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Cell Growth and Size Homeostasis in Proliferating Animal Cells
Open accessAbstract
Size Matters: Cells of different types come in different sizes. Size is established by a trade-off of growth and division; as a result, the distribution of cell size in a population is held stable over time. A classic question in cell physiology is whether the growth rate of cells is constant over time or whether, as cells grow bigger during the cell cycle, they grow faster and faster. Using experimental and mathematical approaches, Tzur et al. (p. 167 ; see the Perspective by Edgar and Kim ) show that the growth rate of mouse lymphoblastoid cells in culture is slow in the G 1 phase and then increases to reach a constant exponential rate. Thus, there is an active size-control mechanism that limits size variation in animal cells.
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Cited by
Robust Growth of Escherichia coli
Wang, P., Robert, L., Pelletier, J., Dang, W. L., Taddei, F., Wright, A., & Jun, S. (2010) · Current Biology · doi:10.1016/j.cub.2010.04.045 · Cited by 1,014
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Perelman, A., Wachtel, C., Cohen, M., Haupt, S., Shapiro, H., & Tzur, A. (2012) · Cell Death & Disease · doi:10.1038/cddis.2012.171 · Cited by 699
Self-citationUsing buoyant mass to measure the growth of single cells
Godin, M., Delgado, F. F., Son, S., Grover, W. H., Bryan, A. K., Tzur, A., Jorgensen, P., Payer, K., Grossman, A. D., Kirschner, M. W., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1452 · Cited by 394
Self-citationBiosensor reveals multiple sources for mitochondrial NAD +
Cambronne, X. A., Stewart, M. L., Kim, D., Jones-Brunette, A. M., Morgan, R. K., Farrens, D. L., Cohen, M. S., & Goodman, R. H. (2016) · Science · doi:10.1126/science.aad5168 · Cited by 407
Lloyd, A. C. (2013) · Cell · doi:10.1016/j.cell.2013.08.053 · Cited by 393
Metadata
- Authors
- Tzur, A., Kafri, R., LeBleu, V. S., Lahav, G., & Kirschner, M. W.
- Venue
- Science
- Published
- 2009-07-10
- Volume
- 325
- Issue
- 5937
- Pages
- 167-171
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2162791825
- Cited by
- 402
- References
- 0
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Tzur, A., Kafri, R., LeBleu, V. S., Lahav, G., & Kirschner, M. W. (2009). Cell Growth and Size Homeostasis in Proliferating Animal Cells. Science. https://doi.org/10.1126/science.1174294
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
