Properties of statistical tests of neutrality for DNA polymorphism data
Abstract
A class of statistical tests based on molecular polymorphism data is studied to determine size and power properties. The class includes Tajima's D statistic as well as the D* and F* tests proposed by Fu and Li. A new method of constructing critical values for these tests is described. Simulations indicate that Tajima's test is generally most powerful against the alternative hypotheses of selective sweep, population bottleneck, and population subdivision, among tests within this class. However, even Tajima's test can detect a selective sweep or bottleneck only if it has occurred within a specific interval of time in the recent past or population subdivision only when it has persisted for a very long time. For greatest power against the particular alternatives studied here, it is better to sequence more alleles than more sites.
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The SFS of polymorphisms in genomic regions containing hybrid incompatibilities is expected to depart from the genome-wide SFS.
“Therefore, we might expect the site frequency spectrum (SFS) of polymorphisms in genomic regions containing hybrid incompatibilities to depart from the genome-wide SFS (Braverman et al. 1995; Simonsen et al. 1995).”
From Finding Hybrid Incompatibilities Using Genome Sequences from Hybrid Populations (2021) · cites this paper as Simonsen et al. 1995
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- Authors
- Simonsen, K. L., Churchill, G. A., & Aquadro, C. F.
- Affiliations
- Cornell University (US)
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-09-01
- Volume
- 141
- Issue
- 1
- Pages
- 413-429
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2113420705
- Cited by
- 681
- References
- 23
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 10 · 2023: 12 · 2022: 15 · 2021: 19 · 2020: 17 · 2019: 13 · 2018: 15 · 2017: 14 · 2016: 19 · 2015: 21 · 2014: 42 · 2013: 21 · 2012: 21
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9113307)
- U.S. Department of Energy
- National Institute of General Medical Sciences (R01GM036431, GM-3643)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- neutrality tests, DNA polymorphism, selective sweeps, population bottleneck, population subdivision, statistical power, critical values, molecular evolution
- MeSH terms
- Computer Simulation, DNA, Models, Genetic, Polymorphism, Genetic, Models, Statistical
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