucleotide, Fibroblast Growth Factor 4, Genome-Wide Association Study

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